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Adult attention-deficit/hyperactivity disorder among alcohol use disorder inpatients is associated with food addiction and binge eating, but not BMI

Adult attention-deficit/hyperactivity disorder among alcohol use disorder inpatients is associated with food addiction and binge eating, but not BMI
Adult attention-deficit/hyperactivity disorder among alcohol use disorder inpatients is associated with food addiction and binge eating, but not BMI

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is associated with binge eating (BE), food addiction (FA), and obesity/higher BMI in individuals without alcohol use disorder (AUD). ADHD is highly prevalent in patients with AUD, but it is unknown whether the presence of comorbid AUD might change the nature of the association between ADHD, BE, FA and BMI (food and alcohol may either compete for the same brain neurocircuitry or share vulnerability risk factors). Here, we filled this gap by testing the association between ADHD and FA/BE in adult patients hospitalized for AUD, with the strength of simultaneously assessing childhood and adult ADHD. We also investigated the association between ADHD and BMI, and the other factors associated with BMI (FA/BE, AUD severity). Methods: We included 149 AUD inpatients between November 2018 and April 2019. We assessed both childhood and adulthood ADHD (Wender Utah Render Scale and Adult ADHD Self-Report Scale), FA (modified Yale Food Addiction Scale 2.0), BE (Binge Eating Scale), and BMI and AUD (clinical assessment). Results: In multivariable analyses adjusted for age, adult ADHD was associated with higher BE scores (p = .048), but not significant BE (9% vs. 7%; p = .70). ADHD was also associated with FA diagnosis and the number or FA symptoms, with larger effect size for adult (ORs: 9.45[95%CI: 2.82–31.74] and 1.38[1.13–1.69], respectively) than childhood ADHD (ORs: 4.45[1.37–14.46] and 1.40[1.13–1.75], respectively). In multivariable analysis, BMI was associated with both significant BE (p < .001) and FA diagnosis (p = .014), but not adult ADHD nor AUD severity. Conclusion: In patients hospitalized for AUD, self-reported adult ADHD was associated with FA and BE, but not BMI. Our results set the groundwork for longitudinal research on the link between ADHD, FA, BE, and BMI in AUD inpatients.

Addictive, Addictive-like eating, Alcohol use disorder, Attention-deficit disorder/hyperactivity, Behavior, Eating addiction, Eating disorders, Food addiction, Substance-related and addictive disorders
0195-6663
El Ayoubi, Hussein
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Barrault, Servane
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Gateau, Adrien
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Cortese, Samuele
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Frammery, Julie
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Mollat, Elodie
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Bonnet-brilhault, Fréderique
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Grall-bronnec, Marie
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Ballon, Nicolas
60bba3eb-819f-430a-bcf1-03129b187238
Brunault, Paul
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El Ayoubi, Hussein
e968f3bb-a000-45ad-9e13-2479649ee120
Barrault, Servane
b1f79b0a-4f9e-486a-a216-6b30d107c3be
Gateau, Adrien
0ee97981-08de-4c52-92ae-fb50d9fead1a
Cortese, Samuele
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Frammery, Julie
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Mollat, Elodie
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Bonnet-brilhault, Fréderique
cc5f87c9-e9b3-44d6-8f1f-2ccc1af2c05c
Grall-bronnec, Marie
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Ballon, Nicolas
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Brunault, Paul
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El Ayoubi, Hussein, Barrault, Servane, Gateau, Adrien, Cortese, Samuele, Frammery, Julie, Mollat, Elodie, Bonnet-brilhault, Fréderique, Grall-bronnec, Marie, Ballon, Nicolas and Brunault, Paul (2022) Adult attention-deficit/hyperactivity disorder among alcohol use disorder inpatients is associated with food addiction and binge eating, but not BMI. Appetite, 168, [105665]. (doi:10.1016/j.appet.2021.105665).

Record type: Article

Abstract

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is associated with binge eating (BE), food addiction (FA), and obesity/higher BMI in individuals without alcohol use disorder (AUD). ADHD is highly prevalent in patients with AUD, but it is unknown whether the presence of comorbid AUD might change the nature of the association between ADHD, BE, FA and BMI (food and alcohol may either compete for the same brain neurocircuitry or share vulnerability risk factors). Here, we filled this gap by testing the association between ADHD and FA/BE in adult patients hospitalized for AUD, with the strength of simultaneously assessing childhood and adult ADHD. We also investigated the association between ADHD and BMI, and the other factors associated with BMI (FA/BE, AUD severity). Methods: We included 149 AUD inpatients between November 2018 and April 2019. We assessed both childhood and adulthood ADHD (Wender Utah Render Scale and Adult ADHD Self-Report Scale), FA (modified Yale Food Addiction Scale 2.0), BE (Binge Eating Scale), and BMI and AUD (clinical assessment). Results: In multivariable analyses adjusted for age, adult ADHD was associated with higher BE scores (p = .048), but not significant BE (9% vs. 7%; p = .70). ADHD was also associated with FA diagnosis and the number or FA symptoms, with larger effect size for adult (ORs: 9.45[95%CI: 2.82–31.74] and 1.38[1.13–1.69], respectively) than childhood ADHD (ORs: 4.45[1.37–14.46] and 1.40[1.13–1.75], respectively). In multivariable analysis, BMI was associated with both significant BE (p < .001) and FA diagnosis (p = .014), but not adult ADHD nor AUD severity. Conclusion: In patients hospitalized for AUD, self-reported adult ADHD was associated with FA and BE, but not BMI. Our results set the groundwork for longitudinal research on the link between ADHD, FA, BE, and BMI in AUD inpatients.

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More information

Accepted/In Press date: 24 August 2021
e-pub ahead of print date: 26 August 2021
Published date: January 2022
Additional Information: Funding Information: We thank the patients who participated to this study. We thank Zakaria El Ayoubi and Sourya Assaf for revising the English version of the manuscript.
Keywords: Addictive, Addictive-like eating, Alcohol use disorder, Attention-deficit disorder/hyperactivity, Behavior, Eating addiction, Eating disorders, Food addiction, Substance-related and addictive disorders

Identifiers

Local EPrints ID: 453154
URI: http://eprints.soton.ac.uk/id/eprint/453154
ISSN: 0195-6663
PURE UUID: 213b90fb-177b-405d-89e0-3b80f303fae8
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 10 Jan 2022 17:47
Last modified: 23 Jul 2022 02:10

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Contributors

Author: Hussein El Ayoubi
Author: Servane Barrault
Author: Adrien Gateau
Author: Samuele Cortese ORCID iD
Author: Julie Frammery
Author: Elodie Mollat
Author: Fréderique Bonnet-brilhault
Author: Marie Grall-bronnec
Author: Nicolas Ballon
Author: Paul Brunault

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