Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort
Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort
A high (20%) prevalence of glucose intolerance at 18-years was seen in women from the Pune Maternal Nutrition Study (PMNS) birth cohort. Here, we provide preliminary longitudinal analyses of circulating microRNAs in normal glucose tolerant (NGT@18y, N=10) and glucose intolerant (N=8) women (ADA criteria) at 6-, 12- and 17-years of their age using discovery analysis (OpenArray™ platform). Machine-learning workflows involving Lasso with bootstrapping/leave-one-out cross-validation (LOOCV) identified microRNAs associated with glucose intolerance at 18-years of age. Several microRNAs, including miR-212-3p, miR-30e-3p and miR-638, stratified glucose-intolerant women from NGT at childhood. Our results suggest that circulating microRNAs in childhood could predict pre-diabetes at 18-years of age. Validation of these findings in males and remaining participants from the PMNS birth cohort will provide a unique opportunity to study novel epigenetic mechanisms in the life-course progression of glucose intolerance and enhance current clinical risk prediction of pre-diabetes and progression to type 2 diabetes.
Adolescent, Biomarkers, Child, Preschool, Circulating MicroRNA/genetics, Diabetes Mellitus, Type 2/epidemiology, Female, Glucose, Glucose Intolerance/diagnosis, Humans, India, Male, MicroRNAs/genetics, Prediabetic State/diagnosis
806-811
Joglekar, M V
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Kunte, Pooja S.
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Wong, Wilson K M
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Bhat, D.S.
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Satoor, Sarang N.
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Patil, Rohan R.
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Karandikar, Mahesh S.
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Fall, Caroline
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Yajnik, Chittaranjan S.
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Hardikar, Anandwardhan A.
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December 2022
Joglekar, M V
60220493-5e85-4c12-9f09-8b39aa19e9fc
Kunte, Pooja S.
b58c5ce9-6ddd-4a9e-a34d-13658b87dc39
Wong, Wilson K M
9afcd5b3-dff0-4867-8221-a2c9d3a5351e
Bhat, D.S.
75412cda-4b68-4286-82e2-8f9ea39fd842
Satoor, Sarang N.
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Patil, Rohan R.
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Karandikar, Mahesh S.
76aef419-343d-439d-a580-ca8111baf6c8
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Yajnik, Chittaranjan S.
f5777038-bba7-49bd-80b9-be4e586eecf4
Hardikar, Anandwardhan A.
19908813-44a1-4be0-885f-879548abb45c
Joglekar, M V, Kunte, Pooja S., Wong, Wilson K M, Bhat, D.S., Satoor, Sarang N., Patil, Rohan R., Karandikar, Mahesh S., Fall, Caroline, Yajnik, Chittaranjan S. and Hardikar, Anandwardhan A.
(2022)
Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort.
Journal of Developmental Origins of Health and Disease, 13 (6), .
(doi:10.1101/2021.11.24.21266835).
Abstract
A high (20%) prevalence of glucose intolerance at 18-years was seen in women from the Pune Maternal Nutrition Study (PMNS) birth cohort. Here, we provide preliminary longitudinal analyses of circulating microRNAs in normal glucose tolerant (NGT@18y, N=10) and glucose intolerant (N=8) women (ADA criteria) at 6-, 12- and 17-years of their age using discovery analysis (OpenArray™ platform). Machine-learning workflows involving Lasso with bootstrapping/leave-one-out cross-validation (LOOCV) identified microRNAs associated with glucose intolerance at 18-years of age. Several microRNAs, including miR-212-3p, miR-30e-3p and miR-638, stratified glucose-intolerant women from NGT at childhood. Our results suggest that circulating microRNAs in childhood could predict pre-diabetes at 18-years of age. Validation of these findings in males and remaining participants from the PMNS birth cohort will provide a unique opportunity to study novel epigenetic mechanisms in the life-course progression of glucose intolerance and enhance current clinical risk prediction of pre-diabetes and progression to type 2 diabetes.
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2021.11.24.21266835v1.full
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Joglekar final clean accepted version 14 02 2022
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Accepted/In Press date: 26 November 2021
e-pub ahead of print date: 22 April 2022
Published date: December 2022
Additional Information:
© The Author(s), 2022. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease
Keywords:
Adolescent, Biomarkers, Child, Preschool, Circulating MicroRNA/genetics, Diabetes Mellitus, Type 2/epidemiology, Female, Glucose, Glucose Intolerance/diagnosis, Humans, India, Male, MicroRNAs/genetics, Prediabetic State/diagnosis
Identifiers
Local EPrints ID: 455121
URI: http://eprints.soton.ac.uk/id/eprint/455121
ISSN: 2040-1744
PURE UUID: ca8f98ab-7944-4857-acea-7ab172ee76b6
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Date deposited: 10 Mar 2022 17:31
Last modified: 17 Mar 2024 07:09
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Contributors
Author:
M V Joglekar
Author:
Pooja S. Kunte
Author:
Wilson K M Wong
Author:
D.S. Bhat
Author:
Sarang N. Satoor
Author:
Rohan R. Patil
Author:
Mahesh S. Karandikar
Author:
Chittaranjan S. Yajnik
Author:
Anandwardhan A. Hardikar
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