The University of Southampton
University of Southampton Institutional Repository

Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: a systematic review

Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: a systematic review
Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: a systematic review

Introduction: Respiratory tract infections (RTIs) are a major cause of morbidity and mortality in some high-risk groups including children and older adults. There is evidence that Chinese herbal medicine has an effect on RTIs. Reynoutria japonica Houtt (better known under its synonym Fallopia japonica (Houtt.) Ronse Decr.) (F. japonica), a commonly used Chinese herbal medicine, has a high content of resveratrol and glycosides. In traditional Chinese medicine theory, F. japonica has the effect of clearing heat in the body, improving blood and qi circulation, eliminating phlegm, and relieving cough, so it may have an effect on RTIs. Methods: This systematic review was registered under PROSPERO CRD42020188604. Databases were searched for randomized controlled trials of F. japonica as a single herb, or as a component of a complex herbal formula for RTIs. Quality of methodology was assessed by two reviewers independently using the Cochrane Risk of Bias Tool. The primary outcome was symptom improvement rate. The secondary outcome measures were fever clearance time, Murray lung injury score and incidence of adverse effects. The extracted data were pooled and meta-analysed by RevMan 5.3 software. Results: Eight RCTs with 1,123 participants with acute RTIs were included in this systematic review, and all the RCTs used F. japonica as part of a herbal mixture. Only one included trial used F. japonica in a herbal mixture without antibiotics in the treatment group. The findings showed that herbal remedies that included F. japonica could increase the symptom improvement rate (risk ratio 1.14, 95% confidence intervals [1.09, 1.20], I 2 = 0%, p < 0.00001, n = 7 trials, 1,013 participants), shorten fever duration, reduce Murray lung injury score and did not increase adverse events (RR 0.33, 95% CI [0.11, 1.00], I 2 = 0%, p = 0.05, n = 5 trials, 676 participants). Conclusion: There is limited but some evidence that F. japonica as part of a herbal mixture may be an effective and safe intervention for acute RTIs in clinical practice. In future studies it would be preferable to evaluate the effectiveness and safety of using F. japonica without antibiotics for acute RTIs.

herbal remedy, meta-analysis, randomized controlled trials, respiratory tract infections (RTIs), reynoutria japonica
1663-9812
Wang, Zhi-Jie
4ea33545-987a-41d7-a2c0-96f72655bd70
Trill, Jeanne
c952c8c6-6168-4dda-9185-7b92ff232fb5
Tan, Lin-Lin
61c05cbb-862a-4370-96dd-c83a4967b742
Chang, Wen-Jing
66a573b3-0e8c-4f6d-aa90-49e592303986
Zhang, Yu
a851ce00-2181-4b85-bb62-50fcbee83a95
Willcox, Merlin
dad5b622-9ac2-417d-9b2e-aad41b64ffea
Xia, Ru-Yu
93e6664d-40f0-43e8-b156-e0d037404694
Jiang, Yue
b57d7b5b-95f4-4eed-839a-2cd53280b656
Moore, Michael
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Liu, Jian-Ping
4c1de9c3-e9c2-4d4e-a0a4-dad123a39c76
Hu, Xiao-Yang
65904b24-3775-4b14-9532-eb703a056655
Wang, Zhi-Jie
4ea33545-987a-41d7-a2c0-96f72655bd70
Trill, Jeanne
c952c8c6-6168-4dda-9185-7b92ff232fb5
Tan, Lin-Lin
61c05cbb-862a-4370-96dd-c83a4967b742
Chang, Wen-Jing
66a573b3-0e8c-4f6d-aa90-49e592303986
Zhang, Yu
a851ce00-2181-4b85-bb62-50fcbee83a95
Willcox, Merlin
dad5b622-9ac2-417d-9b2e-aad41b64ffea
Xia, Ru-Yu
93e6664d-40f0-43e8-b156-e0d037404694
Jiang, Yue
b57d7b5b-95f4-4eed-839a-2cd53280b656
Moore, Michael
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Liu, Jian-Ping
4c1de9c3-e9c2-4d4e-a0a4-dad123a39c76
Hu, Xiao-Yang
65904b24-3775-4b14-9532-eb703a056655

Wang, Zhi-Jie, Trill, Jeanne, Tan, Lin-Lin, Chang, Wen-Jing, Zhang, Yu, Willcox, Merlin, Xia, Ru-Yu, Jiang, Yue, Moore, Michael, Liu, Jian-Ping and Hu, Xiao-Yang (2022) Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: a systematic review. Frontiers in Pharmacology, 13, [787032]. (doi:10.3389/fphar.2022.787032).

Record type: Review

Abstract

Introduction: Respiratory tract infections (RTIs) are a major cause of morbidity and mortality in some high-risk groups including children and older adults. There is evidence that Chinese herbal medicine has an effect on RTIs. Reynoutria japonica Houtt (better known under its synonym Fallopia japonica (Houtt.) Ronse Decr.) (F. japonica), a commonly used Chinese herbal medicine, has a high content of resveratrol and glycosides. In traditional Chinese medicine theory, F. japonica has the effect of clearing heat in the body, improving blood and qi circulation, eliminating phlegm, and relieving cough, so it may have an effect on RTIs. Methods: This systematic review was registered under PROSPERO CRD42020188604. Databases were searched for randomized controlled trials of F. japonica as a single herb, or as a component of a complex herbal formula for RTIs. Quality of methodology was assessed by two reviewers independently using the Cochrane Risk of Bias Tool. The primary outcome was symptom improvement rate. The secondary outcome measures were fever clearance time, Murray lung injury score and incidence of adverse effects. The extracted data were pooled and meta-analysed by RevMan 5.3 software. Results: Eight RCTs with 1,123 participants with acute RTIs were included in this systematic review, and all the RCTs used F. japonica as part of a herbal mixture. Only one included trial used F. japonica in a herbal mixture without antibiotics in the treatment group. The findings showed that herbal remedies that included F. japonica could increase the symptom improvement rate (risk ratio 1.14, 95% confidence intervals [1.09, 1.20], I 2 = 0%, p < 0.00001, n = 7 trials, 1,013 participants), shorten fever duration, reduce Murray lung injury score and did not increase adverse events (RR 0.33, 95% CI [0.11, 1.00], I 2 = 0%, p = 0.05, n = 5 trials, 676 participants). Conclusion: There is limited but some evidence that F. japonica as part of a herbal mixture may be an effective and safe intervention for acute RTIs in clinical practice. In future studies it would be preferable to evaluate the effectiveness and safety of using F. japonica without antibiotics for acute RTIs.

Text
fphar-13-787032 - Version of Record
Available under License Creative Commons Attribution.
Download (2MB)

More information

Accepted/In Press date: 31 January 2022
Published date: 24 February 2022
Keywords: herbal remedy, meta-analysis, randomized controlled trials, respiratory tract infections (RTIs), reynoutria japonica

Identifiers

Local EPrints ID: 456115
URI: http://eprints.soton.ac.uk/id/eprint/456115
ISSN: 1663-9812
PURE UUID: cfed6513-a3ad-4883-94af-9432341b1a26
ORCID for Merlin Willcox: ORCID iD orcid.org/0000-0002-5227-3444
ORCID for Michael Moore: ORCID iD orcid.org/0000-0002-5127-4509
ORCID for Xiao-Yang Hu: ORCID iD orcid.org/0000-0002-3143-7999

Catalogue record

Date deposited: 26 Apr 2022 14:53
Last modified: 28 Apr 2022 02:18

Export record

Altmetrics

Contributors

Author: Zhi-Jie Wang
Author: Jeanne Trill
Author: Lin-Lin Tan
Author: Wen-Jing Chang
Author: Yu Zhang
Author: Merlin Willcox ORCID iD
Author: Ru-Yu Xia
Author: Yue Jiang
Author: Michael Moore ORCID iD
Author: Jian-Ping Liu
Author: Xiao-Yang Hu ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×