Inflammatory status, body composition and ethnic differences in bone mineral density: The Southall and Brent revisited study.
Inflammatory status, body composition and ethnic differences in bone mineral density: The Southall and Brent revisited study.
Ethnic differences in bone mineral density (BMD) and fracture risk are well-described; the aim of this study was to investigate whether central adiposity or inflammatory status contribute to these ethnic differences in BMD in later life. The Southall and Brent Revisited study (SABRE) is a UK-based tri-ethnic cohort of men and women of European, South Asian or African Caribbean origin. At the most recent SABRE follow-up (2014-2018), in addition to measures of cardiometabolic phenotype, participants had dual-energy X-ray absorptiometry (DXA) bone and body composition scans. Multiple linear regression was used to determine whether markers of body composition, central adiposity or inflammatory status contributed to ethnic differences in BMD. In men and women, age- and height-adjusted BMD at all sites was higher in African Caribbeans compared to Europeans (femoral neck: standardised β (95% confidence interval): men: 1.00SD (0.75, 1.25); women: 0.77SD (0.56, 0.99)). South Asian men had higher BMD than European men at the hip (femoral neck: 0.34SD (95%CI: 0.15, 0.54)). Although adjustment for body mass index (BMI) or lean mass index (LMI) at the lumbar spine reduced the size of the difference in BMD between African Caribbean and European men (age and height adjusted difference: 0.35SD (0.08, 0.62); age and BMI adjusted difference: 0.25SD (-0.02, 0.51)), in both men and women ethnic differences remained after adjustment for measures of central adiposity (estimated visceral adipose tissue mass (VAT mass) and android to gynoid ratio) and inflammation (interleukin-6 (logIL-6) and C-reactive protein (logCRP)). Furthermore, in women, we observed ethnic differences in the relationship between BMI (overall interaction: p = 0.04), LMI (p = 0.04) or VAT mass (p = 0.009) and standardised lumbar spine BMD. In this tri-ethnic cohort, ethnic differences in BMD at the femoral neck, total hip or lumbar spine were not explained by BMI, central adiposity or inflammatory status. Given ethnic differences in fracture incidence, it is important to further investigate why ethnic differences in BMD exist.
Body composition, Bone mineral density, Epidemiology, Ethnicity, Inflammation, Osteoporosis
Durdin, Ruth, Lauren
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Parsons, Camille
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Dennison, Elaine
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Williams, Suzanne
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Tillin, Therese
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Chaturvedi, Nishi
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Cooper, Cyrus
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Harvey, Nicholas
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Ward, Kate
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7 December 2021
Durdin, Ruth, Lauren
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Parsons, Camille
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Dennison, Elaine
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Williams, Suzanne
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Tillin, Therese
e881c32a-69ee-43e8-83c1-9850a087fae5
Chaturvedi, Nishi
13e1781a-2d09-4331-ba39-c250734e056e
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Ward, Kate
39bd4db1-c948-4e32-930e-7bec8deb54c7
Durdin, Ruth, Lauren, Parsons, Camille, Dennison, Elaine, Williams, Suzanne, Tillin, Therese, Chaturvedi, Nishi, Cooper, Cyrus, Harvey, Nicholas and Ward, Kate
(2021)
Inflammatory status, body composition and ethnic differences in bone mineral density: The Southall and Brent revisited study.
Bone, 155, [116286].
(doi:10.1016/j.bone.2021.116286).
Abstract
Ethnic differences in bone mineral density (BMD) and fracture risk are well-described; the aim of this study was to investigate whether central adiposity or inflammatory status contribute to these ethnic differences in BMD in later life. The Southall and Brent Revisited study (SABRE) is a UK-based tri-ethnic cohort of men and women of European, South Asian or African Caribbean origin. At the most recent SABRE follow-up (2014-2018), in addition to measures of cardiometabolic phenotype, participants had dual-energy X-ray absorptiometry (DXA) bone and body composition scans. Multiple linear regression was used to determine whether markers of body composition, central adiposity or inflammatory status contributed to ethnic differences in BMD. In men and women, age- and height-adjusted BMD at all sites was higher in African Caribbeans compared to Europeans (femoral neck: standardised β (95% confidence interval): men: 1.00SD (0.75, 1.25); women: 0.77SD (0.56, 0.99)). South Asian men had higher BMD than European men at the hip (femoral neck: 0.34SD (95%CI: 0.15, 0.54)). Although adjustment for body mass index (BMI) or lean mass index (LMI) at the lumbar spine reduced the size of the difference in BMD between African Caribbean and European men (age and height adjusted difference: 0.35SD (0.08, 0.62); age and BMI adjusted difference: 0.25SD (-0.02, 0.51)), in both men and women ethnic differences remained after adjustment for measures of central adiposity (estimated visceral adipose tissue mass (VAT mass) and android to gynoid ratio) and inflammation (interleukin-6 (logIL-6) and C-reactive protein (logCRP)). Furthermore, in women, we observed ethnic differences in the relationship between BMI (overall interaction: p = 0.04), LMI (p = 0.04) or VAT mass (p = 0.009) and standardised lumbar spine BMD. In this tri-ethnic cohort, ethnic differences in BMD at the femoral neck, total hip or lumbar spine were not explained by BMI, central adiposity or inflammatory status. Given ethnic differences in fracture incidence, it is important to further investigate why ethnic differences in BMD exist.
Text
Manuscript_20211118
- Accepted Manuscript
More information
Accepted/In Press date: 2 December 2021
e-pub ahead of print date: 7 December 2021
Published date: 7 December 2021
Additional Information:
Funding Information:
The SABRE study was funded at baseline by the Medical Research Council, Diabetes UK, and British Heart Foundation. At follow-up, this research was funded in part by the Wellcome Trust [082464/Z/07/Z] and British Heart Foundation [SP/07/001/23603, PG/08/103, PG/12/29/29497 and CS/13/1/30327]. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Funding Information:
RD is supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre .
Funding Information:
NC receives support from the National Institute for Health Research University College London Hospitals Biomedical Research Centre.
Publisher Copyright:
© 2021
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
Keywords:
Body composition, Bone mineral density, Epidemiology, Ethnicity, Inflammation, Osteoporosis
Identifiers
Local EPrints ID: 453112
URI: http://eprints.soton.ac.uk/id/eprint/453112
ISSN: 8756-3282
PURE UUID: f393aa61-5e08-4d12-bfea-eafe0f11699e
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Date deposited: 08 Jan 2022 21:33
Last modified: 18 Mar 2024 05:05
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Contributors
Author:
Ruth, Lauren Durdin
Author:
Camille Parsons
Author:
Suzanne Williams
Author:
Therese Tillin
Author:
Nishi Chaturvedi
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