Serum 25-hydroxy vitamin D and the risk of low muscle mass in young and middle-aged Korean adults
Serum 25-hydroxy vitamin D and the risk of low muscle mass in young and middle-aged Korean adults
Objective: Despite the known benefit of vitamin D in reducing sarcopenia risk in older adults, its effect against muscle loss in the young population is unknown. We aimed to examine the association of serum 25-hydroxy vitamin D [25(OH)D] level and its changes over time with the risk of incident low muscle mass (LMM) in young and middle-aged adults.
Design: This study is a cohort study.
Methods: The study included Korean adults (median age: 36.9 years) without LMM at baseline followed up for a median of 3.9 years (maximum: 7.3 years). LMM was defined as the appendicular skeletal muscle (ASM) mass by body weight (ASM/weight) of 1 s.d. below the sex-specific mean for the young reference group. Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95% CIs.
Results: Of the 192,908 individuals without LMM at baseline, 19,526 developed LMM. After adjusting for potential confounders, the multivariable-adjusted HRs (95% CIs) for incident LMM comparing 25(OH)D levels of 25-<50, 50-<75, and ≥75 nmol/L to 25(OH)D <25 nmol/L were 0.93 (0.90-0.97), 0.85 (0.81-0.89), and 0.77 (0.71-0.83), respectively. The inverse association of 25(OH)D with incident LMM was consistently observed in young (aged <40 years) and older individuals (aged ≥40 years). Individuals with increased 25(OH)D levels (<50-≥50 nmol/L) or persistently adequate 25(OH)D levels (≥50 nmol/L) between baseline and follow-up visit had a lower risk of incident LMM than those with persistently low 25(OH)D levels.
Conclusions: Maintaining sufficient serum 25(OH)D could prevent unfavourable changes in muscle mass in both young and middle-aged Korean adults.
477-487
Kim, Yejin
2e048ae0-42a5-4dbd-9c80-5e1ff5b4f3ed
Chang, Yoosoo
f35fa2f5-f6c0-4338-8dac-ce561e53b817
Ryu, Seungho
b05f8cc6-f602-4943-8d3a-c88d75ff5b62
Cho, In Young
ab8038c0-69d2-45ee-bb78-02deaf8323d3
Kwon, Min-Jung
7ce98e48-2aa6-4e65-81a3-557551014ac1
Wild, Sarah H
793127ee-3b86-41c3-80b6-bbdeeb45872b
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
April 2022
Kim, Yejin
2e048ae0-42a5-4dbd-9c80-5e1ff5b4f3ed
Chang, Yoosoo
f35fa2f5-f6c0-4338-8dac-ce561e53b817
Ryu, Seungho
b05f8cc6-f602-4943-8d3a-c88d75ff5b62
Cho, In Young
ab8038c0-69d2-45ee-bb78-02deaf8323d3
Kwon, Min-Jung
7ce98e48-2aa6-4e65-81a3-557551014ac1
Wild, Sarah H
793127ee-3b86-41c3-80b6-bbdeeb45872b
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Kim, Yejin, Chang, Yoosoo, Ryu, Seungho, Cho, In Young, Kwon, Min-Jung, Wild, Sarah H and Byrne, Christopher
(2022)
Serum 25-hydroxy vitamin D and the risk of low muscle mass in young and middle-aged Korean adults.
European journal of endocrinology, 186 (4), .
(doi:10.1530/EJE-21-1229).
Abstract
Objective: Despite the known benefit of vitamin D in reducing sarcopenia risk in older adults, its effect against muscle loss in the young population is unknown. We aimed to examine the association of serum 25-hydroxy vitamin D [25(OH)D] level and its changes over time with the risk of incident low muscle mass (LMM) in young and middle-aged adults.
Design: This study is a cohort study.
Methods: The study included Korean adults (median age: 36.9 years) without LMM at baseline followed up for a median of 3.9 years (maximum: 7.3 years). LMM was defined as the appendicular skeletal muscle (ASM) mass by body weight (ASM/weight) of 1 s.d. below the sex-specific mean for the young reference group. Cox proportional hazard models were used to estimate hazard ratios (HRs) with 95% CIs.
Results: Of the 192,908 individuals without LMM at baseline, 19,526 developed LMM. After adjusting for potential confounders, the multivariable-adjusted HRs (95% CIs) for incident LMM comparing 25(OH)D levels of 25-<50, 50-<75, and ≥75 nmol/L to 25(OH)D <25 nmol/L were 0.93 (0.90-0.97), 0.85 (0.81-0.89), and 0.77 (0.71-0.83), respectively. The inverse association of 25(OH)D with incident LMM was consistently observed in young (aged <40 years) and older individuals (aged ≥40 years). Individuals with increased 25(OH)D levels (<50-≥50 nmol/L) or persistently adequate 25(OH)D levels (≥50 nmol/L) between baseline and follow-up visit had a lower risk of incident LMM than those with persistently low 25(OH)D levels.
Conclusions: Maintaining sufficient serum 25(OH)D could prevent unfavourable changes in muscle mass in both young and middle-aged Korean adults.
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e-pub ahead of print date: 1 February 2022
Published date: April 2022
Additional Information:
Funding Information:
This work was supported by SKKU Excellence in Research Award Research Fund, Sungkyunkwan University, 2020. C D B is supported in part by the Southampton NIHR Biomedical Research Centre (IS-BRC-20004).
Publisher Copyright:
© 2022 The authors.
Identifiers
Local EPrints ID: 454493
URI: http://eprints.soton.ac.uk/id/eprint/454493
ISSN: 0804-4643
PURE UUID: 9cdf604b-eb36-4c11-a125-b6c8ee7dc624
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Date deposited: 14 Feb 2022 17:31
Last modified: 17 Mar 2024 02:49
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Contributors
Author:
Yejin Kim
Author:
Yoosoo Chang
Author:
Seungho Ryu
Author:
In Young Cho
Author:
Min-Jung Kwon
Author:
Sarah H Wild
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