Fractional flow reserve derived from coronary computed tomography: where are we now and where are we heading?
Fractional flow reserve derived from coronary computed tomography: where are we now and where are we heading?
Computed tomography coronary angiography is emerging as the preferred diagnostic tool for patients with chest pain. Additional knowledge of the extent and distribution of myocardial ischemia enables tailored patient management. Computed tomography-derived fractional flow reserve (FFRCT) employs computed tomography coronary angiography raw data processed via complex computational fluid dynamics and produces a surrogate of the invasive fractional flow reserve (FFR) thus delivering anatomical and physiological assessment in a single test. FFRCT has been extensively validated against invasive FFR and observational clinical studies have consistently demonstrated its utility as gatekeeper to invasive angiography while also reducing downstream clinical events and costs. Novel workstation-based models of estimating FFR are now being tested. Ongoing and future research results will define their role in clinical practice.
acute coronary syndrome, angina, atherosclerosis, chest pain, chronic coronary syndrome, computed tomography, computed tomography coronary angiography, computed tomography fractional flow reserve
723-741
Gabara, Lavinia
be0801da-c44d-48e1-a939-4f2dbe249b8f
Hinton, Jonathan
2e15a197-77ec-4f89-9b08-f632800837f0
Gilpin, Thomas Russell
cb88df13-8ea5-469a-964a-26b593c1888c
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
1 July 2021
Gabara, Lavinia
be0801da-c44d-48e1-a939-4f2dbe249b8f
Hinton, Jonathan
2e15a197-77ec-4f89-9b08-f632800837f0
Gilpin, Thomas Russell
cb88df13-8ea5-469a-964a-26b593c1888c
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Gabara, Lavinia, Hinton, Jonathan, Gilpin, Thomas Russell and Curzen, Nick
(2021)
Fractional flow reserve derived from coronary computed tomography: where are we now and where are we heading?
Future Cardiology, 17 (4), .
(doi:10.2217/fca-2020-0058).
Abstract
Computed tomography coronary angiography is emerging as the preferred diagnostic tool for patients with chest pain. Additional knowledge of the extent and distribution of myocardial ischemia enables tailored patient management. Computed tomography-derived fractional flow reserve (FFRCT) employs computed tomography coronary angiography raw data processed via complex computational fluid dynamics and produces a surrogate of the invasive fractional flow reserve (FFR) thus delivering anatomical and physiological assessment in a single test. FFRCT has been extensively validated against invasive FFR and observational clinical studies have consistently demonstrated its utility as gatekeeper to invasive angiography while also reducing downstream clinical events and costs. Novel workstation-based models of estimating FFR are now being tested. Ongoing and future research results will define their role in clinical practice.
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e-pub ahead of print date: 21 September 2020
Published date: 1 July 2021
Keywords:
acute coronary syndrome, angina, atherosclerosis, chest pain, chronic coronary syndrome, computed tomography, computed tomography coronary angiography, computed tomography fractional flow reserve
Identifiers
Local EPrints ID: 453788
URI: http://eprints.soton.ac.uk/id/eprint/453788
ISSN: 1479-6678
PURE UUID: 984eb425-9b18-40b2-b8d0-d79e869f4d83
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Date deposited: 24 Jan 2022 17:49
Last modified: 17 Mar 2024 03:02
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Author:
Lavinia Gabara
Author:
Jonathan Hinton
Author:
Thomas Russell Gilpin
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