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Leukotriene receptor antagonists in asthma therapy

Leukotriene receptor antagonists in asthma therapy
Leukotriene receptor antagonists in asthma therapy

In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but reservations about their use for asthma therapy center on two main issues: the heterogeneity of patient responses and their reduced potency relative to other asthma medications. For example, leukotriene receptor antagonists also have been shown to be less efficacious than inhaled corticosteroids for several end points, including symptom relief, reduced markers of inflammation, and improved pulmonary function. This review explores several underappreciated aspects of asthma therapy: heterogeneity of patient responses to medication, the failure of symptoms to correlate with commonly used end points, and the potential of delivery to distal airways for producing important and novel benefits.

Asthma symptoms, Distal airways, Dyspnea, End points, Leukotriene receptor antagonists, Pulmonary function
0091-6749
S62-S70
Peters, Stephen P.
a29dca99-b7fb-4747-876f-3027d6b85fd8
Hamid, Qutayba
9046e6d8-71d6-4214-9aee-5e54f45263bc
Moqbel, Redwan
3e7ec87b-a8fd-4dca-9d8f-1ccf13697bed
Sampson, Anthony
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60
Peters-Golden, Marc
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Leff, Jon
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Pizzichini, Emilio
f209bca9-4130-4eec-bc7d-4be01383d531
Edelman, Jon
3c0be1c0-b3fb-4d18-ae9a-8f00ee8ec42f
Liu, Mark
280a745f-761e-4059-a590-1ac580d83eba
Bisgaard, Hans
9c218eab-ee81-4fbf-97db-c0352a694491
Henderson, Bill
3005627a-1d12-48b3-a9b8-59a27e60fb87
Peters, Stephen P.
a29dca99-b7fb-4747-876f-3027d6b85fd8
Hamid, Qutayba
9046e6d8-71d6-4214-9aee-5e54f45263bc
Moqbel, Redwan
3e7ec87b-a8fd-4dca-9d8f-1ccf13697bed
Sampson, Anthony
4ca76f6f-ff35-425d-a7e7-c2bd2ea2df60
Peters-Golden, Marc
c097a031-7294-4755-9a0d-965e58ca4e20
Leff, Jon
907b86f2-880a-446a-b015-ac33d8bba07d
Pizzichini, Emilio
f209bca9-4130-4eec-bc7d-4be01383d531
Edelman, Jon
3c0be1c0-b3fb-4d18-ae9a-8f00ee8ec42f
Liu, Mark
280a745f-761e-4059-a590-1ac580d83eba
Bisgaard, Hans
9c218eab-ee81-4fbf-97db-c0352a694491
Henderson, Bill
3005627a-1d12-48b3-a9b8-59a27e60fb87

Peters, Stephen P., Hamid, Qutayba, Moqbel, Redwan, Sampson, Anthony, Peters-Golden, Marc, Leff, Jon, Pizzichini, Emilio, Edelman, Jon, Liu, Mark, Bisgaard, Hans and Henderson, Bill (2003) Leukotriene receptor antagonists in asthma therapy. Journal of Allergy and Clinical Immunology, 111 (1 SUPPL.), S62-S70. (doi:10.1067/mai.2003.21).

Record type: Article

Abstract

In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but reservations about their use for asthma therapy center on two main issues: the heterogeneity of patient responses and their reduced potency relative to other asthma medications. For example, leukotriene receptor antagonists also have been shown to be less efficacious than inhaled corticosteroids for several end points, including symptom relief, reduced markers of inflammation, and improved pulmonary function. This review explores several underappreciated aspects of asthma therapy: heterogeneity of patient responses to medication, the failure of symptoms to correlate with commonly used end points, and the potential of delivery to distal airways for producing important and novel benefits.

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More information

Published date: 1 January 2003
Additional Information: Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
Keywords: Asthma symptoms, Distal airways, Dyspnea, End points, Leukotriene receptor antagonists, Pulmonary function

Identifiers

Local EPrints ID: 453703
URI: http://eprints.soton.ac.uk/id/eprint/453703
ISSN: 0091-6749
PURE UUID: ffc2e68f-fd3a-4b82-8231-b44e1e1db68a
ORCID for Anthony Sampson: ORCID iD orcid.org/0009-0008-9653-8935

Catalogue record

Date deposited: 20 Jan 2022 17:48
Last modified: 17 Mar 2024 02:43

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Contributors

Author: Stephen P. Peters
Author: Qutayba Hamid
Author: Redwan Moqbel
Author: Anthony Sampson ORCID iD
Author: Marc Peters-Golden
Author: Jon Leff
Author: Emilio Pizzichini
Author: Jon Edelman
Author: Mark Liu
Author: Hans Bisgaard
Author: Bill Henderson

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