Locus Coeruleus in the pathogenesis of Alzheimer’s Disease: a systematic review
Locus Coeruleus in the pathogenesis of Alzheimer’s Disease: a systematic review
The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer’s Disease (AD) has primarily been related to cholinergic, evidence indicates extensive LC degeneration as its earliest pathological marker. The current study aimed to systematically evaluate current evidence investigating the role of the LC in the pathogenesis of AD. A systematic search of the literature was performed on electronic databases including PubMed and Web of Science. 12 animal, human post-mortem and human imaging studies were included in this review. Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic reviews. Significant associations were identified between LC changes and cognitive decline. Significant reductions in fibre density, neuronal number and LC volume were seen to correlate with other pathological degenerative markers. Current evidence indicates important role of the LC in pathogenesis of AD and suggests its potential in both diagnosis and treatment of AD. This systematic review advances our understanding of the role of the LC in AD by synthesising available evidence, identifying research gaps, highlighting methodological challenges, and making recommendations for future work.
5-22
Chen, Yuqing
ac9f4819-db0f-4305-903e-8eead33d255a
Chen, Teng
b6460d17-215b-48e6-8184-3ccf011c117a
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
7 March 2022
Chen, Yuqing
ac9f4819-db0f-4305-903e-8eead33d255a
Chen, Teng
b6460d17-215b-48e6-8184-3ccf011c117a
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Chen, Yuqing, Chen, Teng and Hou, Ruihua
(2022)
Locus Coeruleus in the pathogenesis of Alzheimer’s Disease: a systematic review.
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 8 (1), , [e12257].
(doi:10.1002/trc2.12257).
Abstract
The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer’s Disease (AD) has primarily been related to cholinergic, evidence indicates extensive LC degeneration as its earliest pathological marker. The current study aimed to systematically evaluate current evidence investigating the role of the LC in the pathogenesis of AD. A systematic search of the literature was performed on electronic databases including PubMed and Web of Science. 12 animal, human post-mortem and human imaging studies were included in this review. Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic reviews. Significant associations were identified between LC changes and cognitive decline. Significant reductions in fibre density, neuronal number and LC volume were seen to correlate with other pathological degenerative markers. Current evidence indicates important role of the LC in pathogenesis of AD and suggests its potential in both diagnosis and treatment of AD. This systematic review advances our understanding of the role of the LC in AD by synthesising available evidence, identifying research gaps, highlighting methodological challenges, and making recommendations for future work.
Text
A D Transl Res Clin Interv - 2022 - Chen - Locus coeruleus
- Version of Record
More information
Accepted/In Press date: 11 June 2021
e-pub ahead of print date: 31 August 2021
Published date: 7 March 2022
Identifiers
Local EPrints ID: 454199
URI: http://eprints.soton.ac.uk/id/eprint/454199
PURE UUID: 65d8a3e0-9c1a-4513-9916-f2aaf4f95292
Catalogue record
Date deposited: 02 Feb 2022 17:45
Last modified: 03 Sep 2022 01:44
Export record
Altmetrics
Contributors
Author:
Yuqing Chen
Author:
Teng Chen
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
