Leukotriene receptor antagonists in asthma therapy
Leukotriene receptor antagonists in asthma therapy
In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but reservations about their use for asthma therapy center on two main issues: the heterogeneity of patient responses and their reduced potency relative to other asthma medications. For example, leukotriene receptor antagonists also have been shown to be less efficacious than inhaled corticosteroids for several end points, including symptom relief, reduced markers of inflammation, and improved pulmonary function. This review explores several underappreciated aspects of asthma therapy: heterogeneity of patient responses to medication, the failure of symptoms to correlate with commonly used end points, and the potential of delivery to distal airways for producing important and novel benefits.
Asthma symptoms, Distal airways, Dyspnea, End points, Leukotriene receptor antagonists, Pulmonary function
S62-S70
Peters, Stephen P.
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Hamid, Qutayba
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Moqbel, Redwan
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Sampson, Anthony
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Peters-Golden, Marc
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Leff, Jon
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Pizzichini, Emilio
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Edelman, Jon
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Liu, Mark
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Bisgaard, Hans
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Henderson, Bill
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1 January 2003
Peters, Stephen P.
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Hamid, Qutayba
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Moqbel, Redwan
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Sampson, Anthony
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Peters-Golden, Marc
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Leff, Jon
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Pizzichini, Emilio
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Edelman, Jon
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Liu, Mark
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Bisgaard, Hans
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Henderson, Bill
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Peters, Stephen P., Hamid, Qutayba, Moqbel, Redwan, Sampson, Anthony, Peters-Golden, Marc, Leff, Jon, Pizzichini, Emilio, Edelman, Jon, Liu, Mark, Bisgaard, Hans and Henderson, Bill
(2003)
Leukotriene receptor antagonists in asthma therapy.
Journal of Allergy and Clinical Immunology, 111 (1 SUPPL.), .
(doi:10.1067/mai.2003.21).
Abstract
In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but reservations about their use for asthma therapy center on two main issues: the heterogeneity of patient responses and their reduced potency relative to other asthma medications. For example, leukotriene receptor antagonists also have been shown to be less efficacious than inhaled corticosteroids for several end points, including symptom relief, reduced markers of inflammation, and improved pulmonary function. This review explores several underappreciated aspects of asthma therapy: heterogeneity of patient responses to medication, the failure of symptoms to correlate with commonly used end points, and the potential of delivery to distal airways for producing important and novel benefits.
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Published date: 1 January 2003
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Copyright 2021 Elsevier B.V., All rights reserved.
Keywords:
Asthma symptoms, Distal airways, Dyspnea, End points, Leukotriene receptor antagonists, Pulmonary function
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Local EPrints ID: 453703
URI: http://eprints.soton.ac.uk/id/eprint/453703
ISSN: 0091-6749
PURE UUID: ffc2e68f-fd3a-4b82-8231-b44e1e1db68a
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Date deposited: 20 Jan 2022 17:48
Last modified: 17 Mar 2024 02:43
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Author:
Stephen P. Peters
Author:
Qutayba Hamid
Author:
Redwan Moqbel
Author:
Marc Peters-Golden
Author:
Jon Leff
Author:
Emilio Pizzichini
Author:
Jon Edelman
Author:
Mark Liu
Author:
Hans Bisgaard
Author:
Bill Henderson
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