Stulz, Eugen (2021) Bio-inspired functional DNA architectures. In, Govindaraju, Thimmaiah and Ariga, Katsuhiko (eds.) Molecular Architectonics and Nanoarchitectonics. Springer, pp. 259-280. (doi:10.1007/978-981-16-4189-3_11).
Abstract
DNA is well-known as bearer of the genetic code. Since its structure elucidation around seven decades ago by Watson, Crick, Wilkins and Franklin [1–3], much has been learnt about its detailed structure, function and genetic coding. In the field of DNA chemistry, solid-phase synthesis (SPS) of DNA certainly is one of the most influential developments of the last century [4–6] as it allows to synthesise DNA in any desired sequence and in lengths of up to hundreds of bases in the very best case. This has advanced the field of DNA research substantially. In addition, classic organic synthesis has allowed the introduction of a very large diversity of modifications in the DNA in a sequence-specific manner, which have initially been targeted at altering the biological function of DNA.
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