Locus Coeruleus in the pathogenesis of Alzheimer’s Disease: a systematic review
Locus Coeruleus in the pathogenesis of Alzheimer’s Disease: a systematic review
The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic depletion, evidence indicates extensive LC degeneration as its earliest pathological marker. The current study aimed to systematically evaluate current evidence investigating the role of the LC in the pathogenesis of AD. A systematic search of the literature was performed on electronic databases including PubMed and Web of Science. Twelve animal, human post mortem, and human imaging studies were included in this review. Screening, data extraction, and quality assessment were undertaken following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for preferred reporting of systematic reviews. Significant associations were identified between LC changes and cognitive decline. Significant reductions in fiber density, neuronal number, and LC volume were seen to correlate with other pathological degenerative markers. Current evidence indicates an important role of the LC in pathogenesis of AD and suggests its potential in both diagnosis and treatment of AD. This systematic review advances our understanding of the role of the LC in AD by synthesizing available evidence, identifying research gaps, highlighting methodological challenges, and making recommendations for future work.
Alzheimer's disease, locus coeruleus, neuromelanin-sensitive magnetic resonance imaging, noradrenaline, norepinephrine, systematic review
5-22
Chen, Yuqing
ac9f4819-db0f-4305-903e-8eead33d255a
Chen, Teng
b6460d17-215b-48e6-8184-3ccf011c117a
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
7 March 2022
Chen, Yuqing
ac9f4819-db0f-4305-903e-8eead33d255a
Chen, Teng
b6460d17-215b-48e6-8184-3ccf011c117a
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Chen, Yuqing, Chen, Teng and Hou, Ruihua
(2022)
Locus Coeruleus in the pathogenesis of Alzheimer’s Disease: a systematic review.
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 8 (1), , [e12257].
(doi:10.1002/trc2.12257).
Abstract
The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic depletion, evidence indicates extensive LC degeneration as its earliest pathological marker. The current study aimed to systematically evaluate current evidence investigating the role of the LC in the pathogenesis of AD. A systematic search of the literature was performed on electronic databases including PubMed and Web of Science. Twelve animal, human post mortem, and human imaging studies were included in this review. Screening, data extraction, and quality assessment were undertaken following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for preferred reporting of systematic reviews. Significant associations were identified between LC changes and cognitive decline. Significant reductions in fiber density, neuronal number, and LC volume were seen to correlate with other pathological degenerative markers. Current evidence indicates an important role of the LC in pathogenesis of AD and suggests its potential in both diagnosis and treatment of AD. This systematic review advances our understanding of the role of the LC in AD by synthesizing available evidence, identifying research gaps, highlighting methodological challenges, and making recommendations for future work.
Text
A D Transl Res Clin Interv - 2022 - Chen - Locus coeruleus
- Version of Record
More information
Accepted/In Press date: 11 June 2021
e-pub ahead of print date: 31 August 2021
Published date: 7 March 2022
Additional Information:
Funding Information:
Ruihua Hou was awarded a pilot project grant from Alzheimer's Research UK (grant reference: ARUK PPG2016A-6) to conduct a case-control study of the locus coeruleus degeneration in Alzheimer's disease.
Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.
Keywords:
Alzheimer's disease, locus coeruleus, neuromelanin-sensitive magnetic resonance imaging, noradrenaline, norepinephrine, systematic review
Identifiers
Local EPrints ID: 454199
URI: http://eprints.soton.ac.uk/id/eprint/454199
PURE UUID: 65d8a3e0-9c1a-4513-9916-f2aaf4f95292
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Date deposited: 02 Feb 2022 17:45
Last modified: 17 Mar 2024 03:10
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Author:
Yuqing Chen
Author:
Teng Chen
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