Effect of combination antiretroviral therapy on human immunodeficiency virus 1 specific antibody responses in subtype-C infected children
Effect of combination antiretroviral therapy on human immunodeficiency virus 1 specific antibody responses in subtype-C infected children
Protective antibody responses to human immunodeficiency virus (HIV)-1 infection evolve only in a fraction of infected individuals by developing broadly neutralizing antibodies (bnAbs) and/or effector functions such as antibody-dependent cellular cytotoxicity (ADCC). HIV-1 chronically infected adults and children on combination antiretroviral therapy (cART) showed a reduction in ADCC activity and improvement in HIV-1 specific neutralizing antibody (nAb) responses. Early initiation of cART in infected adults is found to be beneficial in reducing the viral load and delaying disease progression. Herein, we longitudinally evaluated the effect of cART on HIV-1 specific plasma ADCC and nAb responses in a cohort of 20 perinatally HIV-1 subtype-C infected infants and children ≤2 years of age, pre-cART and up to 1 year post-cART initiation. Significant reductions in HIV-1 specific plasma ADCC responses to subtype-C and subtype-B viruses and improvement in HIV-1 neutralization were observed in HIV-1 infected children 1 year post-cART initiation. A positive correlation between reduction in viral load and the loss of ADCC response was observed. This study provides information aiding the understanding of the effects of early initiation of cART on antibody effector functions and viral neutralization in HIV-1 infected children, which needs to be further evaluated in large cohorts of HIV-1 infected children on cART to plan future intervention strategies.
Anti-HIV Agents/therapeutic use, Antibodies, Neutralizing/blood, Antibody-Dependent Cell Cytotoxicity/drug effects, Antiretroviral Therapy, Highly Active, Child, Preschool, Cohort Studies, Dideoxynucleosides/therapeutic use, Drug Combinations, HIV Antibodies/blood, HIV Infections/drug therapy, HIV-1/classification, Humans, Infant, Lamivudine/therapeutic use, Lopinavir, Ritonavir, Viral Load, Zidovudine/therapeutic use
1289-1299
Kumar, Sanjeev
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Batra, Himanshu
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Singh, Swarandeep
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Chawla, Himanshi
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Singh, Ravinder
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Katpara, Sanket
8d83d2d8-b35a-43ec-995a-cbb29b288f67
Hussain, Abdul Wahid
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Das, Bimal Kumar
dc79149c-9b26-44f1-8b6f-4b6faa1540e6
Lodha, Rakesh
cdfb40fa-c83b-4ec0-bfe2-33a589209a62
Kabra, Sushil Kumar
ba01266c-dc15-497d-8555-64e776d115ca
Luthra, Kalpana
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1 December 2020
Kumar, Sanjeev
72adbe62-7c8b-4430-aab6-6e54e94b2a91
Batra, Himanshu
f8755e80-38a0-41bd-815b-1db071283f2e
Singh, Swarandeep
3b6a2cb8-67ab-4b93-a648-cca8394bcba8
Chawla, Himanshi
07b9e983-4c35-4314-999d-fe3222a6c03b
Singh, Ravinder
4f8eac9d-8675-4603-ba25-796eec5f003f
Katpara, Sanket
8d83d2d8-b35a-43ec-995a-cbb29b288f67
Hussain, Abdul Wahid
42bf063f-332b-4edf-bf09-4fee9f8720c4
Das, Bimal Kumar
dc79149c-9b26-44f1-8b6f-4b6faa1540e6
Lodha, Rakesh
cdfb40fa-c83b-4ec0-bfe2-33a589209a62
Kabra, Sushil Kumar
ba01266c-dc15-497d-8555-64e776d115ca
Luthra, Kalpana
40fc2436-ee10-4d8b-a414-70e7214a2bf2
Kumar, Sanjeev, Batra, Himanshu, Singh, Swarandeep, Chawla, Himanshi, Singh, Ravinder, Katpara, Sanket, Hussain, Abdul Wahid, Das, Bimal Kumar, Lodha, Rakesh, Kabra, Sushil Kumar and Luthra, Kalpana
(2020)
Effect of combination antiretroviral therapy on human immunodeficiency virus 1 specific antibody responses in subtype-C infected children.
The Journal of General Virology, 101 (12), .
(doi:10.1099/jgv.0.001480).
Abstract
Protective antibody responses to human immunodeficiency virus (HIV)-1 infection evolve only in a fraction of infected individuals by developing broadly neutralizing antibodies (bnAbs) and/or effector functions such as antibody-dependent cellular cytotoxicity (ADCC). HIV-1 chronically infected adults and children on combination antiretroviral therapy (cART) showed a reduction in ADCC activity and improvement in HIV-1 specific neutralizing antibody (nAb) responses. Early initiation of cART in infected adults is found to be beneficial in reducing the viral load and delaying disease progression. Herein, we longitudinally evaluated the effect of cART on HIV-1 specific plasma ADCC and nAb responses in a cohort of 20 perinatally HIV-1 subtype-C infected infants and children ≤2 years of age, pre-cART and up to 1 year post-cART initiation. Significant reductions in HIV-1 specific plasma ADCC responses to subtype-C and subtype-B viruses and improvement in HIV-1 neutralization were observed in HIV-1 infected children 1 year post-cART initiation. A positive correlation between reduction in viral load and the loss of ADCC response was observed. This study provides information aiding the understanding of the effects of early initiation of cART on antibody effector functions and viral neutralization in HIV-1 infected children, which needs to be further evaluated in large cohorts of HIV-1 infected children on cART to plan future intervention strategies.
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Published date: 1 December 2020
Keywords:
Anti-HIV Agents/therapeutic use, Antibodies, Neutralizing/blood, Antibody-Dependent Cell Cytotoxicity/drug effects, Antiretroviral Therapy, Highly Active, Child, Preschool, Cohort Studies, Dideoxynucleosides/therapeutic use, Drug Combinations, HIV Antibodies/blood, HIV Infections/drug therapy, HIV-1/classification, Humans, Infant, Lamivudine/therapeutic use, Lopinavir, Ritonavir, Viral Load, Zidovudine/therapeutic use
Identifiers
Local EPrints ID: 453731
URI: http://eprints.soton.ac.uk/id/eprint/453731
ISSN: 0022-1317
PURE UUID: 79dc9a3d-0d1a-46f2-9005-b520b8b0b39a
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Date deposited: 21 Jan 2022 17:41
Last modified: 17 Mar 2024 03:57
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Contributors
Author:
Sanjeev Kumar
Author:
Himanshu Batra
Author:
Swarandeep Singh
Author:
Ravinder Singh
Author:
Sanket Katpara
Author:
Abdul Wahid Hussain
Author:
Bimal Kumar Das
Author:
Rakesh Lodha
Author:
Sushil Kumar Kabra
Author:
Kalpana Luthra
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