Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel
Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel
Taxanes are one of the most potent and broadest spectrum chemotherapeutics used clinically, but also induce significant side effects. Different strategies have been developed to produce a safer taxane formulation. Development of polysaccharide drug conjugates has increased in the recent years because of the demonstrated biocompatibility, biodegradability, safety, and low cost of the biopolymers. This review focuses on polysaccharide-taxane conjugates and provides an overview on various conjugation strategies and their effect on the efficacy. Detailed analyses on the designing factors of an effective polysaccharide-drug conjugate are provided with a discussion on the future direction of this field.
349-368
Roy, Aniruddha
173c3ff0-7e0e-4633-926a-30e1a9c0578a
Bhattacharyya, Mousumi
ed36a4ed-ce5e-43fd-88b4-b3b003e9efae
Ernsting, Mark J.
9e64eeae-7374-44df-a9cd-5e1b26c94e20
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
2014
Roy, Aniruddha
173c3ff0-7e0e-4633-926a-30e1a9c0578a
Bhattacharyya, Mousumi
ed36a4ed-ce5e-43fd-88b4-b3b003e9efae
Ernsting, Mark J.
9e64eeae-7374-44df-a9cd-5e1b26c94e20
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
Roy, Aniruddha, Bhattacharyya, Mousumi, Ernsting, Mark J., May, Jonathan P. and Li, Shyh Dar
(2014)
Recent progress in the development of polysaccharide conjugates of docetaxel and paclitaxel.
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 6 (4), .
(doi:10.1002/wnan.1264).
Abstract
Taxanes are one of the most potent and broadest spectrum chemotherapeutics used clinically, but also induce significant side effects. Different strategies have been developed to produce a safer taxane formulation. Development of polysaccharide drug conjugates has increased in the recent years because of the demonstrated biocompatibility, biodegradability, safety, and low cost of the biopolymers. This review focuses on polysaccharide-taxane conjugates and provides an overview on various conjugation strategies and their effect on the efficacy. Detailed analyses on the designing factors of an effective polysaccharide-drug conjugate are provided with a discussion on the future direction of this field.
This record has no associated files available for download.
More information
Published date: 2014
Additional Information:
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
Identifiers
Local EPrints ID: 455301
URI: http://eprints.soton.ac.uk/id/eprint/455301
ISSN: 1939-5116
PURE UUID: e2644b81-4bb5-411e-9545-1578c12ff3fe
Catalogue record
Date deposited: 16 Mar 2022 18:04
Last modified: 17 Mar 2024 03:53
Export record
Altmetrics
Contributors
Author:
Aniruddha Roy
Author:
Mousumi Bhattacharyya
Author:
Mark J. Ernsting
Author:
Shyh Dar Li
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
