Understanding the Tuberculosis granuloma: the Matrix revolutions
Understanding the Tuberculosis granuloma: the Matrix revolutions
Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore, TB has killed many more humans than any other pathogen, after prolonged coevolution to optimise its pathogenic strategies. Full understanding of fundamental disease processes in humans is necessary to successfully combat this highly successful pathogen. While the importance of immunodeficiency has been long recognised, biologic therapies and unbiased approaches are providing unprecedented insights into the intricacy of the host–pathogen interaction. The nature of a protective response is more complex than previously hypothesised. Here, we integrate recent evidence from human studies and unbiased approaches to consider how Mtb causes human TB and highlight the recurring theme of extracellular matrix (ECM) turnover.
bioinformatic analysis, extracellular matrix, granuloma, metalloprotease, tuberculosis
143-154
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Polak, Marta
e0ac5e1a-7074-4776-ba23-490bd4da612d
Reichmann, MT
d887f227-13a8-4384-a1c5-d3c229cd0642
Leslie, Alasdair
84d4f578-f3c0-46cc-9c83-a8d9bb40c38c
15 December 2021
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Polak, Marta
e0ac5e1a-7074-4776-ba23-490bd4da612d
Reichmann, MT
d887f227-13a8-4384-a1c5-d3c229cd0642
Leslie, Alasdair
84d4f578-f3c0-46cc-9c83-a8d9bb40c38c
Elkington, Paul, Polak, Marta, Reichmann, MT and Leslie, Alasdair
(2021)
Understanding the Tuberculosis granuloma: the Matrix revolutions.
Trends in Molecular Medicine, 28 (2), .
(doi:10.1016/j.molmed.2021.11.004).
Abstract
Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains the top global infectious pandemic after coronavirus disease 2019 (COVID-19). Furthermore, TB has killed many more humans than any other pathogen, after prolonged coevolution to optimise its pathogenic strategies. Full understanding of fundamental disease processes in humans is necessary to successfully combat this highly successful pathogen. While the importance of immunodeficiency has been long recognised, biologic therapies and unbiased approaches are providing unprecedented insights into the intricacy of the host–pathogen interaction. The nature of a protective response is more complex than previously hypothesised. Here, we integrate recent evidence from human studies and unbiased approaches to consider how Mtb causes human TB and highlight the recurring theme of extracellular matrix (ECM) turnover.
Text
Matrix_revolutions_RS_accepted
- Accepted Manuscript
More information
e-pub ahead of print date: 15 December 2021
Published date: 15 December 2021
Additional Information:
Funding Information:
P.E. was supported by MRC Global Challenges Research Fund MR/P023754/1 ; M.E.P. was supported by Wellcome Trust Sir Henry Dale Fellowship , 109377/Z/15/Z ; M.T.R. was supported by Rosetrees Trust ( M540 ); and A.L. was supported by Wellcome Trust ( 210662/Z/18/Z ).
Publisher Copyright:
© 2021 Elsevier Ltd
Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.
Keywords:
bioinformatic analysis, extracellular matrix, granuloma, metalloprotease, tuberculosis
Identifiers
Local EPrints ID: 453132
URI: http://eprints.soton.ac.uk/id/eprint/453132
ISSN: 1471-4914
PURE UUID: b5d657ee-e440-4f85-88c8-0bde61d312f2
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Date deposited: 08 Jan 2022 22:32
Last modified: 30 Nov 2024 05:07
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Author:
MT Reichmann
Author:
Alasdair Leslie
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