The University of Southampton
University of Southampton Institutional Repository

Virulence of enteropathogenic Escherichia coli, a global pathogen

Virulence of enteropathogenic Escherichia coli, a global pathogen
Virulence of enteropathogenic Escherichia coli, a global pathogen

Enteropathogenic Escherichia coli (EPEC) remains an important cause of diarrheal disease worldwide. Research into EPEC is intense and provides a good virulence model of other E. coli infections as well as other pathogenic bacteria. Although the virulence mechanisms are now better understood, they are extremely complex and much remains to be learnt. The pathogenesis of EPEC depends on the formation of an ultrastructural lesion in which the bacteria make intimate contact with the host apical enterocyte membrane. The formation of this lesion is a consequence of the ability of EPEC to adhere in a localized manner to the host cell, aided by bundle-forming pili. Tyrosine phosphorylation and signal transduction events occur within the host cell at the lesion site, leading to a disruption of the host cell mechanisms and, consequently, to diarrhea. These result from the action of highly regulated EPEC secreted proteins which are released via a type III secretion system, many genes of which are located within a pathogenicity island known as the locus of enterocyte effacement. Over the last few years, dramatic increases in our knowledge of EPEC virulence have taken place. This review therefore aims to provide a broad overview of and update to the virulence aspects of EPEC.

Bacterial Adhesion, Enterocytes/pathology, Escherichia coli/genetics, Fimbriae, Bacterial/physiology, Phosphorylation, Plasmids, Proteins/metabolism, Signal Transduction, Virulence
0893-8512
365-378
Clarke, S C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Haigh, R D
108c217e-fcf0-4550-9505-26e04ae63611
Freestone, P P E
207e08a2-e851-44c1-a12a-0d5a1490ea90
Williams, P H
f7e83b44-8a65-4ce9-b672-80b016dfc169
Clarke, S C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Haigh, R D
108c217e-fcf0-4550-9505-26e04ae63611
Freestone, P P E
207e08a2-e851-44c1-a12a-0d5a1490ea90
Williams, P H
f7e83b44-8a65-4ce9-b672-80b016dfc169

Clarke, S C, Haigh, R D, Freestone, P P E and Williams, P H (2003) Virulence of enteropathogenic Escherichia coli, a global pathogen. Clinical Microbiology Reviews, 16 (3), 365-378. (doi:10.1128/CMR.16.3.365-378.2003).

Record type: Review

Abstract

Enteropathogenic Escherichia coli (EPEC) remains an important cause of diarrheal disease worldwide. Research into EPEC is intense and provides a good virulence model of other E. coli infections as well as other pathogenic bacteria. Although the virulence mechanisms are now better understood, they are extremely complex and much remains to be learnt. The pathogenesis of EPEC depends on the formation of an ultrastructural lesion in which the bacteria make intimate contact with the host apical enterocyte membrane. The formation of this lesion is a consequence of the ability of EPEC to adhere in a localized manner to the host cell, aided by bundle-forming pili. Tyrosine phosphorylation and signal transduction events occur within the host cell at the lesion site, leading to a disruption of the host cell mechanisms and, consequently, to diarrhea. These result from the action of highly regulated EPEC secreted proteins which are released via a type III secretion system, many genes of which are located within a pathogenicity island known as the locus of enterocyte effacement. Over the last few years, dramatic increases in our knowledge of EPEC virulence have taken place. This review therefore aims to provide a broad overview of and update to the virulence aspects of EPEC.

This record has no associated files available for download.

More information

Published date: 1 July 2003
Additional Information: Copyright © 2003 American Society for Microbiology
Keywords: Bacterial Adhesion, Enterocytes/pathology, Escherichia coli/genetics, Fimbriae, Bacterial/physiology, Phosphorylation, Plasmids, Proteins/metabolism, Signal Transduction, Virulence

Identifiers

Local EPrints ID: 455399
URI: http://eprints.soton.ac.uk/id/eprint/455399
ISSN: 0893-8512
PURE UUID: b94f3248-e32f-4bbc-8cf8-8ea7a1f401ce
ORCID for S C Clarke: ORCID iD orcid.org/0000-0002-7009-1548

Catalogue record

Date deposited: 21 Mar 2022 17:34
Last modified: 23 Jul 2022 01:56

Export record

Altmetrics

Contributors

Author: S C Clarke ORCID iD
Author: R D Haigh
Author: P P E Freestone
Author: P H Williams

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×