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Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO

Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO
Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO
Background: Endocrine disrupting chemicals have harmful effects on reproductive, perinatal, and obstetric outcomes. 
Objective: To analyze the evidence on nutritional interventions to reduce the negative effects of endocrine disruptors on reproductive, perinatal, and obstetric outcomes. Search strategy: A search of MEDLINE (PubMed), Allied Health Literature (CINAHL), EMBASE, Web of Science, and the Cochrane Database was conducted from inception to May 2021. Selection criteria: Experimental studies on human populations. 
Data collection and analysis: Data were collected from eligible studies. Risk of bias assessment was completed using the Cochrane risk of bias tool and the ROBINS-I Tool. 
Results: Database searches yielded 15 362 articles. Removing 11 181 duplicates, 4181 articles underwent abstract screening, 26 articles were eligible for full manuscript review, and 16 met full inclusion criteria. Several Interventions were found to be effective in reducing exposure to endocrine disruptors: avoidance of plastic containers, bottles, and packaging; avoidance of canned food/beverages; consumption of fresh and organic food; avoidance of fast/processed foods; and supplementation with vitamin C, iodine, and folic acid. There were some interventional studies examining therapies to improve clinical outcomes related to endocrine disruptors. Conclusion: Dietary alterations can reduce exposure to endocrine disruptors, with limited data on interventions to improve endocrine-disruptor–related clinical outcomes. This review provides useful instruction to women, their families, healthcare providers, and regulatory bodies
endocrine disruptors, lifestyle interventions, nutritional interventions, perinatal morbidity, reproductive outcomes
0020-7292
489-501
Corbett, Gillian A
ce5f85d3-b38c-41c7-aae4-da8ed348b202
Lee, Sadhbh
775b1ff2-38f3-4481-829b-0fcdb8c92c47
Woodruff, Tracey J
652aff20-514e-47fb-9553-cc8b38552890
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Hod, Moshe
edce3a15-2721-489a-9feb-055a9e7e22b6
Charlesworth, Anne Marie
433e6b02-0b06-425f-a35b-d5134c9d76f5
Giudice, Linda
0b51bce5-c4b2-4f3d-8266-81f5a0558fc5
Conry, Jeanne
5131ccc8-9442-4ceb-98e7-652d6c6cee5e
McAuliffe, Fionnuala M
4338a5d7-8afc-4565-8edc-6c9928311c47
International Federation of Gynecology and Obstetrics (FIGO) Committee on Impact of Pregnancy on Long-term Health and the FIGO Committee on Climate Change and Toxic Environmental Exposures
Corbett, Gillian A
ce5f85d3-b38c-41c7-aae4-da8ed348b202
Lee, Sadhbh
775b1ff2-38f3-4481-829b-0fcdb8c92c47
Woodruff, Tracey J
652aff20-514e-47fb-9553-cc8b38552890
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Hod, Moshe
edce3a15-2721-489a-9feb-055a9e7e22b6
Charlesworth, Anne Marie
433e6b02-0b06-425f-a35b-d5134c9d76f5
Giudice, Linda
0b51bce5-c4b2-4f3d-8266-81f5a0558fc5
Conry, Jeanne
5131ccc8-9442-4ceb-98e7-652d6c6cee5e
McAuliffe, Fionnuala M
4338a5d7-8afc-4565-8edc-6c9928311c47

Corbett, Gillian A, Lee, Sadhbh, Woodruff, Tracey J, Hanson, Mark, Hod, Moshe and Charlesworth, Anne Marie , International Federation of Gynecology and Obstetrics (FIGO) Committee on Impact of Pregnancy on Long-term Health and the FIGO Committee on Climate Change and Toxic Environmental Exposures (2022) Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO. International Journal of Gynecology & Obstetrics, 157 (3), 489-501. (doi:10.1002/ijgo.14126).

Record type: Review

Abstract

Background: Endocrine disrupting chemicals have harmful effects on reproductive, perinatal, and obstetric outcomes. 
Objective: To analyze the evidence on nutritional interventions to reduce the negative effects of endocrine disruptors on reproductive, perinatal, and obstetric outcomes. Search strategy: A search of MEDLINE (PubMed), Allied Health Literature (CINAHL), EMBASE, Web of Science, and the Cochrane Database was conducted from inception to May 2021. Selection criteria: Experimental studies on human populations. 
Data collection and analysis: Data were collected from eligible studies. Risk of bias assessment was completed using the Cochrane risk of bias tool and the ROBINS-I Tool. 
Results: Database searches yielded 15 362 articles. Removing 11 181 duplicates, 4181 articles underwent abstract screening, 26 articles were eligible for full manuscript review, and 16 met full inclusion criteria. Several Interventions were found to be effective in reducing exposure to endocrine disruptors: avoidance of plastic containers, bottles, and packaging; avoidance of canned food/beverages; consumption of fresh and organic food; avoidance of fast/processed foods; and supplementation with vitamin C, iodine, and folic acid. There were some interventional studies examining therapies to improve clinical outcomes related to endocrine disruptors. Conclusion: Dietary alterations can reduce exposure to endocrine disruptors, with limited data on interventions to improve endocrine-disruptor–related clinical outcomes. This review provides useful instruction to women, their families, healthcare providers, and regulatory bodies

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Accepted/In Press date: 2 February 2022
e-pub ahead of print date: 4 February 2022
Published date: June 2022
Additional Information: Funding Information: TW declares funding sources from the JPB Foundation (US NIEHS 1P30ES030284 – 01A1). Open access funding provided by IReL. Publisher Copyright: © 2022 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.
Keywords: endocrine disruptors, lifestyle interventions, nutritional interventions, perinatal morbidity, reproductive outcomes

Identifiers

Local EPrints ID: 455763
URI: http://eprints.soton.ac.uk/id/eprint/455763
ISSN: 0020-7292
PURE UUID: 9d1db5c2-85b8-4e88-82db-ad9486064046
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 01 Apr 2022 22:30
Last modified: 13 Aug 2022 01:38

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Contributors

Author: Gillian A Corbett
Author: Sadhbh Lee
Author: Tracey J Woodruff
Author: Mark Hanson ORCID iD
Author: Moshe Hod
Author: Anne Marie Charlesworth
Author: Linda Giudice
Author: Jeanne Conry
Author: Fionnuala M McAuliffe
Corporate Author: International Federation of Gynecology and Obstetrics (FIGO) Committee on Impact of Pregnancy on Long-term Health and the FIGO Committee on Climate Change and Toxic Environmental Exposures

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