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Vaccine preventable meningitis in Malaysia: epidemiology and management

Vaccine preventable meningitis in Malaysia: epidemiology and management
Vaccine preventable meningitis in Malaysia: epidemiology and management

Worldwide bacterial meningitis accounts for more than one million cases and 135,000 deaths annually. Profound, lasting neurological complications occur in 9-25% of cases. This review confirms the greatest risk from bacterial meningitis is in early life in Malaysia. Much of the disease burden can be avoided by immunization, particularly against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae. Despite inclusion of the Hib vaccine in the National Immunisation Programme and the licensure of pneumococcal vaccines, these two species are the main contributors to bacterial meningitis in Malaysia, with Neisseria meningitidis and Mycobacterium tuberculosis, causing a smaller proportion of disease. The high Hib prevalence may partly be due to dated, small-scale studies limiting the understanding of the current epidemiological situation. This highlights the need for larger, better quality surveillance from Malaysia to evaluate the success of Hib immunization and to help guide immunization policy for vaccines against S. pneumoniae and N. meningitidis.

Age Factors, Bacterial Capsules, Cost of Illness, Disease Management, Haemophilus Vaccines/therapeutic use, Haemophilus influenzae type b, Humans, Immunization Programs, Malaysia/epidemiology, Meningitis, Bacterial/classification, Pneumococcal Vaccines/therapeutic use, Streptococcus pneumoniae, Vaccination
1744-8336
705-714
McNeil, Hannah C
ca06cd91-3005-4321-858b-bab81da76ab4
Jefferies, Johanna M C
942356b7-2070-49ad-9376-cde03c5fe13d
Clarke, Stuart C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
McNeil, Hannah C
ca06cd91-3005-4321-858b-bab81da76ab4
Jefferies, Johanna M C
942356b7-2070-49ad-9376-cde03c5fe13d
Clarke, Stuart C
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17

McNeil, Hannah C, Jefferies, Johanna M C and Clarke, Stuart C (2015) Vaccine preventable meningitis in Malaysia: epidemiology and management. Expert Review of Anti-Infective Therapy, 13 (6), 705-714. (doi:10.1586/14787210.2015.1033401).

Record type: Review

Abstract

Worldwide bacterial meningitis accounts for more than one million cases and 135,000 deaths annually. Profound, lasting neurological complications occur in 9-25% of cases. This review confirms the greatest risk from bacterial meningitis is in early life in Malaysia. Much of the disease burden can be avoided by immunization, particularly against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae. Despite inclusion of the Hib vaccine in the National Immunisation Programme and the licensure of pneumococcal vaccines, these two species are the main contributors to bacterial meningitis in Malaysia, with Neisseria meningitidis and Mycobacterium tuberculosis, causing a smaller proportion of disease. The high Hib prevalence may partly be due to dated, small-scale studies limiting the understanding of the current epidemiological situation. This highlights the need for larger, better quality surveillance from Malaysia to evaluate the success of Hib immunization and to help guide immunization policy for vaccines against S. pneumoniae and N. meningitidis.

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More information

e-pub ahead of print date: 11 May 2015
Published date: 1 June 2015
Keywords: Age Factors, Bacterial Capsules, Cost of Illness, Disease Management, Haemophilus Vaccines/therapeutic use, Haemophilus influenzae type b, Humans, Immunization Programs, Malaysia/epidemiology, Meningitis, Bacterial/classification, Pneumococcal Vaccines/therapeutic use, Streptococcus pneumoniae, Vaccination

Identifiers

Local EPrints ID: 455550
URI: http://eprints.soton.ac.uk/id/eprint/455550
ISSN: 1744-8336
PURE UUID: 48db110c-c74e-419c-83f1-d338f0175f39
ORCID for Stuart C Clarke: ORCID iD orcid.org/0000-0002-7009-1548

Catalogue record

Date deposited: 25 Mar 2022 17:35
Last modified: 17 Mar 2024 03:07

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Contributors

Author: Hannah C McNeil
Author: Johanna M C Jefferies
Author: Stuart C Clarke ORCID iD

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