Functions and regulation of the 70 kDa ribosomal S6 kinases
Functions and regulation of the 70 kDa ribosomal S6 kinases
The 70 kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients. The S6 kinases have been linked to diverse cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth and survival. Studies in model organisms have highlighted the roles that S6K activity plays in a number of pathologies, including obesity, diabetes, ageing and cancer. The importance of S6K function in human diseases has led to the development of S6K-specific inhibitors by a number of companies, offering the promise of improved tools with which to study these enzymes and potentially the effective targeting of deregulated S6K signalling in patients. Here we review the current literature on the role of S6Ks in the regulation of cell growth, survival and proliferation downstream of various signalling pathways and how their dysregulation contributes to the pathogenesis of human diseases.
Science Technology, Life Sciences Biomedicine, Biochemistry Molecular Biology, Cell Biology, BIOCHEMISTRY MOLECULAR BIOLOGY, CELL BIOLOGY, S6 kinase, Signalling pathways, Translation, Cell growth and survival, Cancer and ageing, INSULIN-RECEPTOR SUBSTRATE-1, MOUSE 3T3 FIBROBLASTS, CAP-BINDING COMPLEX, PROTEIN-KINASE, MAMMALIAN TARGET, CELL-GROWTH, IN-VIVO, PHOSPHORYLATION SITES, LIFE-SPAN, SIGNAL-TRANSDUCTION
47-59
Fenton, TR
087260ba-f6a1-405a-85df-099d05810a84
Gout, IT
7fd0e0ff-a6a5-4579-aea1-fa3c1e80fe23
Fenton, TR
087260ba-f6a1-405a-85df-099d05810a84
Gout, IT
7fd0e0ff-a6a5-4579-aea1-fa3c1e80fe23
Fenton, TR and Gout, IT
(2010)
Functions and regulation of the 70 kDa ribosomal S6 kinases.
International Journal of Biochemistry and Cell Biology, 43 (1), .
(doi:10.1016/j.biocel.2010.09.018).
Abstract
The 70 kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients. The S6 kinases have been linked to diverse cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth and survival. Studies in model organisms have highlighted the roles that S6K activity plays in a number of pathologies, including obesity, diabetes, ageing and cancer. The importance of S6K function in human diseases has led to the development of S6K-specific inhibitors by a number of companies, offering the promise of improved tools with which to study these enzymes and potentially the effective targeting of deregulated S6K signalling in patients. Here we review the current literature on the role of S6Ks in the regulation of cell growth, survival and proliferation downstream of various signalling pathways and how their dysregulation contributes to the pathogenesis of human diseases.
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Accepted/In Press date: 23 September 2010
e-pub ahead of print date: 6 October 2010
Keywords:
Science Technology, Life Sciences Biomedicine, Biochemistry Molecular Biology, Cell Biology, BIOCHEMISTRY MOLECULAR BIOLOGY, CELL BIOLOGY, S6 kinase, Signalling pathways, Translation, Cell growth and survival, Cancer and ageing, INSULIN-RECEPTOR SUBSTRATE-1, MOUSE 3T3 FIBROBLASTS, CAP-BINDING COMPLEX, PROTEIN-KINASE, MAMMALIAN TARGET, CELL-GROWTH, IN-VIVO, PHOSPHORYLATION SITES, LIFE-SPAN, SIGNAL-TRANSDUCTION
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Local EPrints ID: 454030
URI: http://eprints.soton.ac.uk/id/eprint/454030
PURE UUID: ce9ec96c-cee3-450d-91a8-c9bd18b1faae
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Date deposited: 27 Jan 2022 18:48
Last modified: 17 Mar 2024 04:11
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Author:
IT Gout
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