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Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy

Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy
Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy
Nanoparticle-based magnetic hyperthermia is a well-known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic-shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs’ feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.
1521-4095
Balakrishnan, Preethi Bala
c80abc04-4ac5-4d57-b66d-0050cd41c847
Silvestri, Niccolò
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Fernandez-Cabada, Tamara
702497a6-9cee-4fe8-9ad5-8b694763acbc
Marinaro, Federica
d55dc46d-cc18-4053-a285-c04cdcb0f474
Fernandes, Soraia
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Fiorito, Sergio
ef74a225-0c68-4c77-b8e9-29b5914fefe6
Miscuglio, Mario
fd8c2547-c62b-4a68-918b-8d664ee55e06
Serantes, David
3a38ec38-1098-4b01-a139-45ee0f950d22
Ruta, Sergiu
9e68bb4a-ee48-4ec6-a25b-e9a5bb4dd91e
Livesey, Karen
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Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Chantrell, Roy
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Pellegrino, Teresa
43b700d8-af3a-48c2-a800-5d3c8d940a00
Balakrishnan, Preethi Bala
c80abc04-4ac5-4d57-b66d-0050cd41c847
Silvestri, Niccolò
77397e42-e47a-4a93-9319-08a3cee1bd05
Fernandez-Cabada, Tamara
702497a6-9cee-4fe8-9ad5-8b694763acbc
Marinaro, Federica
d55dc46d-cc18-4053-a285-c04cdcb0f474
Fernandes, Soraia
d0b80f0d-876f-464e-82e4-bbfc59d6e13e
Fiorito, Sergio
ef74a225-0c68-4c77-b8e9-29b5914fefe6
Miscuglio, Mario
fd8c2547-c62b-4a68-918b-8d664ee55e06
Serantes, David
3a38ec38-1098-4b01-a139-45ee0f950d22
Ruta, Sergiu
9e68bb4a-ee48-4ec6-a25b-e9a5bb4dd91e
Livesey, Karen
a2142723-e906-499f-a7ad-fc78d8d9f923
Hovorka, Ondrej
a12bd550-ad45-4963-aa26-dd81dd1609ee
Chantrell, Roy
1e245730-a8d3-4127-9269-24e8dd4fbc02
Pellegrino, Teresa
43b700d8-af3a-48c2-a800-5d3c8d940a00

Balakrishnan, Preethi Bala, Silvestri, Niccolò, Fernandez-Cabada, Tamara, Marinaro, Federica, Fernandes, Soraia, Fiorito, Sergio, Miscuglio, Mario, Serantes, David, Ruta, Sergiu, Livesey, Karen, Hovorka, Ondrej, Chantrell, Roy and Pellegrino, Teresa (2020) Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy. Advanced Materials, 32 (45). (doi:10.1002/adma.202003712).

Record type: Article

Abstract

Nanoparticle-based magnetic hyperthermia is a well-known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic-shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs’ feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy.

Text
Advanced Materials - 2020 - Balakrishnan - Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles Mild Hyperthermia - Version of Record
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Accepted/In Press date: 28 July 2020
e-pub ahead of print date: 1 October 2020
Published date: 1 October 2020

Identifiers

Local EPrints ID: 453350
URI: http://eprints.soton.ac.uk/id/eprint/453350
ISSN: 1521-4095
PURE UUID: 2f7290c1-e4bc-4f8e-95b5-1a824ab775b7
ORCID for Ondrej Hovorka: ORCID iD orcid.org/0000-0002-6707-4325

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Date deposited: 13 Jan 2022 17:55
Last modified: 28 Apr 2022 02:09

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Contributors

Author: Preethi Bala Balakrishnan
Author: Niccolò Silvestri
Author: Tamara Fernandez-Cabada
Author: Federica Marinaro
Author: Soraia Fernandes
Author: Sergio Fiorito
Author: Mario Miscuglio
Author: David Serantes
Author: Sergiu Ruta
Author: Karen Livesey
Author: Ondrej Hovorka ORCID iD
Author: Roy Chantrell
Author: Teresa Pellegrino

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