The University of Southampton
University of Southampton Institutional Repository

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
Percutaneous muscle biopsy using the Weil-Blakesley conchotome is well established in both clinical and research practice. It is a safe, effective and well tolerated technique. The Weil-Blakesley conchotome has a sharp biting tip with a 4 - 6 mm wide hollow. It is inserted through a 5 - 10 mm skin incision and can be maneuvered for controlled tissue penetration. The tip is opened and closed within the tissue and then rotated through 90 -180° to cut the muscle. The amount of muscle obtained following repeated sampling can vary from 20 mg to 290 mg which can be processed for both histology and molecular studies. The wound needs to be kept dry and vigorous physical activity kept to a minimum for approximately 72 hr although normal levels of activity can restart immediately following the procedure. This procedure is safe and effective when close attention is paid to the selection of subjects, full asepsis and post procedure care. Both right and left vastus lateralis are suitable for biopsy dependent on participant preference.
1940-087X
Patel, Harnish
e1c0826f-d14e-49f3-8049-5b945d185523
Patel, Harnish
e1c0826f-d14e-49f3-8049-5b945d185523

Patel, Harnish (2016) Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome. Journal of Visualized Experiments, 109, [e53075]. (doi:10.3791/53075).

Record type: Article

Abstract

Percutaneous muscle biopsy using the Weil-Blakesley conchotome is well established in both clinical and research practice. It is a safe, effective and well tolerated technique. The Weil-Blakesley conchotome has a sharp biting tip with a 4 - 6 mm wide hollow. It is inserted through a 5 - 10 mm skin incision and can be maneuvered for controlled tissue penetration. The tip is opened and closed within the tissue and then rotated through 90 -180° to cut the muscle. The amount of muscle obtained following repeated sampling can vary from 20 mg to 290 mg which can be processed for both histology and molecular studies. The wound needs to be kept dry and vigorous physical activity kept to a minimum for approximately 72 hr although normal levels of activity can restart immediately following the procedure. This procedure is safe and effective when close attention is paid to the selection of subjects, full asepsis and post procedure care. Both right and left vastus lateralis are suitable for biopsy dependent on participant preference.

This record has no associated files available for download.

More information

Published date: 4 March 2016

Identifiers

Local EPrints ID: 453925
URI: http://eprints.soton.ac.uk/id/eprint/453925
ISSN: 1940-087X
PURE UUID: a5bac95f-7a1b-44f6-8820-7ce70bb65c76
ORCID for Harnish Patel: ORCID iD orcid.org/0000-0002-0081-1802

Catalogue record

Date deposited: 25 Jan 2022 18:15
Last modified: 27 Jan 2022 02:39

Export record

Altmetrics

Contributors

Author: Harnish Patel ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×