The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity
The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity
Context: The kynurenine pathway generates metabolites integral to energy metabolism, neurotransmission, and immune function. Circulating kynurenine metabolites positively correlate with adiposity in children and adults, yet it is not known whether this relationship is present already at birth. Objective: In this prospective longitudinal study, we investigate the relationship between cord blood kynurenine metabolites and measures of adiposity from birth to 4.5 years. Methods: Liquid chromatography-tandem mass spectrometry was used to quantify cord blood kynurenine metabolites in 812 neonates from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study. Fat percentage was measured by air displacement plethysmography and abdominal adipose tissue compartment volumes; superficial (sSAT) and deep subcutaneous (dSAT) and internal adipose tissue were quantified by magnetic resonance imaging at early infancy in a smaller subset of neonates, and again at 4 to 4.5 years of age. Results: Cord blood kynurenine metabolites appeared to be higher in female newborns, higher in Indian newborns compared with Chinese newborns, and higher in infants born by cesarean section compared with vaginal delivery. Kynurenine, xanthurenic acid, and quinolinic acid were positively associated with birthweight, but not with subsequent weight during infancy and childhood. Quinolinic acid was positively associated with sSAT at birth. Kynurenic acid and quinolinic acid were positively associated with fat percentage at 4 years. Conclusion: Several cord blood kynurenine metabolite concentrations were positively associated with birthweight, with higher kynurenic acid and quinolinic acid correlating to higher percentage body fat in childhood, suggesting these cord blood metabolites as biomarkers of early childhood adiposity.
E2464-E2473
Tan, Karen Mei-Ling
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Tint, Mya-Thway
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Kothandaraman, Narasimhan
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Michael, Navin
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Sadananthan, Suresh Anand
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Velan, S. Sendhil
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Fortier, Marielle V.
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Yap, Fabian
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Tan, Kok Hian
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Gluckman, Peter D.
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Chong, Yap-Seng
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Chong, Mary F.F.
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Lee, Yung Seng
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Godfrey, Keith M.
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Eriksson, Johan G
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Cameron-Smith, David
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1 June 2022
Tan, Karen Mei-Ling
f8c09297-2230-4125-80ca-409dbbe92d8e
Tint, Mya-Thway
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Kothandaraman, Narasimhan
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Michael, Navin
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Sadananthan, Suresh Anand
41601e35-0034-44a4-b37f-87fc92adfe79
Velan, S. Sendhil
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Fortier, Marielle V.
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Yap, Fabian
40fd8e80-e79d-4572-b2ed-e72bc613b26d
Tan, Kok Hian
4714c94d-334a-42ad-b879-f3aa3a931def
Gluckman, Peter D.
2fadd34e-1a38-4105-8c1a-5c86ad9cb8d8
Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136
Chong, Mary F.F.
1e188259-b1ab-4448-9e65-5b6a0fd99502
Lee, Yung Seng
0e28a8d6-3085-4086-9fa1-ac0684783bcf
Godfrey, Keith M.
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Eriksson, Johan G
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Cameron-Smith, David
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Tan, Karen Mei-Ling, Tint, Mya-Thway, Kothandaraman, Narasimhan, Michael, Navin, Sadananthan, Suresh Anand, Velan, S. Sendhil, Fortier, Marielle V., Yap, Fabian, Tan, Kok Hian, Gluckman, Peter D., Chong, Yap-Seng, Chong, Mary F.F., Lee, Yung Seng, Godfrey, Keith M., Eriksson, Johan G and Cameron-Smith, David
(2022)
The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity.
Journal of Clinical Endocrinology & Metabolism, 107 (6), .
(doi:10.1210/clinem/dgac078).
Abstract
Context: The kynurenine pathway generates metabolites integral to energy metabolism, neurotransmission, and immune function. Circulating kynurenine metabolites positively correlate with adiposity in children and adults, yet it is not known whether this relationship is present already at birth. Objective: In this prospective longitudinal study, we investigate the relationship between cord blood kynurenine metabolites and measures of adiposity from birth to 4.5 years. Methods: Liquid chromatography-tandem mass spectrometry was used to quantify cord blood kynurenine metabolites in 812 neonates from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study. Fat percentage was measured by air displacement plethysmography and abdominal adipose tissue compartment volumes; superficial (sSAT) and deep subcutaneous (dSAT) and internal adipose tissue were quantified by magnetic resonance imaging at early infancy in a smaller subset of neonates, and again at 4 to 4.5 years of age. Results: Cord blood kynurenine metabolites appeared to be higher in female newborns, higher in Indian newborns compared with Chinese newborns, and higher in infants born by cesarean section compared with vaginal delivery. Kynurenine, xanthurenic acid, and quinolinic acid were positively associated with birthweight, but not with subsequent weight during infancy and childhood. Quinolinic acid was positively associated with sSAT at birth. Kynurenic acid and quinolinic acid were positively associated with fat percentage at 4 years. Conclusion: Several cord blood kynurenine metabolite concentrations were positively associated with birthweight, with higher kynurenic acid and quinolinic acid correlating to higher percentage body fat in childhood, suggesting these cord blood metabolites as biomarkers of early childhood adiposity.
Text
dgac078
- Accepted Manuscript
More information
Submitted date: 15 September 2021
Published date: 1 June 2022
Additional Information:
Funding Information:
This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore including Industry Alignment Fund Pre-Positioning Programme (IAF-PP), H17/01/a0/005.
Publisher Copyright:
© 2022 The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.
Identifiers
Local EPrints ID: 455950
URI: http://eprints.soton.ac.uk/id/eprint/455950
ISSN: 0021-972X
PURE UUID: d4d74e6c-6a9d-4b59-b48c-89ee5d013e01
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Date deposited: 11 Apr 2022 16:36
Last modified: 17 Mar 2024 07:11
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Contributors
Author:
Karen Mei-Ling Tan
Author:
Mya-Thway Tint
Author:
Narasimhan Kothandaraman
Author:
Navin Michael
Author:
Suresh Anand Sadananthan
Author:
S. Sendhil Velan
Author:
Marielle V. Fortier
Author:
Fabian Yap
Author:
Kok Hian Tan
Author:
Peter D. Gluckman
Author:
Yap-Seng Chong
Author:
Mary F.F. Chong
Author:
Yung Seng Lee
Author:
Johan G Eriksson
Author:
David Cameron-Smith
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