The University of Southampton
University of Southampton Institutional Repository

Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection

Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection
Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection

Broadly neutralizing antibodies (bnAbs) develop in a subset of HIV-1 infected individuals over 2-3 years of infection. Infected infants develop plasma bnAbs frequently and as early as 1-year post-infection suggesting factors governing bnAb induction in infants are distinct from adults. Understanding viral characteristics in infected infants with early bnAb responses will provide key information about antigenic triggers driving B cell maturation pathways towards induction of bnAbs. Herein, we evaluate the presence of plasma bnAbs in a cohort of 51 HIV-1 clade-C infected infants and identify viral factors associated with early bnAb responses. Plasma bnAbs targeting V2-apex on the env are predominant in infant elite and broad neutralizers. Circulating viral variants in infant elite neutralizers are susceptible to V2-apex bnAbs. In infant elite neutralizers, multivariant infection is associated with plasma bnAbs targeting diverse autologous viruses. Our data provides information supportive of polyvalent vaccination approaches capable of inducing V2-apex bnAbs against HIV-1.

Antibodies, Neutralizing/blood, Cohort Studies, Female, HIV Antibodies/immunology, HIV Infections/immunology, HIV-1/immunology, Humans, Infant, Infectious Disease Transmission, Vertical, Male, Vaccination, env Gene Products, Human Immunodeficiency Virus/immunology
2041-1723
Mishra, Nitesh
296376dd-f36f-4b32-a250-ff56067067b7
Sharma, Shaifali
cc9baac5-68d3-42c2-8feb-88098d84420f
Dobhal, Ayushman
ac13aa18-8b42-4706-b6ab-254e211e224e
Kumar, Sanjeev
72adbe62-7c8b-4430-aab6-6e54e94b2a91
Chawla, Himanshi
07b9e983-4c35-4314-999d-fe3222a6c03b
Singh, Ravinder
4f8eac9d-8675-4603-ba25-796eec5f003f
Makhdoomi, Muzamil Ashraf
19dea238-9359-4412-aae1-df8e74812525
Das, Bimal Kumar
dc79149c-9b26-44f1-8b6f-4b6faa1540e6
Lodha, Rakesh
cdfb40fa-c83b-4ec0-bfe2-33a589209a62
Kabra, Sushil Kumar
ba01266c-dc15-497d-8555-64e776d115ca
Luthra, Kalpana
40fc2436-ee10-4d8b-a414-70e7214a2bf2
Mishra, Nitesh
296376dd-f36f-4b32-a250-ff56067067b7
Sharma, Shaifali
cc9baac5-68d3-42c2-8feb-88098d84420f
Dobhal, Ayushman
ac13aa18-8b42-4706-b6ab-254e211e224e
Kumar, Sanjeev
72adbe62-7c8b-4430-aab6-6e54e94b2a91
Chawla, Himanshi
07b9e983-4c35-4314-999d-fe3222a6c03b
Singh, Ravinder
4f8eac9d-8675-4603-ba25-796eec5f003f
Makhdoomi, Muzamil Ashraf
19dea238-9359-4412-aae1-df8e74812525
Das, Bimal Kumar
dc79149c-9b26-44f1-8b6f-4b6faa1540e6
Lodha, Rakesh
cdfb40fa-c83b-4ec0-bfe2-33a589209a62
Kabra, Sushil Kumar
ba01266c-dc15-497d-8555-64e776d115ca
Luthra, Kalpana
40fc2436-ee10-4d8b-a414-70e7214a2bf2

Mishra, Nitesh, Sharma, Shaifali, Dobhal, Ayushman, Kumar, Sanjeev, Chawla, Himanshi, Singh, Ravinder, Makhdoomi, Muzamil Ashraf, Das, Bimal Kumar, Lodha, Rakesh, Kabra, Sushil Kumar and Luthra, Kalpana (2020) Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection. Nature Communications, 11 (1), [4409]. (doi:10.1038/s41467-020-18225-x).

Record type: Article

Abstract

Broadly neutralizing antibodies (bnAbs) develop in a subset of HIV-1 infected individuals over 2-3 years of infection. Infected infants develop plasma bnAbs frequently and as early as 1-year post-infection suggesting factors governing bnAb induction in infants are distinct from adults. Understanding viral characteristics in infected infants with early bnAb responses will provide key information about antigenic triggers driving B cell maturation pathways towards induction of bnAbs. Herein, we evaluate the presence of plasma bnAbs in a cohort of 51 HIV-1 clade-C infected infants and identify viral factors associated with early bnAb responses. Plasma bnAbs targeting V2-apex on the env are predominant in infant elite and broad neutralizers. Circulating viral variants in infant elite neutralizers are susceptible to V2-apex bnAbs. In infant elite neutralizers, multivariant infection is associated with plasma bnAbs targeting diverse autologous viruses. Our data provides information supportive of polyvalent vaccination approaches capable of inducing V2-apex bnAbs against HIV-1.

Text
s41467-020-18225-x - Version of Record
Available under License Creative Commons Attribution.
Download (1MB)

More information

Published date: 2 September 2020
Keywords: Antibodies, Neutralizing/blood, Cohort Studies, Female, HIV Antibodies/immunology, HIV Infections/immunology, HIV-1/immunology, Humans, Infant, Infectious Disease Transmission, Vertical, Male, Vaccination, env Gene Products, Human Immunodeficiency Virus/immunology

Identifiers

Local EPrints ID: 453750
URI: http://eprints.soton.ac.uk/id/eprint/453750
ISSN: 2041-1723
PURE UUID: 92df4abf-eba4-4b73-af25-0b3ce1d84df3
ORCID for Himanshi Chawla: ORCID iD orcid.org/0000-0001-9828-6593

Catalogue record

Date deposited: 24 Jan 2022 17:35
Last modified: 17 Mar 2024 03:57

Export record

Altmetrics

Contributors

Author: Nitesh Mishra
Author: Shaifali Sharma
Author: Ayushman Dobhal
Author: Sanjeev Kumar
Author: Himanshi Chawla ORCID iD
Author: Ravinder Singh
Author: Muzamil Ashraf Makhdoomi
Author: Bimal Kumar Das
Author: Rakesh Lodha
Author: Sushil Kumar Kabra
Author: Kalpana Luthra

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×