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Association between anxiety and hypertension in adults: A systematic review and meta-analysis

Association between anxiety and hypertension in adults: A systematic review and meta-analysis
Association between anxiety and hypertension in adults: A systematic review and meta-analysis

We assessed the association between anxiety and hypertension in adults via a systematic review/meta-analysis. We searched PubMed, Ovid, and PsycINFO through 27 March 2020 with no language or publication type restrictions and systematically contacted study authors for unpublished information/data. We meta-analysed 59 studies including a total of 4,012,775 participants. Study quality was rated with the Newcastle-Ottawa Scale and random-effects analyses were performed. A significant anxiety-hypertension association was found in cross-sectional (OR = 1.37, 95 % CI = 1.21–1.54) and prospective studies (OR = 1.40, 95 % CI = 1.23–1.59). In sensitivity analyses, results were influenced by method of hypertension diagnosis, but not by study quality, method of anxiety diagnosis, study population, and effect size type. In subgroup analyses, study location, in particular country economic status, but not participant age, influenced the results. Longitudinal data and theoretical literature indicate that anxiety may precede hypertension. These findings have important clinical implications for the early detection and treatment of both anxiety and hypertension. Suggestions for future research are discussed.

Anxiety, High blood pressure, Hypertension, Meta-analysis, Phobia, Systematic review
0149-7634
96-119
Lim, Li-faye
4e6f0941-4777-4319-bd11-79916998b054
Solmi, Marco
256504f2-483a-4b42-bfab-081c6a617867
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Lim, Li-faye
4e6f0941-4777-4319-bd11-79916998b054
Solmi, Marco
256504f2-483a-4b42-bfab-081c6a617867
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb

Lim, Li-faye, Solmi, Marco and Cortese, Samuele (2021) Association between anxiety and hypertension in adults: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 131, 96-119. (doi:10.1016/j.neubiorev.2021.08.031).

Record type: Article

Abstract

We assessed the association between anxiety and hypertension in adults via a systematic review/meta-analysis. We searched PubMed, Ovid, and PsycINFO through 27 March 2020 with no language or publication type restrictions and systematically contacted study authors for unpublished information/data. We meta-analysed 59 studies including a total of 4,012,775 participants. Study quality was rated with the Newcastle-Ottawa Scale and random-effects analyses were performed. A significant anxiety-hypertension association was found in cross-sectional (OR = 1.37, 95 % CI = 1.21–1.54) and prospective studies (OR = 1.40, 95 % CI = 1.23–1.59). In sensitivity analyses, results were influenced by method of hypertension diagnosis, but not by study quality, method of anxiety diagnosis, study population, and effect size type. In subgroup analyses, study location, in particular country economic status, but not participant age, influenced the results. Longitudinal data and theoretical literature indicate that anxiety may precede hypertension. These findings have important clinical implications for the early detection and treatment of both anxiety and hypertension. Suggestions for future research are discussed.

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Association between anxiety and hypertension in adults A systematic review and meta-analysis - Accepted Manuscript
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Accepted/In Press date: 31 August 2021
Published date: 1 December 2021
Keywords: Anxiety, High blood pressure, Hypertension, Meta-analysis, Phobia, Systematic review

Identifiers

Local EPrints ID: 453380
URI: http://eprints.soton.ac.uk/id/eprint/453380
ISSN: 0149-7634
PURE UUID: aad0d7a0-a76d-42b2-abe2-48111c073e08
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 13 Jan 2022 18:17
Last modified: 17 Mar 2024 06:52

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Contributors

Author: Li-faye Lim
Author: Marco Solmi
Author: Samuele Cortese ORCID iD

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