The effects of lisdexamfetamine dimesylate on eating behaviour and homeostatic, reward and cognitive processes in women with binge-eating symptoms: an experimental medicine study
The effects of lisdexamfetamine dimesylate on eating behaviour and homeostatic, reward and cognitive processes in women with binge-eating symptoms: an experimental medicine study
Lisdexamfetamine dimesylate (LDX) is the only drug currently approved by the FDA for the treatment of Binge-Eating Disorder (BED), but little is known about the behavioural mechanisms that underpin the efficacy of LDX in treating BED. We examined the behavioural and neural effects of an acute dose of LDX (50 mg) in 22 women with binge-eating symptomatology using a randomised, crossover, double-blind, placebo-controlled experimental medicine design. LDX reduced self-reported appetite ratings and intake of both a pasta meal and a palatable cookie snack. LDX also decreased the eating rate of pasta but not of cookies and reduced self-reported liking ratings for pasta at the end of the meal. When viewing food pictures during an fMRI scan, LDX reduced activity bilaterally in the thalamus. LDX enhanced sustained attention and reduced impulsive responding in a continuous performance task but had no effect on emotional bias or working memory. These results suggest the observed effects of LDX on food intake (and by implication the efficacy of LDX in treating BED) may be related to the actions of the drug to enhance satiety, reduce food-related reward responding when full and/or increase cognitive control. Novel pharmacotherapies for BED might be most effective if they have a broad spectrum of effects on appetite, reward and cognition.
Attention Deficit Disorder with Hyperactivity/drug therapy, Binge-Eating Disorder/drug therapy, Biomedical Research, Central Nervous System Stimulants/therapeutic use, Cognition, Dextroamphetamine, Double-Blind Method, Feeding Behavior, Female, Humans, Lisdexamfetamine Dimesylate, Reward, Treatment Outcome
9
Schneider, Elizabeth
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Martin, Elizabeth
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Rotshtein, Pia
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Qureshi, Kasim L.
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Chamberlain, Samuel R.
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Spetter, Maartje S.
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Dourish, Colin T.
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Higgs, Suzanne
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11 January 2022
Schneider, Elizabeth
8bbedf36-b0a9-4c5f-85bd-d76a55eefedf
Martin, Elizabeth
cc689e18-49fa-45b5-b744-9fbef55b697e
Rotshtein, Pia
082ffd65-5751-4332-b765-30b4db2dba18
Qureshi, Kasim L.
c6dbccc6-c3fa-4dc5-9898-6b5f65bad68e
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f
Spetter, Maartje S.
7200619a-b72c-406b-9b90-36d907597ce2
Dourish, Colin T.
1f6d0f3b-1e4e-4829-b17a-9b0dd2e72cc5
Higgs, Suzanne
9cde657a-a70a-42a9-b4aa-c8e0b23c7237
Schneider, Elizabeth, Martin, Elizabeth, Rotshtein, Pia, Qureshi, Kasim L., Chamberlain, Samuel R., Spetter, Maartje S., Dourish, Colin T. and Higgs, Suzanne
(2022)
The effects of lisdexamfetamine dimesylate on eating behaviour and homeostatic, reward and cognitive processes in women with binge-eating symptoms: an experimental medicine study.
Translational Psychiatry, 12 (1), , [9].
(doi:10.1038/s41398-021-01770-4).
Abstract
Lisdexamfetamine dimesylate (LDX) is the only drug currently approved by the FDA for the treatment of Binge-Eating Disorder (BED), but little is known about the behavioural mechanisms that underpin the efficacy of LDX in treating BED. We examined the behavioural and neural effects of an acute dose of LDX (50 mg) in 22 women with binge-eating symptomatology using a randomised, crossover, double-blind, placebo-controlled experimental medicine design. LDX reduced self-reported appetite ratings and intake of both a pasta meal and a palatable cookie snack. LDX also decreased the eating rate of pasta but not of cookies and reduced self-reported liking ratings for pasta at the end of the meal. When viewing food pictures during an fMRI scan, LDX reduced activity bilaterally in the thalamus. LDX enhanced sustained attention and reduced impulsive responding in a continuous performance task but had no effect on emotional bias or working memory. These results suggest the observed effects of LDX on food intake (and by implication the efficacy of LDX in treating BED) may be related to the actions of the drug to enhance satiety, reduce food-related reward responding when full and/or increase cognitive control. Novel pharmacotherapies for BED might be most effective if they have a broad spectrum of effects on appetite, reward and cognition.
More information
e-pub ahead of print date: 11 January 2022
Published date: 11 January 2022
Additional Information:
Funding Information:
Role of Funding Source. Funding for this work was provided by BBSRC Grant UK to SH grant number: BB/N008847/1. The BBSRC had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Colin T Dourish is a Director and Co-Owner of P1vital Limited and a Director and Co-Owner of P1vital Products Limited. Prof. Chamberlain’s role in this study was funded by a Wellcome Trust Clinical Fellowship (110049/Z/15/Z & 110049/Z/15/A). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Prof. Chamberlain receives honoraria from Elsevier for editorial work. He previously consulted for Promentis.
Keywords:
Attention Deficit Disorder with Hyperactivity/drug therapy, Binge-Eating Disorder/drug therapy, Biomedical Research, Central Nervous System Stimulants/therapeutic use, Cognition, Dextroamphetamine, Double-Blind Method, Feeding Behavior, Female, Humans, Lisdexamfetamine Dimesylate, Reward, Treatment Outcome
Identifiers
Local EPrints ID: 455111
URI: http://eprints.soton.ac.uk/id/eprint/455111
PURE UUID: 363d9668-83dc-47de-913d-8b32959af26d
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Date deposited: 09 Mar 2022 17:51
Last modified: 18 Mar 2024 03:58
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Contributors
Author:
Elizabeth Schneider
Author:
Elizabeth Martin
Author:
Pia Rotshtein
Author:
Kasim L. Qureshi
Author:
Samuel R. Chamberlain
Author:
Maartje S. Spetter
Author:
Colin T. Dourish
Author:
Suzanne Higgs
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