The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

Accepted/In Press date: 16 July 2021

e-pub ahead of print date: 2 December 2021

Published date: 1 January 2022

Additional Information: Funding Information: We dedicate this work to the memory of Roger Williams, in following up on his tireless efforts for the Lancet Commission on liver disease in the UK. The opinions expressed and arguments used herein are solely those of the authors and do not necessarily reflect the official views of the Organisation for Economic Co-operation and Development or of its member countries. We thank Christian Kuschel for work on the development of the HCV economic model. We thank Commissioners Angelos Hatzakis and Marina Maevskaya for useful discussions. We thank Neil Guha for helpful input to the primary care sections. We thank Nikolai Pushkarev and Peter Rice for helpful discussions on the recommendations of the Commission. We thank medical illustrator Kari Toverud for graphical assistance in developing figures 4, 15, and 19. We thank Ansgar Lohse for helpful discussions on the role of the European Reference Network for rare liver diseases (RARE-LIVER) and the RARE-LIVER team for relevant administrative support. We thank Vincent Karam and the European Liver Transplant Registry for providing detailed output when requested. We thank Sofia Blomqvist, Margaret Walker, Frauke Degenhardt, and Marit Mæhle Grimsrud for technical assistance. We thank the EASL office for support in organising the physical meetings of the Commission and in administering the many formal and informal surveys performed. We thank Sabine Kleinert for invaluable supervision. We thank Camila Picchio, Adam Palayew, and Danielle Guy for input to early drafts of stigma-related report sections. JVL acknowledges support to ISGlobal from the Spanish Ministry of Science, Innovation and Universities through the Centro de Excelencia Severo Ochoa 2019–2023 Programme (CEX2018-000806-S) and from the Government of Catalonia through the CERCA Programme. This Commission uses data from SHARE Wave 7. The SHARE data collection has been funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193; COMPARE: CIT5-CT-2005-028857; SHARELIFE: CIT4-CT-2006-028812), FP7 (SHARE-PREP: GA N°211909; SHARE-LEAP: GA N°227822; SHARE M4: GA N°261982; DASISH: GA N°283646), and Horizon 2020 (SHARE-DEV3: GA N°676536; SHARE-COHESION: GA N°870628; SERISS: GA N°654221; SSHOC: GA N°823782) and by DG Employment, Social Affairs & Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2; P01_AG005842; P01_AG08291; P30_AG12815; R21_AG025169; Y1-AG-4553-01; IAG_BSR06-11; OGHA_04-064; HHSN271201300071C), and from various national funding sources is gratefully acknowledged. PC acknowledges support by the French National Agency for HIV, hepatitis and emerging infectious diseases research (ANRS / EMERGING INFECTIOUS DISEASES). We thank Yossi Harel-Fisch and Riki Tesler for their help in providing HBSC data and their support in the analysis of these data. We thank Carina Ferreira-Borges and colleagues for approval to reprint the supplementary figure in the appendix (p 32). Funding Information: We dedicate this work to the memory of Roger Williams, in following up on his tireless efforts for the Lancet Commission on liver disease in the UK. The opinions expressed and arguments used herein are solely those of the authors and do not necessarily reflect the official views of the Organisation for Economic Co-operation and Development or of its member countries. We thank Christian Kuschel for work on the development of the HCV economic model. We thank Commissioners Angelos Hatzakis and Marina Maevskaya for useful discussions. We thank Neil Guha for helpful input to the primary care sections. We thank Nikolai Pushkarev and Peter Rice for helpful discussions on the recommendations of the Commission. We thank medical illustrator Kari Toverud for graphical assistance in developing figures 4, 15, and 19. We thank Ansgar Lohse for helpful discussions on the role of the European Reference Network for rare liver diseases (RARE-LIVER) and the RARE-LIVER team for relevant administrative support. We thank Vincent Karam and the European Liver Transplant Registry for providing detailed output when requested. We thank Sofia Blomqvist, Margaret Walker, Frauke Degenhardt, and Marit Mæhle Grimsrud for technical assistance. We thank the EASL office for support in organising the physical meetings of the Commission and in administering the many formal and informal surveys performed. We thank Sabine Kleinert for invaluable supervision. We thank Camila Picchio, Adam Palayew, and Danielle Guy for input to early drafts of stigma-related report sections. JVL acknowledges support to ISGlobal from the Spanish Ministry of Science, Innovation and Universities through the Centro de Excelencia Severo Ochoa 2019–2023 Programme (CEX2018-000806-S) and from the Government of Catalonia through the CERCA Programme. This Commission uses data from SHARE Wave 7. The SHARE data collection has been funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193; COMPARE: CIT5-CT-2005-028857; SHARELIFE: CIT4-CT-2006-028812), FP7 (SHARE-PREP: GA N°211909; SHARE-LEAP: GA N°227822; SHARE M4: GA N°261982; DASISH: GA N°283646), and Horizon 2020 (SHARE-DEV3: GA N°676536; SHARE-COHESION: GA N°870628; SERISS: GA N°654221; SSHOC: GA N°823782) and by DG Employment, Social Affairs & Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the US National Institute on Aging (U01_AG09740-13S2; P01_AG005842; P01_AG08291; P30_AG12815; R21_AG025169; Y1-AG-4553-01; IAG_BSR06-11; OGHA_04-064; HHSN271201300071C), and from various national funding sources is gratefully acknowledged. PC acknowledges support by the French National Agency for HIV, hepatitis and emerging infectious diseases research (ANRS / EMERGING INFECTIOUS DISEASES). We thank Yossi Harel-Fisch and Riki Tesler for their help in providing HBSC data and their support in the analysis of these data. We thank Carina Ferreira-Borges and colleagues for approval to reprint the supplementary figure in the appendix (p 32) . Funding Information: IG received support from Fundacion de Investigacion sanitaria and was cofunded by Instituto Carlos III for the present manuscript; payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences, Intercept, and AbbVie; and support for attending meetings or travel from Intercept and Gilead Sciences. EB received grants or contracts from Gilead Sciences; received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences and Novo Nordisk; and participated on Data Safety Monitoring Boards or advisory boards for Bristol Myers Squibb, Boehringer Ingelheim, Gilead Sciences, Intercept, Inventiva, and Novo Nordisk. MC received grants or contracts and support for attending meetings or travel from the OECD programme of work for public health. RF received grants or contracts from Gilead Sciences, AbbVie, Roche, and Merck Sharp & Dohme; consulting fees from Gilead Sciences, AbbVie, Janssen, and Pfizer; payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences, AbbVie, Merck Sharp & Dohme, and AdamedPG; and support for attending meetings or travel from Gilead Sciences, AbbVie, and Merck Sharp & Dohme. JVL received grants or contracts from AbbVie, Gilead Sciences, Merck Sharp & Dohme; and payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from AbbVie, Gilead Sciences, Intercept, Janssen, and Merck Sharp & Dohme. AL received grants or contracts from the OECD programme of work for public health, which is supported by Ministries of Health, National Governmental Institutions, and intergovernmental organisations, as well as support to present results from OECD analyses to meetings, seminars, and workshops. CL received grants or contracts from the University of Oxford, UK National Centre for Smoking Cessation and Training, and Horizon 2020 of the European Commission; received royalties or licenses from and has patents planned, issued, or pending with Olvos Science (Cretan Iama); received payment for expert testimony from WHO and the European Commission; and participated on Data Safety Monitoring Boards or advisory boards for Merck Sharp & Dohme, Pfizer Hellas, Vianex. MPM received grants or contracts from AbbVie, Eiger BioPharmaceuticals, Bristol Myers Squibb, Dr Falk Pharma, Gilead Sciences, Intercept, Merck Sharp & Dohme, and Roche; received consulting fees from AbbVie, Bristol Myers Squibb, Dr Falk Pharma, Gilead Sciences, Intercept, Merck Sharp & Dohme, Novartis, and Roche; received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from AbbVie, Bristol Myers Squibb, Dr Falk Pharma, Gilead Sciences, Merck Sharp & Dohme, and Roche; received support for attending meetings or travel from AbbVie, Bristol Myers Squibb, Dr Falk Pharma, Gilead Sciences, Merck Sharp & Dohme, and Roche; participated on Data Safety Monitoring Boards or advisory boards for Eiger, Dr Falk Pharma, Gilead Sciences, and Roche; and is Associate Editor for Clinical Gastroenterology and Hepatology. NKM received grants or contracts from Merck Sharp & Dohme and Gilead Sciences. MN received grants or contracts from Gilead Sciences, Merck Sharp & Dohme, AbbVie, and Janssen; and was President of the World Hepatitis Alliance (2018–20). CYP received grants or contracts from Takeda, Pliant, and Gilead Sciences; consulting fees from Pliant and Shire (Takeda); and payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Takeda, Tillotts Pharma, and Pfizer. BSa received grants or contracts from Bristol Myers Squibb and Sirtex Medical; received consulting fees from Adaptimmune, AstraZeneca, Bayer, Bristol Myers Squibb, BTG, Sirtex Medical, TERUMO, H3 Biomedicine, Incyte, Ipsen, Lilly, and Roche; received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Bayer, Bristol Myers Squibb, Sirtex Medical, TERUMO, Incyte, and Ipsen; and participated on Data Safety Monitoring Boards or advisory boards for Adaptimmune, AstraZeneca, Bayer, Bristol Myers Squibb, BTG, Sirtex Medical, TERUMO, H3 Biomedicine, Incyte, Ipsen, Lilly, and Roche. CS received grants or contracts from BiomX and Galapagos; consulting fees from BiomX; and payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Falk Foundation. NSc received grants or contracts from Gilead Sciences. MS-B received grants or contracts from the European Commission. CT received grants or contracts from Merck Sharp & Dohme; and payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences and AbbVie. RB received consulting fees from WHO. HC-P received consulting fees from Orphalan; and payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Orphalan, Novo Nordisk, GENFIT, Promethera Biosciences, and Intercept. GD received consulting fees from Aligos Therapeutics, Roche, Arbutus Biopharma, Gilead Sciences, Shionogi, Antios Therapeutics; received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences; and participated on Data Safety Monitoring Boards or advisory boards for Janssen, Pharmaceuticals, GlaxoSmithKline, and Aligos Therapeutics. THK received consulting fees from Engitix and Intercept; has stock or stock options in Ultimovacs; received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences, Novartis, and AlfaSigma; and is on the board of the Biomedical Alliance in Europe. ES received consulting fees from Albireo, Mirum, and Alexion; received support for attending meetings or travel from Astellas; participated on Data Safety Monitoring Boards or advisory boards for Albireo, Alexion, and Mirum; and received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Albireo. PB received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Kedrion Biopharma, Biotest, and Chiesi Farmaceutici. MB received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences and AbbVie. SJH received payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Gilead Sciences. NF participated on Data Safety Monitoring Boards or advisory boards for Intercept in relation to NAFLD. GM participated on Data Safety Monitoring Boards or advisory boards for Gilead Sciences, Novartis, Pfizer, and AstraZeneca. All other authors declare no competing interests.

Local EPrints ID: 454233

URI: http://eprints.soton.ac.uk/id/eprint/454233

DOI: doi:10.1016/S0140-6736(21)01701-3

ISSN: 0140-6736

PURE UUID: 9ec4d5cd-e3f1-4c3d-b783-825f7b6ebc2a

ORCID for Chris D Byrne: orcid.org/0000-0001-6322-7753

Date deposited: 03 Feb 2022 17:45

Last modified: 17 Mar 2024 02:49