Sputum cysteinyl‐leukotriene levels correlate with the severity of pulmonary disease in children with cystic fibrosis

Spencer, David A., Sampson, A. P., Green, C. P., Costello, J. F., Piper, P. J. and Price, John F. (1992) Sputum cysteinyl‐leukotriene levels correlate with the severity of pulmonary disease in children with cystic fibrosis. Pediatric Pulmonology, 12 (2), 90-94. (doi:10.1002/ppul.1950120206).

Abstract

Sputum samples from 13 children with cystic fibrosis (CF) were analyzed for leukotrienes (LTs) LTB₄, LTC₄, LTD₄, and LTE₄. Distribution of LTB₄ appeared to be normal, and of cysteinyl‐LTs log normal. Total cysteinyl‐LT levels, of which on average 75% was LTE₄, were nearly 10 times higher than in earlier studies. Log LTE₄ and total cysteinyl‐LT levels correlated with the overall severity of pulmonary disease assessed by Chrispin—Norman chest radiograph score (Log LTE₄: r = 0.701, r² = 49.1%, P = 0.008. Log total cysteinyl‐LTs: r = 0.715, r² = 51.1%, P = 0.006). There was no apparent relationship between LTB₄ levels and Chrispin—Norman chest radiograph score, nor between the level of any of the LTs and age or organism cultured from sputum. These findings suggest that the cysteinyl‐LTs may be involved in the pathophysiology of pulmonary disease in CF. Pediatr pulmonol.1992; 12:90–94.

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Contributors

Author: A. P. Sampson

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