Increased genetic diversity of Neisseria meningitidis isolates after the introduction of meningococcal serogroup C polysaccharide conjugate vaccines
Increased genetic diversity of Neisseria meningitidis isolates after the introduction of meningococcal serogroup C polysaccharide conjugate vaccines
During the 1990s, the incidence of meningococcal disease was high in the United Kingdom. This was due primarily to an increase in serogroup C disease, particularly that within the ET-37/ST-11 genetic lineage. Serogroup C meningococcal polysaccharide conjugate vaccines were introduced in the United Kingdom in 1999, but the sequence types of meningococci causing disease since that time have not yet been reported. We have used serogrouping and multilocus sequence typing to characterize meningococci from patients with invasive disease over a 4-year period and show that there is a significant increase in genetic diversity but no genetic evidence of capsule switching.
Genetic Variation, Humans, Meningococcal Infections/epidemiology, Meningococcal Vaccines/administration & dosage, Neisseria meningitidis/classification, Polysaccharides/immunology, United Kingdom
4649-53
Diggle, Mathew A
d739c25b-e038-4a9a-850d-2e2fd6ff4a4f
Clarke, Stuart C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
September 2005
Diggle, Mathew A
d739c25b-e038-4a9a-850d-2e2fd6ff4a4f
Clarke, Stuart C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Diggle, Mathew A and Clarke, Stuart C
(2005)
Increased genetic diversity of Neisseria meningitidis isolates after the introduction of meningococcal serogroup C polysaccharide conjugate vaccines.
Journal of Clinical Microbiology, 43 (9), .
(doi:10.1128/JCM.43.9.4649-4653.2005).
Abstract
During the 1990s, the incidence of meningococcal disease was high in the United Kingdom. This was due primarily to an increase in serogroup C disease, particularly that within the ET-37/ST-11 genetic lineage. Serogroup C meningococcal polysaccharide conjugate vaccines were introduced in the United Kingdom in 1999, but the sequence types of meningococci causing disease since that time have not yet been reported. We have used serogrouping and multilocus sequence typing to characterize meningococci from patients with invasive disease over a 4-year period and show that there is a significant increase in genetic diversity but no genetic evidence of capsule switching.
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Published date: September 2005
Keywords:
Genetic Variation, Humans, Meningococcal Infections/epidemiology, Meningococcal Vaccines/administration & dosage, Neisseria meningitidis/classification, Polysaccharides/immunology, United Kingdom
Identifiers
Local EPrints ID: 454308
URI: http://eprints.soton.ac.uk/id/eprint/454308
ISSN: 0095-1137
PURE UUID: c6c3c994-d3cb-49fa-af48-13b6f56c72e8
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Date deposited: 07 Feb 2022 17:37
Last modified: 17 Mar 2024 03:07
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Author:
Mathew A Diggle
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