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Evaluation of stool short chain fatty acids profiles in the first year of life with childhood atopy-related outcomes

Evaluation of stool short chain fatty acids profiles in the first year of life with childhood atopy-related outcomes
Evaluation of stool short chain fatty acids profiles in the first year of life with childhood atopy-related outcomes
Introduction: Short chain fatty acids (SCFAs) are the main intestinal intermediate and end products of metabolism of dietary fibers/polyphenols by the gut microbiota. The aim of this study was to evaluate the biological implication of stool SCFA profiles determined in the first year of life on the clinical presentation of allergic outcomes in childhood. Methods: From the Growing Up in Singapore Toward healthy Outcomes (GUSTO) cohort, a sub-cohort of 75 participants was recruited. Scheduled questionnaire data was collected for cumulative prevalence of physician-diagnosed eczema, wheezing with the use of nebuliser, and allergen sensitization till the age of 8 years. Stool samples collected at week 3 and months 3, 6 and 12 were quantitated for 9 SCFAs using LC/MS/MS. SCFA data were grouped into lower (below the 25th) and higher (above the 75th percentiles) categories. Generalized Linear Mixed Models was employed to analyse longitudinal association between SCFAs and atopy-related outcomes. Results: Children with lower stool butyric acid levels (≤25th percentile) over the first 3 time points had higher odds ratio (OR) for wheezing (adjOR = 14.6), eczema (adjOR = 13.2), food sensitization (adjOR = 12.3) and combined outcomes of both wheezing and eczema (adjOR = 22.6) till age 8 years, compared to those with higher levels (≥75 percentile). Additionally, lower longitudinal levels of propionic acid (≤25th percentile) over 4 time points in first year of life was associated with recurrent wheezing (≥2 episodes) till 8 years (adjOR = 7.4) (adj p < 0.05). Conclusion: Our results suggest that relatively low levels of gut SCFAs in early life are associated with increased susceptibility to atopic-related outcomes in childhood.
2673-6101
Cheng, H.Y.
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Chan, James Chun Yip
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Yap, Gaik Chin
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Huang, Chiung-Hui
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Kioh, Dorinda Yan Qin
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Tham, Elizabeth Huiwen
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Loo, Evelyn X.L.
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Shek, Lynette P.
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Karmani, Neerja
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Goh, Anne Eng Neo
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van Bever, Hugo
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Teoh, Oon Hoe
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Chan, Yiong Huak
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Lay, Christopher
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Knol, Jan
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap-Seng
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Godfrey, Keith
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Chan, Eric Chun Yong
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Lee, Bee Wah
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Ta, Le Duc Huy
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Cheng, H.Y.
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Chan, James Chun Yip
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Yap, Gaik Chin
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Huang, Chiung-Hui
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Kioh, Dorinda Yan Qin
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Tham, Elizabeth Huiwen
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Loo, Evelyn X.L.
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Shek, Lynette P.
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Karmani, Neerja
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Goh, Anne Eng Neo
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van Bever, Hugo
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Teoh, Oon Hoe
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Chan, Yiong Huak
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Lay, Christopher
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Knol, Jan
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Yap, Fabian
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Tan, Kok Hian
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Chong, Yap-Seng
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Godfrey, Keith
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Chan, Eric Chun Yong
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Lee, Bee Wah
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Ta, Le Duc Huy
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Cheng, H.Y., Chan, James Chun Yip, Yap, Gaik Chin, Huang, Chiung-Hui, Kioh, Dorinda Yan Qin, Tham, Elizabeth Huiwen, Loo, Evelyn X.L., Shek, Lynette P., Karmani, Neerja, Goh, Anne Eng Neo, van Bever, Hugo, Teoh, Oon Hoe, Chan, Yiong Huak, Lay, Christopher, Knol, Jan, Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Godfrey, Keith, Chan, Eric Chun Yong, Lee, Bee Wah and Ta, Le Duc Huy (2022) Evaluation of stool short chain fatty acids profiles in the first year of life with childhood atopy-related outcomes. Frontiers in Allergy, 3. (doi:10.3389/falgy.2022.873168).

Record type: Article

Abstract

Introduction: Short chain fatty acids (SCFAs) are the main intestinal intermediate and end products of metabolism of dietary fibers/polyphenols by the gut microbiota. The aim of this study was to evaluate the biological implication of stool SCFA profiles determined in the first year of life on the clinical presentation of allergic outcomes in childhood. Methods: From the Growing Up in Singapore Toward healthy Outcomes (GUSTO) cohort, a sub-cohort of 75 participants was recruited. Scheduled questionnaire data was collected for cumulative prevalence of physician-diagnosed eczema, wheezing with the use of nebuliser, and allergen sensitization till the age of 8 years. Stool samples collected at week 3 and months 3, 6 and 12 were quantitated for 9 SCFAs using LC/MS/MS. SCFA data were grouped into lower (below the 25th) and higher (above the 75th percentiles) categories. Generalized Linear Mixed Models was employed to analyse longitudinal association between SCFAs and atopy-related outcomes. Results: Children with lower stool butyric acid levels (≤25th percentile) over the first 3 time points had higher odds ratio (OR) for wheezing (adjOR = 14.6), eczema (adjOR = 13.2), food sensitization (adjOR = 12.3) and combined outcomes of both wheezing and eczema (adjOR = 22.6) till age 8 years, compared to those with higher levels (≥75 percentile). Additionally, lower longitudinal levels of propionic acid (≤25th percentile) over 4 time points in first year of life was associated with recurrent wheezing (≥2 episodes) till 8 years (adjOR = 7.4) (adj p < 0.05). Conclusion: Our results suggest that relatively low levels of gut SCFAs in early life are associated with increased susceptibility to atopic-related outcomes in childhood.

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Accepted/In Press date: 22 March 2022
Published date: 6 April 2022

Identifiers

Local EPrints ID: 456075
URI: http://eprints.soton.ac.uk/id/eprint/456075
ISSN: 2673-6101
PURE UUID: ee242ae0-f42b-48a4-86da-150475e5f7a5
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

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Date deposited: 25 Apr 2022 16:56
Last modified: 24 Nov 2022 02:33

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Contributors

Author: H.Y. Cheng
Author: James Chun Yip Chan
Author: Gaik Chin Yap
Author: Chiung-Hui Huang
Author: Dorinda Yan Qin Kioh
Author: Elizabeth Huiwen Tham
Author: Evelyn X.L. Loo
Author: Lynette P. Shek
Author: Neerja Karmani
Author: Anne Eng Neo Goh
Author: Hugo van Bever
Author: Oon Hoe Teoh
Author: Yiong Huak Chan
Author: Christopher Lay
Author: Jan Knol
Author: Fabian Yap
Author: Kok Hian Tan
Author: Yap-Seng Chong
Author: Keith Godfrey ORCID iD
Author: Eric Chun Yong Chan
Author: Bee Wah Lee
Author: Le Duc Huy Ta

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