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A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise

A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise
A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise

Respiratory rate (RR) is a marker of critical illness, but during hospital care, RR is often inaccurately measured. The capaciflector is a novel sensor that is small, inexpensive, and flexible, thus it has the potential to provide a single-use, real-time RR monitoring device. We evaluated the accuracy of continuous RR measurements by capaciflector hardware both at rest and during exercise. Continuous RR measurements were made with capaciflectors at four chest locations. In healthy subjects (n = 20), RR was compared with strain gauge chest belt recordings during timed breathing and two different body positions at rest. In patients undertaking routine cardiopulmonary exercise testing (CPET, n = 50), RR was compared with pneumotachometer recordings. Comparative RR measurement bias and limits of agreement were calculated and presented in Bland–Altman plots. The capaciflector was shown to provide continuous RR measurements with a bias less than 1 breath per minute (BPM) across four chest locations. Accuracy and continuity of monitoring were upheld even during vigorous CPET exercise, often with narrower limits of agreement than those reported for comparable technologies. We provide a unique clinical demonstration of the capaciflector as an accurate breathing monitor, which may have the potential to become a simple and affordable medical device. Clinical trial number: NCT03832205 https://clinicaltrials.gov/ct2/show/NCT03832205registered February 6th, 2019.

Capaciflector, Critical care, Perioperative medicine, Respiratory monitoring, Respiratory rate, Sensor
1387-1307
1535-1546
Hayward, Nick
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Shaban, Mahdi
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Badger, James
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Jones, Isobel
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Wei, Yang
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Spencer, Daniel
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Isichei, Stefania
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Knight, Martin
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Otto, James
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Rayat, Gurinder
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Levett, Denny
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Grocott, Michael
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Akerman, Harry
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White, Neil
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Hayward, Nick
eb6397b5-fa87-4f00-846c-40c67607b7bb
Shaban, Mahdi
55642abf-481a-47e0-93d8-d4c33626ff16
Badger, James
1ab773a5-624b-48a2-8e66-70fa01253b63
Jones, Isobel
1422885f-9819-47af-b617-f005aa856773
Wei, Yang
753cffbb-1cf7-4d81-822c-2be0fb402a58
Spencer, Daniel
4affe9f6-353a-4507-8066-0180b8dc9eaf
Isichei, Stefania
f422e0f4-0b1e-4c95-951a-a513f8ec95e1
Knight, Martin
a3707416-0369-4878-959a-02b09641dd3e
Otto, James
5675a532-7adc-449b-b9fe-f555b870e694
Rayat, Gurinder
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Levett, Denny
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Grocott, Michael
1e87b741-513e-4a22-be13-0f7bb344e8c2
Akerman, Harry
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White, Neil
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Hayward, Nick, Shaban, Mahdi, Badger, James, Jones, Isobel, Wei, Yang, Spencer, Daniel, Isichei, Stefania, Knight, Martin, Otto, James, Rayat, Gurinder, Levett, Denny, Grocott, Michael, Akerman, Harry and White, Neil (2022) A capaciflector provides continuous and accurate respiratory rate monitoring for patients at rest and during exercise. Journal of Clinical Monitoring and Computing, 36 (5), 1535-1546. (doi:10.1007/s10877-021-00798-7).

Record type: Article

Abstract

Respiratory rate (RR) is a marker of critical illness, but during hospital care, RR is often inaccurately measured. The capaciflector is a novel sensor that is small, inexpensive, and flexible, thus it has the potential to provide a single-use, real-time RR monitoring device. We evaluated the accuracy of continuous RR measurements by capaciflector hardware both at rest and during exercise. Continuous RR measurements were made with capaciflectors at four chest locations. In healthy subjects (n = 20), RR was compared with strain gauge chest belt recordings during timed breathing and two different body positions at rest. In patients undertaking routine cardiopulmonary exercise testing (CPET, n = 50), RR was compared with pneumotachometer recordings. Comparative RR measurement bias and limits of agreement were calculated and presented in Bland–Altman plots. The capaciflector was shown to provide continuous RR measurements with a bias less than 1 breath per minute (BPM) across four chest locations. Accuracy and continuity of monitoring were upheld even during vigorous CPET exercise, often with narrower limits of agreement than those reported for comparable technologies. We provide a unique clinical demonstration of the capaciflector as an accurate breathing monitor, which may have the potential to become a simple and affordable medical device. Clinical trial number: NCT03832205 https://clinicaltrials.gov/ct2/show/NCT03832205registered February 6th, 2019.

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Accepted/In Press date: 23 December 2021
e-pub ahead of print date: 18 January 2022
Published date: October 2022
Additional Information: Funding Information: NH is a part-time advisor to Klinik Healthcare Solutions, UK. MG is vice-president of CPX International. He also serves on the medical advisor board of Sphere Medical Ltd and the board of EBPOM Community Interest Company, Medinspire Ltd and Oxygen Control Systems Ltd. He has received honoraria for speaking for and/or travel expenses from BOC Medical (Linde Group), Edwards Lifesciences and Cortex GmBH and unrestricted research support from Sphere Medical Ltd and Pharmacosmos Ltd. He leads the Fit-4-Surgery research collaboration and the Xtreme Everest oxygen research consortium, which has received unrestricted research grant funding from BOC Medical (Linde Group), Deltex Medical and Smiths Medical. MG was funded in part from the British Oxygen Company Chair of the Royal College of Anaesthetists awarded by the National Institute of Academic Anaesthesia. All funding was unrestricted. The funders had no role in study design, data collection and analysis, decision to publish or the preparation of the manuscript. This work was conducted within the Anaesthesia and Critical Care Research Unit, University Hospital Southampton and the School of Electronics and Computer Science, University of Southampton, as a primary research collaboration. Funding Information: NH was funded by a UK National Institute for Health Research (NIHR) Academic Clinical Fellowship. MS, DS, YW and NW were funded by the University of Southampton. JMO, DL and MG work within the University of Southampton NIHR Respiratory Biomedical Research Unit, which received a portion of funding from the UK Department of Health Research Biomedical Research Units funding scheme. All funding was unrestricted. Funding Information: We are grateful for the Departmental research support provided by both the University of Southampton and University Hospital Southampton. We thank all patients, volunteers, and clinical staff for their generosity throughout the conduct of our research. Publisher Copyright: © 2022, The Author(s).
Keywords: Capaciflector, Critical care, Perioperative medicine, Respiratory monitoring, Respiratory rate, Sensor

Identifiers

Local EPrints ID: 455161
URI: http://eprints.soton.ac.uk/id/eprint/455161
ISSN: 1387-1307
PURE UUID: fdd424f0-fbf7-48af-8374-c5119c08e1ff
ORCID for Mahdi Shaban: ORCID iD orcid.org/0000-0002-7219-3708
ORCID for Michael Grocott: ORCID iD orcid.org/0000-0002-9484-7581
ORCID for Neil White: ORCID iD orcid.org/0000-0003-1532-6452

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Date deposited: 10 Mar 2022 20:16
Last modified: 17 Mar 2024 03:17

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Contributors

Author: Nick Hayward
Author: Mahdi Shaban ORCID iD
Author: James Badger
Author: Isobel Jones
Author: Yang Wei
Author: Daniel Spencer
Author: Stefania Isichei
Author: Martin Knight
Author: James Otto
Author: Gurinder Rayat
Author: Denny Levett
Author: Michael Grocott ORCID iD
Author: Harry Akerman
Author: Neil White ORCID iD

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