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Leukotriene antagonists and synthesis inhibitors: New directions in asthma therapy

Leukotriene antagonists and synthesis inhibitors: New directions in asthma therapy
Leukotriene antagonists and synthesis inhibitors: New directions in asthma therapy

This article briefly reviews the advances in our understanding of asthma with a particular focus on the role of inflammation, before providing a concise overview of current knowledge of leukotrienes in the pathophysiology of the disease. The development of leukotriene receptor antagonists and synthesis inhibitors is briefly described; and acute exercise, allergen, and aspirin challenge studies with these agents are reviewed. Clinical studies with leukotriene antagonists and inhibitors have confirmed the central role of leukotrienes in asthma pathophysiology. In conclusion, we suggest that the new generation of leukotriene receptor antagonists may be suitable as first-line therapy in patients with mild to moderate asthma. Further studies are required to determine whether the leukotriene synthesis inhibitors will be equally effective or provide any additional antiinflammatory benefit.

5-lipoxygenase inhibitors, 5-lipoxygenase-activating protein inhibitors, asthma, leukotriene B antagonists, leukotriene D antagonists, leukotrienes
0091-6749
1-13
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bradding, Peter
9cbfd3d1-1bf2-484f-849f-0bf4ffbacc19
Sampson, Anthony P.
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bradding, Peter
9cbfd3d1-1bf2-484f-849f-0bf4ffbacc19
Sampson, Anthony P.
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60

Holgate, Stephen T., Bradding, Peter and Sampson, Anthony P. (1996) Leukotriene antagonists and synthesis inhibitors: New directions in asthma therapy. Journal of Allergy and Clinical Immunology, 98 (1), 1-13. (doi:10.1016/S0091-6749(96)70220-8).

Record type: Article

Abstract

This article briefly reviews the advances in our understanding of asthma with a particular focus on the role of inflammation, before providing a concise overview of current knowledge of leukotrienes in the pathophysiology of the disease. The development of leukotriene receptor antagonists and synthesis inhibitors is briefly described; and acute exercise, allergen, and aspirin challenge studies with these agents are reviewed. Clinical studies with leukotriene antagonists and inhibitors have confirmed the central role of leukotrienes in asthma pathophysiology. In conclusion, we suggest that the new generation of leukotriene receptor antagonists may be suitable as first-line therapy in patients with mild to moderate asthma. Further studies are required to determine whether the leukotriene synthesis inhibitors will be equally effective or provide any additional antiinflammatory benefit.

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More information

Published date: 1996
Additional Information: Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
Keywords: 5-lipoxygenase inhibitors, 5-lipoxygenase-activating protein inhibitors, asthma, leukotriene B antagonists, leukotriene D antagonists, leukotrienes

Identifiers

Local EPrints ID: 453665
URI: http://eprints.soton.ac.uk/id/eprint/453665
ISSN: 0091-6749
PURE UUID: d89a546e-2fc7-46e6-97b6-ea366fac11a6
ORCID for Anthony P. Sampson: ORCID iD orcid.org/0009-0008-9653-8935

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Date deposited: 20 Jan 2022 17:45
Last modified: 17 Mar 2024 02:43

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Author: Peter Bradding

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