When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer

Chakravarthy, Ankur, Henderson, S and Fenton, TR (2014) When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer. Molecular Cellular Oncology, 1 (1), [29914]. (doi:10.4161/mco.29914).

Record type: Article

Abstract

The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.

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Published date: 1 August 2014

Additional Information: Copyright copyright 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

Keywords: APOBEC, HPV, PIK3CA, cancer, mutagenesis