An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field
Cilia are microtubule-based organelles with important functions in motility and sensation. They contribute to a broad spectrum of developmental disorders called ciliopathies, and have recently been linked to common conditions such as cancers and congenital heart disease. There has been increasing interest in the biology of cilia and their contribution to disease over the past two decades. As a result, in 2013 we published a ‘Gold Standard’ list of genes confirmed to be associated with cilia. This was published as part of the SYSCILIA consortium systems biology study dissecting the contribution of cilia to human health and disease, and was named the Syscilia Gold Standard (SCGS). Since this publication, interest in cilia and understanding of their functions has continued to grow, and we now present an updated SCGS version 2. This includes an additional 383 genes, more than doubling the size of SCGSv1. We use this dataset to conduct a review of advances in understanding of cilia biology 2013-2021, and perspectives on the future of cilia research. We hope that this continues to be a useful resource for the cilia community.
Villa Vasquez, Suly, Saray
eb8fd041-ed3d-4f90-9094-12ab7c83163b
van Dam, John
3d6189d9-1237-4b32-8812-ef9d3e6224a5
Wheway, Gabrielle
2e547e5d-b921-4243-a071-2208fd4cc090
29 November 2021
Villa Vasquez, Suly, Saray
eb8fd041-ed3d-4f90-9094-12ab7c83163b
van Dam, John
3d6189d9-1237-4b32-8812-ef9d3e6224a5
Wheway, Gabrielle
2e547e5d-b921-4243-a071-2208fd4cc090
Villa Vasquez, Suly, Saray, van Dam, John and Wheway, Gabrielle
(2021)
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field.
Molecular Biology of the Cell, 32 (22).
(doi:10.1091/mbc.e21-05-0226).
Abstract
Cilia are microtubule-based organelles with important functions in motility and sensation. They contribute to a broad spectrum of developmental disorders called ciliopathies, and have recently been linked to common conditions such as cancers and congenital heart disease. There has been increasing interest in the biology of cilia and their contribution to disease over the past two decades. As a result, in 2013 we published a ‘Gold Standard’ list of genes confirmed to be associated with cilia. This was published as part of the SYSCILIA consortium systems biology study dissecting the contribution of cilia to human health and disease, and was named the Syscilia Gold Standard (SCGS). Since this publication, interest in cilia and understanding of their functions has continued to grow, and we now present an updated SCGS version 2. This includes an additional 383 genes, more than doubling the size of SCGSv1. We use this dataset to conduct a review of advances in understanding of cilia biology 2013-2021, and perspectives on the future of cilia research. We hope that this continues to be a useful resource for the cilia community.
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SYSCILIA_v2
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SCGSv2_supplementary material
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Submitted date: 4 May 2021
Accepted/In Press date: 28 September 2021
Published date: 29 November 2021
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Local EPrints ID: 454842
URI: http://eprints.soton.ac.uk/id/eprint/454842
ISSN: 1059-1524
PURE UUID: 3fa67f6c-d7ff-423c-ae2e-e494080c0435
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Date deposited: 24 Feb 2022 21:57
Last modified: 16 Apr 2024 01:59
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Author:
Suly, Saray Villa Vasquez
Author:
John van Dam
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