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Hyperpolarization read-out through rapidly rotating fields in the zero- and low-field regime

Hyperpolarization read-out through rapidly rotating fields in the zero- and low-field regime
Hyperpolarization read-out through rapidly rotating fields in the zero- and low-field regime
An integral part of para-hydrogen induced polarization (PHIP) methods is the conversion of nuclear singlet order into observable magnetization. In this study polarization transfer to a heteronucleus is achieved through a selective rotation of the proton singlet–triplet states driven by a combination of a rotating magnetic field and a weak bias field. Surprisingly we find that efficient polarization transfer driven by a STORM (Singlet–Triplet Oscillations through Rotating Magnetic fields) pulse in the presence of sub-μT bias fields requires rotation frequencies on the order of several kHz. The rotation frequencies therefore greatly exceed any of the internal frequencies of typical zero- to ultralow field experiments. We further show that the rotational direction of the rotating field is not arbitrary and greatly influences the final transfer efficiency. Some of these aspects are demonstrated experimentally by considering hyperpolarized (1-13C)fumarate. In contrast to most of the existing methods, the STORM procedure therefore represents a promising candidate for quadrupolar decoupled polarization transfer in PHIP experiments.
1463-9076
8321-8328
Dagys, Laurynas
0de61597-b152-4bee-a934-123a9d2de883
Bengs, Christian
6d086f95-d3e8-4adc-86a5-6b255aee4dd1
Dagys, Laurynas
0de61597-b152-4bee-a934-123a9d2de883
Bengs, Christian
6d086f95-d3e8-4adc-86a5-6b255aee4dd1

Dagys, Laurynas and Bengs, Christian (2022) Hyperpolarization read-out through rapidly rotating fields in the zero- and low-field regime. Physical Chemistry Chemical Physics, 24 (14), 8321-8328. (doi:10.1039/d1cp04653e).

Record type: Article

Abstract

An integral part of para-hydrogen induced polarization (PHIP) methods is the conversion of nuclear singlet order into observable magnetization. In this study polarization transfer to a heteronucleus is achieved through a selective rotation of the proton singlet–triplet states driven by a combination of a rotating magnetic field and a weak bias field. Surprisingly we find that efficient polarization transfer driven by a STORM (Singlet–Triplet Oscillations through Rotating Magnetic fields) pulse in the presence of sub-μT bias fields requires rotation frequencies on the order of several kHz. The rotation frequencies therefore greatly exceed any of the internal frequencies of typical zero- to ultralow field experiments. We further show that the rotational direction of the rotating field is not arbitrary and greatly influences the final transfer efficiency. Some of these aspects are demonstrated experimentally by considering hyperpolarized (1-13C)fumarate. In contrast to most of the existing methods, the STORM procedure therefore represents a promising candidate for quadrupolar decoupled polarization transfer in PHIP experiments.

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Accepted/In Press date: 21 February 2022
Published date: 23 March 2022
Additional Information: Funding Information: We acknowledge funding received by the Marie Skłodowska-Curie program of the European Union (grant number 766402), the European Research Council (grant 786707-FunMagResBeacons), and EPSRC-UK (grants EP/P009980/1, EP/P030491/1, EP/V055593/1). We thank Malcolm H. Levitt for valuable input and support during preparation of the manuscript. Publisher Copyright: © 2022 The Royal Society of Chemistry

Identifiers

Local EPrints ID: 456269
URI: http://eprints.soton.ac.uk/id/eprint/456269
ISSN: 1463-9076
PURE UUID: 7bb3169d-f67c-4287-be1a-af2c70d30c60

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Date deposited: 27 Apr 2022 00:57
Last modified: 24 Jan 2023 17:35

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Author: Laurynas Dagys
Author: Christian Bengs

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