Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly
Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly
The self-assembly of inorganic nanoparticles to larger structures is of great research interest as it allows the fabrication of novel materials with collective properties correlated to the nanoparticles' individual characteristics. Recently developed methods for controlling nanoparticle organisation have enabled the fabrication of a range of new materials. Amongst these, the assembly of nanoparticles using DNA has attracted significant attention due to the highly selective recognition between complementary DNA strands, DNA nanostructure versatility, and ease of DNA chemical modification. In this review we discuss the application of various chemical DNA modifications and molecular intercalators as tools for the manipulation of DNA-nanoparticle structures. In detail, we discuss how DNA modifications and small molecule intercalators have been employed in the chemical and photochemical DNA ligation in nanostructures; DNA rotaxanes and catenanes associated with reconfigurable nanoparticle assemblies; and DNA backbone modifications including locked nucleic acids, peptide nucleic acids and borane nucleic acids, which affect the stability of nanostructures in complex environments. We conclude by highlighting the importance of maximising the synergy between the communities of DNA chemistry and nanoparticle self-assembly with the aim to enrich the library of tools available for the manipulation of nanostructures.
13410-13440
De Fazio, Angela F
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Misatziou, Doxi
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Baker, Ysobel R
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Muskens, Otto L
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Brown, Tom
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Kanaras, Antonios G
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18 November 2021
De Fazio, Angela F
e4115c3b-5447-4f30-8608-9e4115bc7d59
Misatziou, Doxi
455cd8ac-4bb1-485d-b6dd-c8609882017c
Baker, Ysobel R
4fceec1f-89ed-4a32-a753-8967daf6763a
Muskens, Otto L
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Kanaras, Antonios G
667ecfdc-7647-4bd8-be03-a47bf32504c7
De Fazio, Angela F, Misatziou, Doxi, Baker, Ysobel R, Muskens, Otto L, Brown, Tom and Kanaras, Antonios G
(2021)
Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly.
Chemical Society Reviews, 50 (23), .
(doi:10.1039/d1cs00632k).
Abstract
The self-assembly of inorganic nanoparticles to larger structures is of great research interest as it allows the fabrication of novel materials with collective properties correlated to the nanoparticles' individual characteristics. Recently developed methods for controlling nanoparticle organisation have enabled the fabrication of a range of new materials. Amongst these, the assembly of nanoparticles using DNA has attracted significant attention due to the highly selective recognition between complementary DNA strands, DNA nanostructure versatility, and ease of DNA chemical modification. In this review we discuss the application of various chemical DNA modifications and molecular intercalators as tools for the manipulation of DNA-nanoparticle structures. In detail, we discuss how DNA modifications and small molecule intercalators have been employed in the chemical and photochemical DNA ligation in nanostructures; DNA rotaxanes and catenanes associated with reconfigurable nanoparticle assemblies; and DNA backbone modifications including locked nucleic acids, peptide nucleic acids and borane nucleic acids, which affect the stability of nanostructures in complex environments. We conclude by highlighting the importance of maximising the synergy between the communities of DNA chemistry and nanoparticle self-assembly with the aim to enrich the library of tools available for the manipulation of nanostructures.
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d1cs00632k
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Accepted/In Press date: 10 November 2021
Published date: 18 November 2021
Additional Information:
Funding Information:
AGK and ADF acknowledge funding from the Biotechnology and Biological Sciences Research Council (BBSRC) (BB/ P017711/1). TB and YB also acknowledge funding from BBSRC (BB/S018794/1). OM, DM and AGK would like to thank support from the Leverhulme Trust (RPG-2018-251).
Publisher Copyright:
© The Royal Society of Chemistry.
Identifiers
Local EPrints ID: 453208
URI: http://eprints.soton.ac.uk/id/eprint/453208
ISSN: 0306-0012
PURE UUID: 57932f79-a819-4df3-9017-cca84a029a2d
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Date deposited: 11 Jan 2022 17:31
Last modified: 17 Mar 2024 04:17
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Author:
Angela F De Fazio
Author:
Ysobel R Baker
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