RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

Published date: 17 January 2022

Additional Information: Funding Information: M.H. is funded by a Lise Meitner Max Planck Research Group Leader award (LMA MOZG0001). Part of this work was funded by a Horizon 2020 grant (LSFM4LIFE) and a Wellcome Trust Sir Henry Dale Fellowship from the Wellcome Trust and Royal Society (104151/Z/14/Z) awarded to M.H. G.M. and B.-K.K. were funded by a Marie Curie Initial Training Network (Marie Curie ITN WntsApp 608180). We acknowledge core funding from the MPI-CBG and the Gurdon Institute WT, 092096 and CRUK, C6946/A14492. Also, we would like to acknowledge the Gurdon Institute and Cambridge Stem Cell Institute Animal facilities and the MPI-CBG Imaging and MPI-CBG Image Analysis Facilities; Dr Maike Paramor (Cambridge Stem Cell Institute) and Mr Kay Harnish of the Gurdon Institute genomics facility for assistance with sequencing; Dr Andre Nadler, from MPI-CBG, for constructive discussions; Dr Laura Broutier, Dr Luigi Aloia and Lucia Cordero-Espinoza for experimental help; Sara Seifert for help with hepatocyte isolations; Dr Holger Kramer and Dr Joao Mokochinski (MRC London Institute of Medical Sciences) for access to MS instrumentation; and, additionally, Professor Hans Clevers and Professor Pierre Chambon for sharing the Rnf43-flx/Znrf3-flx and AlbCre-ERT2 mice, respectively. Publisher Copyright: © 2022, The Author(s).

Local EPrints ID: 454237

URI: http://eprints.soton.ac.uk/id/eprint/454237

DOI: doi:10.1038/s41467-021-27923-z

ISSN: 2041-1723

PURE UUID: 0b8d7980-a42c-41e3-b569-5c6b79fc8687

ORCID for Nicole Prior: orcid.org/0000-0003-2856-7052

Date deposited: 03 Feb 2022 17:46

Last modified: 17 Mar 2024 04:02