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Anti-inflammatory mechanisms of leukotriene modulators

Anti-inflammatory mechanisms of leukotriene modulators
Anti-inflammatory mechanisms of leukotriene modulators

Models to explain the cytokine and chemokine mechanisms of airway eosinophilia in asthma must now take into account the definitive evidence from clinical trials of specific leukotriene modulators that cysteinyl-LTs make a substantial, perhaps even the predominant, contribution to eosinophil migration in vivo. Indeed, until the advent of clinical trials of relevant cytokine antagonists, the leukotriene modulators may remain the only family of drugs with a known and specific mechanism of action that are capable of suppressing airway and blood eosinophilia. Recent evidence that at least part of the eosinophilic activity of cys-LTs may depend on secondary release of eosinophilopoietic cytokines such as IL-5 by T lymphocytes and other cells [9,38] should promote further study of the effects of cys-LTs on cytokine expression in leucocytes and airway cells.

0954-7894
1449-1453
Diamant, Z.
aa9b17e3-0a77-428b-a2a1-2fc7ee5405dc
Sampson, A. P.
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60
Diamant, Z.
aa9b17e3-0a77-428b-a2a1-2fc7ee5405dc
Sampson, A. P.
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60

Diamant, Z. and Sampson, A. P. (2001) Anti-inflammatory mechanisms of leukotriene modulators. Clinical and Experimental Allergy, 29 (11), 1449-1453. (doi:10.1046/j.1365-2222.1999.00711.x).

Record type: Review

Abstract

Models to explain the cytokine and chemokine mechanisms of airway eosinophilia in asthma must now take into account the definitive evidence from clinical trials of specific leukotriene modulators that cysteinyl-LTs make a substantial, perhaps even the predominant, contribution to eosinophil migration in vivo. Indeed, until the advent of clinical trials of relevant cytokine antagonists, the leukotriene modulators may remain the only family of drugs with a known and specific mechanism of action that are capable of suppressing airway and blood eosinophilia. Recent evidence that at least part of the eosinophilic activity of cys-LTs may depend on secondary release of eosinophilopoietic cytokines such as IL-5 by T lymphocytes and other cells [9,38] should promote further study of the effects of cys-LTs on cytokine expression in leucocytes and airway cells.

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Clin Experimental Allergy - 2001 - Diamant - Anti‐inflammatory mechanisms of leukotriene modulators - Version of Record
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Published date: 24 December 2001
Additional Information: Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

Identifiers

Local EPrints ID: 453324
URI: http://eprints.soton.ac.uk/id/eprint/453324
ISSN: 0954-7894
PURE UUID: b921c389-3d6d-4c40-abc5-19ae99ff6d9d

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Date deposited: 12 Jan 2022 17:48
Last modified: 29 Jun 2022 16:46

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Contributors

Author: Z. Diamant
Author: A. P. Sampson

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