Hyperthermia-induced drug targeting
Hyperthermia-induced drug targeting
Introduction: Specific delivery of a drug to a target site is a major goal of drug delivery research. Using temperature-sensitive liposomes (TSLs) is one way to achieve this; the liposome acts as a protective carrier, allowing increased drug to flow through the bloodstream by minimizing clearance and non-specific uptake. On reaching microvessels within a heated tumor, the drug is released and quickly penetrates. A major advance in the field is ThermoDox® (Celsion), demonstrating significant improvements to the drug release rates and drug uptake in heated tumors (∼ 41°C). Most recently, magnetic resonance-guided focused ultrasound (MRgFUS) has been combined with TSL drug delivery to provide localized chemotherapy with simultaneous quantification of drug release within the tumor. Areas covered: In this article the field of hyperthermia-induced drug delivery is discussed, with an emphasis on the development of TSLs and their combination with hyperthermia (both mild and ablative) in cancer therapy. State-of-the-art image-guided heating technologies used with this combination strategy will also be presented, with examples of real-time monitoring of drug delivery and prediction of efficacy. Expert opinion: The specific delivery of drugs by combining hyperthermia with TSLs is showing great promise in the clinic and its potential will be even greater as the use of image-guided focused ultrasound becomes more widespread-a technique capable of penetrating deep within the body to heat a specific area with improved control. In conjunction with this, it is anticipated that multifunctional TSLs will be a major topic of study in this field.
HIFU, Mild hyperthermia, MRgFUS, Targeted drug delivery, Temperature-sensitive liposomes, Tumor ablation, Ultrasound
511-527
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
1 April 2013
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
Abstract
Introduction: Specific delivery of a drug to a target site is a major goal of drug delivery research. Using temperature-sensitive liposomes (TSLs) is one way to achieve this; the liposome acts as a protective carrier, allowing increased drug to flow through the bloodstream by minimizing clearance and non-specific uptake. On reaching microvessels within a heated tumor, the drug is released and quickly penetrates. A major advance in the field is ThermoDox® (Celsion), demonstrating significant improvements to the drug release rates and drug uptake in heated tumors (∼ 41°C). Most recently, magnetic resonance-guided focused ultrasound (MRgFUS) has been combined with TSL drug delivery to provide localized chemotherapy with simultaneous quantification of drug release within the tumor. Areas covered: In this article the field of hyperthermia-induced drug delivery is discussed, with an emphasis on the development of TSLs and their combination with hyperthermia (both mild and ablative) in cancer therapy. State-of-the-art image-guided heating technologies used with this combination strategy will also be presented, with examples of real-time monitoring of drug delivery and prediction of efficacy. Expert opinion: The specific delivery of drugs by combining hyperthermia with TSLs is showing great promise in the clinic and its potential will be even greater as the use of image-guided focused ultrasound becomes more widespread-a technique capable of penetrating deep within the body to heat a specific area with improved control. In conjunction with this, it is anticipated that multifunctional TSLs will be a major topic of study in this field.
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e-pub ahead of print date: 7 January 2013
Published date: 1 April 2013
Additional Information:
Funding Information:
We would like to acknowledge the following organizations for funding support to the Li lab: Ontario Institute for Cancer Research, MaRS Innovation, Ontario Centres of Excellence, Canadian Institutes of Health Research and Ontario Ministry of Economic Development and Innovation. S-D Li is supported by a Coalition to Cure Prostate Cancer Young Investigator Award. The authors state no conflict of interest and have received no payment in preparation of this manuscript.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
Keywords:
HIFU, Mild hyperthermia, MRgFUS, Targeted drug delivery, Temperature-sensitive liposomes, Tumor ablation, Ultrasound
Identifiers
Local EPrints ID: 455577
URI: http://eprints.soton.ac.uk/id/eprint/455577
ISSN: 1742-5247
PURE UUID: 6cfdc1de-2152-4b83-a3c1-5485dcb34bc3
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Date deposited: 28 Mar 2022 16:38
Last modified: 18 Mar 2024 03:49
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Author:
Shyh Dar Li
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