Extracellular matrix structure and stem cell mechanosensing
Extracellular matrix structure and stem cell mechanosensing
Extracellular matrix (ECM) is ubiquitous in multicellular life, and its structure is critical to the ability of organisms to survive, move, grow, and reproduce. Additionally, cells are able to probe and respond to the mechanical characteristics of ECM. This is important in almost all physiological processes, but particularly so in the behavior and regulation of stem cells within their niches. In this review, we outline the importance of mechanobiology in medicine, describe the research history of cellular mechanosensitivity, and explain why this is important in the biology of stem cells, focusing particularly on pluripotent stem cells. Finally, we put this research in the context of the structure and chemistry of materials that have been used to test theories about cellular mechanosensing.
Evans, N.D.
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Tusan, C.G.
729621e2-3f9f-4c0a-9800-99e0afeaf673
Evans, N.D.
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Tusan, C.G.
729621e2-3f9f-4c0a-9800-99e0afeaf673
Evans, N.D. and Tusan, C.G.
(2016)
Extracellular matrix structure and stem cell mechanosensing.
In,
Rawlinson, Simon C. F.
(ed.)
Mechanobiology: Exploitation for Medical Benefit.
Hoboken, New Jersey.
John Wiley & Sons Ltd..
(doi:10.1002/9781118966174.ch1).
Record type:
Book Section
Abstract
Extracellular matrix (ECM) is ubiquitous in multicellular life, and its structure is critical to the ability of organisms to survive, move, grow, and reproduce. Additionally, cells are able to probe and respond to the mechanical characteristics of ECM. This is important in almost all physiological processes, but particularly so in the behavior and regulation of stem cells within their niches. In this review, we outline the importance of mechanobiology in medicine, describe the research history of cellular mechanosensitivity, and explain why this is important in the biology of stem cells, focusing particularly on pluripotent stem cells. Finally, we put this research in the context of the structure and chemistry of materials that have been used to test theories about cellular mechanosensing.
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e-pub ahead of print date: 2016
Identifiers
Local EPrints ID: 455647
URI: http://eprints.soton.ac.uk/id/eprint/455647
PURE UUID: a95d29c4-dd66-48a4-badc-f5a8dd837ec6
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Date deposited: 30 Mar 2022 16:32
Last modified: 17 Mar 2024 03:22
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Author:
C.G. Tusan
Editor:
Simon C. F. Rawlinson
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