Chapter One - The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer - Understanding the Basis of a Rapidly Evolving Disease
Chapter One - The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer - Understanding the Basis of a Rapidly Evolving Disease
Human papillomavirus (HPV) has been shown to represent a major independent risk factor for head and neck squamous cell cancer, in particular for oropharyngeal carcinoma. This type of cancer is rapidly evolving in the Western world, with rising trends particularly in the young, and represents a distinct epidemiological, clinical, and molecular entity. It is the aim of this review to give a detailed description of genomic, epigenomic, transcriptomic, and posttranscriptional changes that underlie the phenotype of this deadly disease. The review will also link these changes and examine what is known about the interactions between the host genome and viral genome, and investigate changes specific for the viral genome. These data are then integrated into an updated model of HPV-induced head and neck carcinogenesis.
Cancer, Epigenetics, Genomics, HNSCC, HPV, Methylation, Oropharynx, Papillomavirus, SCC
1-56
Lechner, M
19c72359-7dc0-435c-817a-f67d4956656f
Fenton, TR
087260ba-f6a1-405a-85df-099d05810a84
9 February 2016
Lechner, M
19c72359-7dc0-435c-817a-f67d4956656f
Fenton, TR
087260ba-f6a1-405a-85df-099d05810a84
Lechner, M and Fenton, TR
(2016)
Chapter One - The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer - Understanding the Basis of a Rapidly Evolving Disease.
In,
Advances in Genetics.
(Advances in Genetics, 93)
Elsevier, .
(doi:10.1016/bs.adgen.2015.12.001).
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Book Section
Abstract
Human papillomavirus (HPV) has been shown to represent a major independent risk factor for head and neck squamous cell cancer, in particular for oropharyngeal carcinoma. This type of cancer is rapidly evolving in the Western world, with rising trends particularly in the young, and represents a distinct epidemiological, clinical, and molecular entity. It is the aim of this review to give a detailed description of genomic, epigenomic, transcriptomic, and posttranscriptional changes that underlie the phenotype of this deadly disease. The review will also link these changes and examine what is known about the interactions between the host genome and viral genome, and investigate changes specific for the viral genome. These data are then integrated into an updated model of HPV-induced head and neck carcinogenesis.
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Published date: 9 February 2016
Keywords:
Cancer, Epigenetics, Genomics, HNSCC, HPV, Methylation, Oropharynx, Papillomavirus, SCC
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Local EPrints ID: 453905
URI: http://eprints.soton.ac.uk/id/eprint/453905
PURE UUID: 4b32c158-f127-4cc3-8e4d-a6aa9e115240
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Date deposited: 25 Jan 2022 17:50
Last modified: 17 Mar 2024 04:11
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Author:
M Lechner
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