Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing
CD4+ and CD8+ T cell responses to endogenous retroviral envelope glycoprotein gp90 generate protective immunity to murine colon carcinoma CT26. A panel of I-Ad-restricted T cell hybridomas recognize gp90 synthesized by CT26 cells but not by other gp90-expressing tumors. Here we report that antigenicity resides in an incompletely folded form of gp90 that is unique to CT26. In contrast to more compact forms of gp90 that are present in other tumors, this open conformer is captured by recycling I-Ad on antigen-presenting cells and is processed intracellularly. Thus, gp90 acquires immunodominance via MHC-guided processing, and the generation of an MHC class II-restricted response can be controlled by the intracellular folding environment of antigen-expressing cells.
5983-5988
Mimura, Yusuke
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Mimura-Kimura, Yuka
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Doores, Katie
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Golgher, Denise
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Davis, Benjamin G.
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Dwek, Raymond A.
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Rudd, Pauline M.
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Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
3 April 2007
Mimura, Yusuke
f4cdf262-a937-4ba5-83d5-fac5a7d2f327
Mimura-Kimura, Yuka
4f779fd4-50bb-4171-b54a-e3bf4e6def3a
Doores, Katie
9e8d8a23-deef-46fb-8810-35886ac095dd
Golgher, Denise
9f810d0e-e5f6-48be-84a3-2631ea385816
Davis, Benjamin G.
2a8a594f-5d71-455a-bd99-d1366c1028cc
Dwek, Raymond A.
d8d9d5f8-f2c0-414e-b6b0-df77a33f0da4
Rudd, Pauline M.
7c9f5a3e-2e9f-4b2f-b16a-20dbcffe6a26
Elliott, Tim
16670fa8-c2f9-477a-91df-7c9e5b453e0e
Mimura, Yusuke, Mimura-Kimura, Yuka, Doores, Katie, Golgher, Denise, Davis, Benjamin G., Dwek, Raymond A., Rudd, Pauline M. and Elliott, Tim
(2007)
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.
Proceedings of the National Academy of Sciences of the United States of America, 104 (14), .
(doi:10.1073/pnas.0701307104).
Abstract
CD4+ and CD8+ T cell responses to endogenous retroviral envelope glycoprotein gp90 generate protective immunity to murine colon carcinoma CT26. A panel of I-Ad-restricted T cell hybridomas recognize gp90 synthesized by CT26 cells but not by other gp90-expressing tumors. Here we report that antigenicity resides in an incompletely folded form of gp90 that is unique to CT26. In contrast to more compact forms of gp90 that are present in other tumors, this open conformer is captured by recycling I-Ad on antigen-presenting cells and is processed intracellularly. Thus, gp90 acquires immunodominance via MHC-guided processing, and the generation of an MHC class II-restricted response can be controlled by the intracellular folding environment of antigen-expressing cells.
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Published date: 3 April 2007
Organisations:
Cancer Sciences
Identifiers
Local EPrints ID: 45577
URI: http://eprints.soton.ac.uk/id/eprint/45577
ISSN: 0027-8424
PURE UUID: f3383780-abcf-4d9f-be0f-dd76b12837c1
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Date deposited: 30 Mar 2007
Last modified: 16 Mar 2024 03:19
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Author:
Yusuke Mimura
Author:
Yuka Mimura-Kimura
Author:
Katie Doores
Author:
Denise Golgher
Author:
Benjamin G. Davis
Author:
Raymond A. Dwek
Author:
Pauline M. Rudd
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