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Maternal weight and gestational diabetes impacts on child health

Maternal weight and gestational diabetes impacts on child health
Maternal weight and gestational diabetes impacts on child health
Purpose of review
To review recent evidence linking maternal body mass index and gestational diabetes mellitus (GDM) with offspring health outcomes.

Recent findings
It is now established that the rising prevalences of maternal obesity and GDM are both making substantial contributions to the growing burden of childhood obesity and associated disorders. Strengthening evidence also links maternal obesity with increased offspring risks of cardiovascular disease, nonalcoholic fatty liver disease, lower respiratory tract infections during infancy, wheezing illnesses, asthma and attention deficit hyperactivity disorder during childhood, and with higher risks of psychiatric disorders and colorectal cancer in adulthood. GDM has been associated with increased offspring risks of cardiovascular disease, childhood wheeze/asthma (but not allergic sensitization), and with high refractive error, attention deficit hyperactivity and psychiatric disorders from childhood onwards.

Summary
The long-term consequences of maternal obesity and GDM for the offspring in childhood and later adult life present major challenges for public health across the life course and for future generations. Tackling these challenges requires a systems-based approach to support achieving a healthy weight in young people prior to conception, alongside new insights into population based preventive measures against gestational diabetes.
1363-1950
203-208
Dalrymple, Kathryn V.
8ef94198-4e90-44a9-b77d-19d35d013cde
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Dalrymple, Kathryn V.
8ef94198-4e90-44a9-b77d-19d35d013cde
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

Dalrymple, Kathryn V., El-Heis, Sarah and Godfrey, Keith (2022) Maternal weight and gestational diabetes impacts on child health. Current Opinion in Clinical Nutrition and Metabolic Care, 25 (3), 203-208. (doi:10.1097/MCO.0000000000000826).

Record type: Review

Abstract

Purpose of review
To review recent evidence linking maternal body mass index and gestational diabetes mellitus (GDM) with offspring health outcomes.

Recent findings
It is now established that the rising prevalences of maternal obesity and GDM are both making substantial contributions to the growing burden of childhood obesity and associated disorders. Strengthening evidence also links maternal obesity with increased offspring risks of cardiovascular disease, nonalcoholic fatty liver disease, lower respiratory tract infections during infancy, wheezing illnesses, asthma and attention deficit hyperactivity disorder during childhood, and with higher risks of psychiatric disorders and colorectal cancer in adulthood. GDM has been associated with increased offspring risks of cardiovascular disease, childhood wheeze/asthma (but not allergic sensitization), and with high refractive error, attention deficit hyperactivity and psychiatric disorders from childhood onwards.

Summary
The long-term consequences of maternal obesity and GDM for the offspring in childhood and later adult life present major challenges for public health across the life course and for future generations. Tackling these challenges requires a systems-based approach to support achieving a healthy weight in young people prior to conception, alongside new insights into population based preventive measures against gestational diabetes.

Text
Current Opinion CNMC - Dalrymple El-Heis Godfrey REVISEDa - Accepted Manuscript
Restricted to Repository staff only until 15 February 2023.
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More information

Accepted/In Press date: 15 February 2022
Published date: 1 May 2022
Additional Information: Financial support and sponsorship K.M.G. is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (IS- BRC-1215-20004)), the European Union (Erasmusþ Programme ImpENSA 598488-EPP-1-2018-1-DE- EPPKA2-CBHE-JP), British Heart Foundation (RG/15/ 17/3174, SP/F/21/150013) and the US National Insti- tute On Aging of the National Institutes of Health (Award No. U24AG047867). S.E.H. is supported by the National Institute for Health Research (NIHR Clini- cal Lecturer award). K.V.D. is funded by the UK Medical Research Council (grant number: MR/V005839/1).

Identifiers

Local EPrints ID: 455158
URI: http://eprints.soton.ac.uk/id/eprint/455158
ISSN: 1363-1950
PURE UUID: 3f66a9be-b999-451a-a5b7-66e3924971d1
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 10 Mar 2022 20:13
Last modified: 13 Sep 2022 01:34

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Contributors

Author: Kathryn V. Dalrymple
Author: Sarah El-Heis
Author: Keith Godfrey ORCID iD

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