The University of Southampton
University of Southampton Institutional Repository

Intermittent Pringle manoeuvre is not associated with adverse long-term prognosis after resection for colorectal liver metastases

Intermittent Pringle manoeuvre is not associated with adverse long-term prognosis after resection for colorectal liver metastases
Intermittent Pringle manoeuvre is not associated with adverse long-term prognosis after resection for colorectal liver metastases

BACKGROUND: Intermittent clamping of the porta hepatis, or the intermittent Pringle manoeuvre (IPM), is often used to control inflow during parenchymal liver transection. The aim of this study was to determine whether IPM is associated with an adverse long-term outcome after liver resection for colorectal liver metastasis (CRLM).

METHODS: All patients undergoing resection for CRLM in 1993-2006, for whom data on IPM were recorded, were included in the study. A total of 563 patients was available for analysis.

RESULTS: IPM was performed in 289 (51.3 per cent) of the patients. The duration of IPM ranged from 2 to 104 (median 22) min. There were no differences in clinicopathological features or postoperative morbidity between patients who had an IPM and those who did not. The median survival of patients undergoing IPM was 55.7 months compared with 48.9 months in those not having an IPM (P = 0.406). There was no difference in median disease-free survival between the two groups (22.1 versus 19.9 months respectively; P = 0.199).

CONCLUSION: IPM is not associated with an adverse long-term prognosis in patients undergoing liver resection for CRLM.

Aged, Blood Loss, Surgical/prevention & control, Colorectal Neoplasms, Constriction, Epidemiologic Methods, Female, Hepatectomy/adverse effects, Humans, Liver Neoplasms/mortality, Male, Prognosis, Treatment Outcome
0007-1323
985-989
Wong, K H V
12ac90f7-a601-4462-8703-f05c5ae909ca
Hamady, Z Z R
545a1c81-276e-4341-a420-aa10aa5d8ca8
Malik, H Z
07a4edfd-e6b7-4ef4-8120-6be46b04cb26
Prasad, R
ba7bf977-537b-4b45-9c7c-12024643c38f
Lodge, J P A
c97dd104-0cb2-4f05-a008-9b9af01e4820
Toogood, G J
f2183798-4d71-42fd-bcc9-483f191c066f
Wong, K H V
12ac90f7-a601-4462-8703-f05c5ae909ca
Hamady, Z Z R
545a1c81-276e-4341-a420-aa10aa5d8ca8
Malik, H Z
07a4edfd-e6b7-4ef4-8120-6be46b04cb26
Prasad, R
ba7bf977-537b-4b45-9c7c-12024643c38f
Lodge, J P A
c97dd104-0cb2-4f05-a008-9b9af01e4820
Toogood, G J
f2183798-4d71-42fd-bcc9-483f191c066f

Wong, K H V, Hamady, Z Z R, Malik, H Z, Prasad, R, Lodge, J P A and Toogood, G J (2008) Intermittent Pringle manoeuvre is not associated with adverse long-term prognosis after resection for colorectal liver metastases. British Journal of Surgery, 95 (8), 985-989. (doi:10.1002/bjs.6129).

Record type: Article

Abstract

BACKGROUND: Intermittent clamping of the porta hepatis, or the intermittent Pringle manoeuvre (IPM), is often used to control inflow during parenchymal liver transection. The aim of this study was to determine whether IPM is associated with an adverse long-term outcome after liver resection for colorectal liver metastasis (CRLM).

METHODS: All patients undergoing resection for CRLM in 1993-2006, for whom data on IPM were recorded, were included in the study. A total of 563 patients was available for analysis.

RESULTS: IPM was performed in 289 (51.3 per cent) of the patients. The duration of IPM ranged from 2 to 104 (median 22) min. There were no differences in clinicopathological features or postoperative morbidity between patients who had an IPM and those who did not. The median survival of patients undergoing IPM was 55.7 months compared with 48.9 months in those not having an IPM (P = 0.406). There was no difference in median disease-free survival between the two groups (22.1 versus 19.9 months respectively; P = 0.199).

CONCLUSION: IPM is not associated with an adverse long-term prognosis in patients undergoing liver resection for CRLM.

This record has no associated files available for download.

More information

Published date: 1 August 2008
Keywords: Aged, Blood Loss, Surgical/prevention & control, Colorectal Neoplasms, Constriction, Epidemiologic Methods, Female, Hepatectomy/adverse effects, Humans, Liver Neoplasms/mortality, Male, Prognosis, Treatment Outcome

Identifiers

Local EPrints ID: 455817
URI: http://eprints.soton.ac.uk/id/eprint/455817
ISSN: 0007-1323
PURE UUID: 2457f8f6-89b8-4b6f-91fc-02dd2bb92ff6
ORCID for Z Z R Hamady: ORCID iD orcid.org/0000-0002-4591-5226

Catalogue record

Date deposited: 05 Apr 2022 17:33
Last modified: 17 Mar 2024 04:12

Export record

Altmetrics

Contributors

Author: K H V Wong
Author: Z Z R Hamady ORCID iD
Author: H Z Malik
Author: R Prasad
Author: J P A Lodge
Author: G J Toogood

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×