Thermosensitive liposomes in cancer therapy
Thermosensitive liposomes in cancer therapy
Thermosensitive liposomes have been a popular area of investigation for several years leading to a plentitude of scientific literature and several patents. The majority of formulations are still in the early stage of development and preclinical testing, although one formulation, ThermoDox®, is significantly more advanced. This formulation is now in clinical trials for a few different cancer indications. In this review, key patents and publications through the evolution of thermosensitive lipososomes are presented, including the use of polymers, lipids and other molecules to control the temperature sensitivity. ThermoDox® is discussed with an update on recent experiments and reports from the clinical trials. Finally, a summary of recent formulations designed to improve upon the ThermoDox® benchmark is presented, and the challenges and future directions for thermosensitive liposome technology are discussed.
Cancer therapeutic, Doxorubicin, Drug delivery, HIFU, Hyperthermia, Liposome, Magnetic resonance, MRgFUS, Nanoparticle, Thermosensitive, Ultrasound
148-158
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
1 July 2012
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Li, Shyh Dar
9a960896-36e7-4eb8-bd39-55580c60e36d
May, Jonathan P. and Li, Shyh Dar
(2012)
Thermosensitive liposomes in cancer therapy.
Recent Patents on Biomedical Engineering, 5 (2), .
(doi:10.2174/1874764711205020148).
Abstract
Thermosensitive liposomes have been a popular area of investigation for several years leading to a plentitude of scientific literature and several patents. The majority of formulations are still in the early stage of development and preclinical testing, although one formulation, ThermoDox®, is significantly more advanced. This formulation is now in clinical trials for a few different cancer indications. In this review, key patents and publications through the evolution of thermosensitive lipososomes are presented, including the use of polymers, lipids and other molecules to control the temperature sensitivity. ThermoDox® is discussed with an update on recent experiments and reports from the clinical trials. Finally, a summary of recent formulations designed to improve upon the ThermoDox® benchmark is presented, and the challenges and future directions for thermosensitive liposome technology are discussed.
This record has no associated files available for download.
More information
Published date: 1 July 2012
Keywords:
Cancer therapeutic, Doxorubicin, Drug delivery, HIFU, Hyperthermia, Liposome, Magnetic resonance, MRgFUS, Nanoparticle, Thermosensitive, Ultrasound
Identifiers
Local EPrints ID: 455578
URI: http://eprints.soton.ac.uk/id/eprint/455578
ISSN: 1874-7647
PURE UUID: 404a2cf6-bdd0-4637-a624-c602d722511d
Catalogue record
Date deposited: 28 Mar 2022 16:38
Last modified: 17 Mar 2024 03:53
Export record
Altmetrics
Contributors
Author:
Shyh Dar Li
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
