Truncated xpt gene present in invasive Streptococcus pneumoniae may have implications for MLST schemes
Truncated xpt gene present in invasive Streptococcus pneumoniae may have implications for MLST schemes
A serotype 1 disease-causing pneumococcus possessing a truncated xanthine phosphoribosyltransferase (xpt) housekeeping gene is described. The deletion is within the gene region used for multi-locus sequence typing (MLST) and may have occurred through genetic transformation or capsule switch between clones. The identification of this deletion in a clinical isolate therefore warrants highlighting due to potential errors that may ensue in isolate characterization and due to the fact that deletions may occur in other genes in this or other species characterized by MLST.
Bacterial Typing Techniques, Base Sequence, DNA, Bacterial/genetics, Genes, Bacterial, Humans, Molecular Sequence Data, Pentosyltransferases/genetics, Pneumococcal Infections/microbiology, Sequence Analysis, DNA, Sequence Deletion, Streptococcus pneumoniae/classification
909-912
Diggle, M A
d739c25b-e038-4a9a-850d-2e2fd6ff4a4f
Clarke, S C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
October 2005
Diggle, M A
d739c25b-e038-4a9a-850d-2e2fd6ff4a4f
Clarke, S C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Diggle, M A and Clarke, S C
(2005)
Truncated xpt gene present in invasive Streptococcus pneumoniae may have implications for MLST schemes.
Journal of Medical Microbiology, 54 (Pt 10), .
(doi:10.1099/jmm.0.46106-0).
Abstract
A serotype 1 disease-causing pneumococcus possessing a truncated xanthine phosphoribosyltransferase (xpt) housekeeping gene is described. The deletion is within the gene region used for multi-locus sequence typing (MLST) and may have occurred through genetic transformation or capsule switch between clones. The identification of this deletion in a clinical isolate therefore warrants highlighting due to potential errors that may ensue in isolate characterization and due to the fact that deletions may occur in other genes in this or other species characterized by MLST.
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Published date: October 2005
Keywords:
Bacterial Typing Techniques, Base Sequence, DNA, Bacterial/genetics, Genes, Bacterial, Humans, Molecular Sequence Data, Pentosyltransferases/genetics, Pneumococcal Infections/microbiology, Sequence Analysis, DNA, Sequence Deletion, Streptococcus pneumoniae/classification
Identifiers
Local EPrints ID: 455318
URI: http://eprints.soton.ac.uk/id/eprint/455318
ISSN: 0022-2615
PURE UUID: 4c4c40bf-a23b-41c8-b017-bcd1661fe28c
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Date deposited: 16 Mar 2022 18:07
Last modified: 17 Mar 2024 03:07
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Author:
M A Diggle
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