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Bronchoalveolar lavage MMP-9 and TIMP-1 in preschool wheezers and their relationship to persistent wheeze

Erlewyn-Lajeunesse, Michel D.S., Hunt, Linda P., Pohunek, Petr, Dobson, Sarah J., Kochhar, Puja, Warner, Jane A. and Warner, John O. (2008) Bronchoalveolar lavage MMP-9 and TIMP-1 in preschool wheezers and their relationship to persistent wheeze Pediatric Research, 64, (2), pp. 194-199. (doi:10.1203/PDR.0b013e318175dd2d). (PMID:18391843).

Record type: Article


AB Atopic preschool children are more likely to develop persistent wheezing, which could be a consequence of early airway remodeling. Protease-antiprotease balance between MMP-9 and its cognate inhibitor TIMP-1 may be involved in this process. Our hypothesis was that atopic wheezing preschool children would have an imbalance of MMP-9 to TIMP-1 in bronchoalveolar lavage (BAL). BAL from 52 preschool wheezers was compared with 14 controls without wheeze. A subgroup completed an International Study of Asthma and Allergy in Childhood symptom questionnaire 2 y later. Molar ratios of MMP-9/TIMP-1 were higher in wheezy children (p < 0.001; median 4.0%, range 0-8.7) than controls (0.6%, 0-1.8), and showed an excess of TIMP-1 in the airway. BAL TIMP-1 was raised in children with persistent wheezing (p = 0.028; 34.4 ng/mL, 9.1-93.1 compared with 10.6 ng/mL 6.1-18.6), as was serum levels of intercellular adhesion molecule-1 (p = 0.027). The absolute concentration of TIMP-1 in the airway, rather than its molar ratio with MMP-9, was associated with persistent wheezing. The processes involved with airway remodeling are complex but excess TIMP-1 may impede matrix protein turnover and thereby contribute to persistent changes in airway structure and wheezing

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Published date: August 2008


Local EPrints ID: 45460
ISSN: 0031-3998
PURE UUID: 708e48be-35a5-4b9b-97b9-3ffb41495261

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Date deposited: 18 Feb 2010
Last modified: 17 Jul 2017 15:12

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Author: Michel D.S. Erlewyn-Lajeunesse
Author: Linda P. Hunt
Author: Petr Pohunek
Author: Sarah J. Dobson
Author: Puja Kochhar
Author: Jane A. Warner
Author: John O. Warner

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