OPINION ARTICLE Open Access Quantitative SPECT: the time is now
OPINION ARTICLE Open Access Quantitative SPECT: the time is now
Background
Quantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative measures to absolute quantification in terms of activity concentration, and yet further to normalised uptake using the standard uptake value (SUV). This expansion of quantitative SPECT has the potential to be a useful tool in the nuclear medicine armoury, but key factors must be addressed before it can meet its full potential.
Discussion
Quantitative SPECT should address an unmet clinical need and give metrics that are clinically meaningful. Using the technique in a similar manner to PET with longitudinal assessments of disease in terms of SUV is one example that meets these criteria. Having metrics that are evaluated to ensure that they are correct, that are optimised to maximise their sensitivity, and that are transferrable to allow multi-centre learning and applicability to all users of the technology are other areas of quantitative SPECT that need to be addressed and that have specific challenges associated with them. Finally, ensuring quantitative SPECT is cost-effective in times when healthcare budgets are being squeezed is also very important.
Conclusion
Quantitative SPECT offers the possibility to continue and expand the potential of quantitative nuclear medicine applications. The time is now to ensure that our community works together to make this potential a reality.
Dickson, John
627f7f54-97e9-4cc1-812c-728c3973265d
Ross, James, Clark
01f0b1a4-7f20-4283-b0b4-6b9c8534170e
Voo, Stefan
6be8a8b6-f46c-4f06-b992-143b33ee60c4
4 March 2019
Dickson, John
627f7f54-97e9-4cc1-812c-728c3973265d
Ross, James, Clark
01f0b1a4-7f20-4283-b0b4-6b9c8534170e
Voo, Stefan
6be8a8b6-f46c-4f06-b992-143b33ee60c4
Dickson, John, Ross, James, Clark and Voo, Stefan
(2019)
OPINION ARTICLE Open Access Quantitative SPECT: the time is now.
EJNMMI Physics, 6, [4].
(doi:10.1186/s40658-019-0241-3).
Abstract
Background
Quantification is one of the key benefits of nuclear medicine imaging. Recently, driven by the demand for post radionuclide therapy imaging, quantitative SPECT has moved from relative and semiquantitative measures to absolute quantification in terms of activity concentration, and yet further to normalised uptake using the standard uptake value (SUV). This expansion of quantitative SPECT has the potential to be a useful tool in the nuclear medicine armoury, but key factors must be addressed before it can meet its full potential.
Discussion
Quantitative SPECT should address an unmet clinical need and give metrics that are clinically meaningful. Using the technique in a similar manner to PET with longitudinal assessments of disease in terms of SUV is one example that meets these criteria. Having metrics that are evaluated to ensure that they are correct, that are optimised to maximise their sensitivity, and that are transferrable to allow multi-centre learning and applicability to all users of the technology are other areas of quantitative SPECT that need to be addressed and that have specific challenges associated with them. Finally, ensuring quantitative SPECT is cost-effective in times when healthcare budgets are being squeezed is also very important.
Conclusion
Quantitative SPECT offers the possibility to continue and expand the potential of quantitative nuclear medicine applications. The time is now to ensure that our community works together to make this potential a reality.
Text
s40658-019-0241-3
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Published date: 4 March 2019
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Local EPrints ID: 453595
URI: http://eprints.soton.ac.uk/id/eprint/453595
PURE UUID: d1c0c85b-25be-4454-9f1a-2232f951a23a
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Date deposited: 20 Jan 2022 17:34
Last modified: 17 Mar 2024 04:03
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Author:
John Dickson
Author:
Stefan Voo
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