Diagnosis and management of bone fragility in diabetes: an emerging challenge
Diagnosis and management of bone fragility in diabetes: an emerging challenge
Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.
2585–2596
Ferrari, S.L.
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Abrahamsen, B.
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Napoli, N.
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Akesson, K.
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Chandran, M.
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Eastell, Richard
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El-Hajj Fuleihan, G.
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Josse, R.
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Kendler, David L.
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Kraenzlin, M.
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Suzuki, A.
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Pierroz, D.D.
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Schwartz, A.V.
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Leslie, W.D.
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Cooper, Cyrus
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on behalf of the Bone and Diabetes Working Group of IOF
Ferrari, S.L.
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Abrahamsen, B.
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Napoli, N.
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Akesson, K.
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Chandran, M.
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Eastell, Richard
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El-Hajj Fuleihan, G.
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Josse, R.
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Kendler, David L.
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Kraenzlin, M.
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Suzuki, A.
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Pierroz, D.D.
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Schwartz, A.V.
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Leslie, W.D.
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Cooper, Cyrus
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Ferrari, S.L., Abrahamsen, B., Napoli, N., Akesson, K., Chandran, M., Eastell, Richard, El-Hajj Fuleihan, G., Josse, R., Kendler, David L., Kraenzlin, M., Suzuki, A., Pierroz, D.D., Schwartz, A.V. and Leslie, W.D.
,
on behalf of the Bone and Diabetes Working Group of IOF
(2018)
Diagnosis and management of bone fragility in diabetes: an emerging challenge.
Osteoporosis International, .
(doi:10.1007/s00198-018-4650-2).
Abstract
Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.
Text
IOF_T2DM and Bone_OI_accepted
- Accepted Manuscript
Text
Ferrari2018_Article_DiagnosisAndManagementOfBoneFr
- Version of Record
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Accepted/In Press date: 19 July 2018
e-pub ahead of print date: 31 July 2018
Identifiers
Local EPrints ID: 455707
URI: http://eprints.soton.ac.uk/id/eprint/455707
ISSN: 0937-941X
PURE UUID: bd7d16bc-f201-4816-8a4e-2c084a96d867
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Date deposited: 31 Mar 2022 16:31
Last modified: 18 Mar 2024 02:47
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Contributors
Author:
S.L. Ferrari
Author:
B. Abrahamsen
Author:
N. Napoli
Author:
K. Akesson
Author:
M. Chandran
Author:
Richard Eastell
Author:
G. El-Hajj Fuleihan
Author:
R. Josse
Author:
David L. Kendler
Author:
M. Kraenzlin
Author:
A. Suzuki
Author:
D.D. Pierroz
Author:
A.V. Schwartz
Author:
W.D. Leslie
Corporate Author: on behalf of the Bone and Diabetes Working Group of IOF
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