Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences
The societal burden of non-communicable disease is closely linked with environmental exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the earliest preimplantation period of the life course onwards. Epigenetic variations caused by a compromised maternal nutritional status can affect embryonic development. This review summarises the main epigenetic modifications in mammals, especially DNA methylation, histone modifications, and ncRNA. These epigenetic changes can compromise the health of the offspring later in life. We discuss different types of nutritional stressors in human and animal models, such as maternal undernutrition, seasonal diets, low-protein diet, high-fat diet, and synthetic folic acid supplement use, and how these nutritional exposures epigenetically affect target genes and their outcomes. In addition, we review the concept of thrifty genes during the preimplantation period, and some examples that relate to epigenetic change and diet. Finally, we discuss different examples of maternal diets, their effect on outcomes, and their relationship with assisted reproductive technology (ART), including their implications on epigenetic modifications.
ART, DOHaD, Embryo, Epigenetics, Maternal diet, Preimplantation period
Peral Sanchez, Irene
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Hojeij, Batoul
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Ojeda Pedraza, Diego
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Steegers-Theunissen, Regine P.M.
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Willaime-Morawek, Sandrine
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23 December 2021
Peral Sanchez, Irene
2c21bdc6-ce7b-47c0-be98-05e937e86c88
Hojeij, Batoul
ac9053f4-6147-443c-9e2c-1649315db8f2
Ojeda Pedraza, Diego
967ac799-26ba-4589-b507-4a88a1ca1859
Steegers-Theunissen, Regine P.M.
c0c708b4-f765-4330-825a-b8c3a4d4edd4
Willaime-Morawek, Sandrine
24a2981f-aa9e-4bf6-ad12-2ccf6b49f1c0
Peral Sanchez, Irene, Hojeij, Batoul, Ojeda Pedraza, Diego, Steegers-Theunissen, Regine P.M. and Willaime-Morawek, Sandrine
(2021)
Epigenetics in the Uterine Environment: How Maternal Diet and ART May Influence the Epigenome in the Offspring with Long-Term Health Consequences.
Genes, 13 (1), [31].
(doi:10.3390/genes13010031).
Abstract
The societal burden of non-communicable disease is closely linked with environmental exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the earliest preimplantation period of the life course onwards. Epigenetic variations caused by a compromised maternal nutritional status can affect embryonic development. This review summarises the main epigenetic modifications in mammals, especially DNA methylation, histone modifications, and ncRNA. These epigenetic changes can compromise the health of the offspring later in life. We discuss different types of nutritional stressors in human and animal models, such as maternal undernutrition, seasonal diets, low-protein diet, high-fat diet, and synthetic folic acid supplement use, and how these nutritional exposures epigenetically affect target genes and their outcomes. In addition, we review the concept of thrifty genes during the preimplantation period, and some examples that relate to epigenetic change and diet. Finally, we discuss different examples of maternal diets, their effect on outcomes, and their relationship with assisted reproductive technology (ART), including their implications on epigenetic modifications.
Text
genes-13-00031
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More information
Published date: 23 December 2021
Additional Information:
Funding Information:
This review has received funding from the European Union?s Horizon 2020 research and innovation program under the Marie Sk?odowska-Curie grant agreement No. 812660 (DohARTNET) and under Colciencias doctoral scholarship (convocatoria 646-Doctorados en el exterior) and Newton-Caldas Fund scholarship (convenio 334 of 2015).
Keywords:
ART, DOHaD, Embryo, Epigenetics, Maternal diet, Preimplantation period
Identifiers
Local EPrints ID: 453170
URI: http://eprints.soton.ac.uk/id/eprint/453170
ISSN: 2073-4425
PURE UUID: 3c01bb93-bddf-4c10-8226-d801c80f0be2
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Date deposited: 10 Jan 2022 17:56
Last modified: 17 Mar 2024 03:13
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Contributors
Author:
Irene Peral Sanchez
Author:
Batoul Hojeij
Author:
Diego Ojeda Pedraza
Author:
Regine P.M. Steegers-Theunissen
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