Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia
Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia
Although Streptococcus pneumoniae is a leading cause of childhood disease in South East Asia, little has previously been reported regarding the epidemiology of invasive pneumococcal disease in Malaysia and very few studies have explored pneumococcal epidemiology using multilocus sequence typing (MLST). Here we describe serotype, multilocus sequence type (ST), and penicillin susceptibility of thirty pneumococcal invasive disease isolates received by the University of Malaya Medical Centre between February 2000 and January 2007 and relate this to the serotypes included in current pneumococcal conjugate vaccines. A high level of diversity was observed; fourteen serotypes and 26 sequence types (ST), (11 of which were not previously described) were detected from 30 isolates. Penicillin non-susceptible pneumococci accounted for 33% of isolates. The extent of molecular heterogeneity within carried and disease-causing Malaysian pneumococci remains unknown. Larger surveillance and epidemiological studies are now required in this region to provide robust evidence on which to base future vaccine policy.
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/therapeutic use, Child, Child, Preschool, Clone Cells, Humans, Infant, Infant, Newborn, Malaysia/epidemiology, Middle Aged, Multilocus Sequence Typing, Penicillins/therapeutic use, Pneumococcal Infections/drug therapy, Pneumococcal Vaccines/administration & dosage, Serotyping, Streptococcus pneumoniae/classification, Vaccines, Conjugate, beta-Lactam Resistance
e97912
Jefferies, Johanna M
d3c7f86b-c08e-4c8f-9ce1-c2ac5a511746
Mohd Yusof, Mohd Yasim
5566b8d7-bac9-45a2-b7e2-9eb470ffc479
Devi Sekaran, Shamala
b8d4064f-9f7c-4322-b2a5-8553735d8fd5
Clarke, Stuart C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
2014
Jefferies, Johanna M
d3c7f86b-c08e-4c8f-9ce1-c2ac5a511746
Mohd Yusof, Mohd Yasim
5566b8d7-bac9-45a2-b7e2-9eb470ffc479
Devi Sekaran, Shamala
b8d4064f-9f7c-4322-b2a5-8553735d8fd5
Clarke, Stuart C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Jefferies, Johanna M, Mohd Yusof, Mohd Yasim, Devi Sekaran, Shamala and Clarke, Stuart C
(2014)
Novel clones of Streptococcus pneumoniae causing invasive disease in Malaysia.
PLoS ONE, 9 (6), .
(doi:10.1371/journal.pone.0097912).
Abstract
Although Streptococcus pneumoniae is a leading cause of childhood disease in South East Asia, little has previously been reported regarding the epidemiology of invasive pneumococcal disease in Malaysia and very few studies have explored pneumococcal epidemiology using multilocus sequence typing (MLST). Here we describe serotype, multilocus sequence type (ST), and penicillin susceptibility of thirty pneumococcal invasive disease isolates received by the University of Malaya Medical Centre between February 2000 and January 2007 and relate this to the serotypes included in current pneumococcal conjugate vaccines. A high level of diversity was observed; fourteen serotypes and 26 sequence types (ST), (11 of which were not previously described) were detected from 30 isolates. Penicillin non-susceptible pneumococci accounted for 33% of isolates. The extent of molecular heterogeneity within carried and disease-causing Malaysian pneumococci remains unknown. Larger surveillance and epidemiological studies are now required in this region to provide robust evidence on which to base future vaccine policy.
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Published date: 2014
Keywords:
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/therapeutic use, Child, Child, Preschool, Clone Cells, Humans, Infant, Infant, Newborn, Malaysia/epidemiology, Middle Aged, Multilocus Sequence Typing, Penicillins/therapeutic use, Pneumococcal Infections/drug therapy, Pneumococcal Vaccines/administration & dosage, Serotyping, Streptococcus pneumoniae/classification, Vaccines, Conjugate, beta-Lactam Resistance
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Local EPrints ID: 453854
URI: http://eprints.soton.ac.uk/id/eprint/453854
ISSN: 1932-6203
PURE UUID: d0c19aab-1aec-4d2f-a06d-117bac1b2828
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Date deposited: 25 Jan 2022 17:40
Last modified: 17 Mar 2024 03:07
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Author:
Johanna M Jefferies
Author:
Mohd Yasim Mohd Yusof
Author:
Shamala Devi Sekaran
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