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Diastereoselectivity in the synthesis of syn-cis-3a-hydroxypyrrolo[2,3-b] indoline Nα′-methyl-dipeptide methyl esters

Diastereoselectivity in the synthesis of syn-cis-3a-hydroxypyrrolo[2,3-b] indoline Nα′-methyl-dipeptide methyl esters
Diastereoselectivity in the synthesis of syn-cis-3a-hydroxypyrrolo[2,3-b] indoline Nα′-methyl-dipeptide methyl esters

Described herein is a high yielding, diastereoselective synthesis of the syn-cis hydroxypyrroloindoline moiety by oxidation of the Nα-trityl- tryptophan-Nα-methyl-dipeptide methyl esters.

Diastereoselectivity, Hydroxypyrroloindole, Oxidation, Peptide natural products
0936-5214
3403-3406
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Patrick, Brian O.
44faf6ae-8ba6-4cb0-bcb7-0e7261948804
Perrin, David M.
12feb705-d3df-4f49-acf5-4283867ca47c
May, Jonathan P.
b54a262b-9f32-4435-8866-3b9c495294f3
Patrick, Brian O.
44faf6ae-8ba6-4cb0-bcb7-0e7261948804
Perrin, David M.
12feb705-d3df-4f49-acf5-4283867ca47c

May, Jonathan P., Patrick, Brian O. and Perrin, David M. (2006) Diastereoselectivity in the synthesis of syn-cis-3a-hydroxypyrrolo[2,3-b] indoline Nα′-methyl-dipeptide methyl esters. Synlett, (20), 3403-3406. (doi:10.1055/s-2006-958427).

Record type: Article

Abstract

Described herein is a high yielding, diastereoselective synthesis of the syn-cis hydroxypyrroloindoline moiety by oxidation of the Nα-trityl- tryptophan-Nα-methyl-dipeptide methyl esters.

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More information

Published date: 18 December 2006
Keywords: Diastereoselectivity, Hydroxypyrroloindole, Oxidation, Peptide natural products

Identifiers

Local EPrints ID: 455583
URI: http://eprints.soton.ac.uk/id/eprint/455583
ISSN: 0936-5214
PURE UUID: ec6d883f-25d1-4f00-a96f-2f4e416cc2fa
ORCID for Jonathan P. May: ORCID iD orcid.org/0000-0003-1651-130X

Catalogue record

Date deposited: 28 Mar 2022 16:38
Last modified: 17 Mar 2024 03:53

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Contributors

Author: Jonathan P. May ORCID iD
Author: Brian O. Patrick
Author: David M. Perrin

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