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Systems redox biology in health and disease

Systems redox biology in health and disease
Systems redox biology in health and disease
Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges. Understanding how the multi-layered biological stress responses become integrated across and between different levels of organization within an organism can provide a different perspective on the nature and inter-relationship of complex systems in health and disease. We here compare two concepts which have been very influential in stress research: Selye’s ‘General Adaptation Syn-drome’ and Sies’s ‘Oxidative Stress’ paradigm. We show that both can be embraced within a more general frame-work of ‘change and response’. The ‘Reactive Species Interactome’ allows each of these to be considered as dis-tinct but complementary aspects of the same system, representative of roles at different levels of organization within a functional hierarchy. The versatile chemistry of sulfur - exemplified by hydrogen sulfide, glutathione and proteinous cysteine thiols - enriched by its interactions with reactive oxygen, nitrogen and sulfur species, would seem to sit at the heart of the ‘Redox Code’ and underpin the ability of complex organisms to cope with stress.
Integrated physiology, hydrogen sulfide, nutrition, oxidative stress, redox signaling, systems medicine
1611-2156
623-646
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Cortese-Krott, Miriam M.
7dc9b44c-847c-4196-8866-a3cc0c1dc357
Santolini, Jerome
2e9403c4-40a3-4e49-bd50-916d01de14da
Wootton, Stephen
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan
c9a12d7c-b4d6-4c92-820e-890a688379ef
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Cortese-Krott, Miriam M.
7dc9b44c-847c-4196-8866-a3cc0c1dc357
Santolini, Jerome
2e9403c4-40a3-4e49-bd50-916d01de14da
Wootton, Stephen
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Jackson, Alan
c9a12d7c-b4d6-4c92-820e-890a688379ef

Feelisch, Martin, Cortese-Krott, Miriam M., Santolini, Jerome, Wootton, Stephen and Jackson, Alan (2022) Systems redox biology in health and disease. EXCLI, 21, 623-646. (doi:10.17179/excli2022-4793).

Record type: Review

Abstract

Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges. Understanding how the multi-layered biological stress responses become integrated across and between different levels of organization within an organism can provide a different perspective on the nature and inter-relationship of complex systems in health and disease. We here compare two concepts which have been very influential in stress research: Selye’s ‘General Adaptation Syn-drome’ and Sies’s ‘Oxidative Stress’ paradigm. We show that both can be embraced within a more general frame-work of ‘change and response’. The ‘Reactive Species Interactome’ allows each of these to be considered as dis-tinct but complementary aspects of the same system, representative of roles at different levels of organization within a functional hierarchy. The versatile chemistry of sulfur - exemplified by hydrogen sulfide, glutathione and proteinous cysteine thiols - enriched by its interactions with reactive oxygen, nitrogen and sulfur species, would seem to sit at the heart of the ‘Redox Code’ and underpin the ability of complex organisms to cope with stress.

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4793-Article Text (primary submission content)-42018-1-10-20220322 - Version of Record
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Accepted/In Press date: 16 March 2022
Published date: 21 March 2022
Additional Information: Publisher Copyright: © 2022, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved. Copyright: Copyright 2022 Elsevier B.V., All rights reserved.
Keywords: Integrated physiology, hydrogen sulfide, nutrition, oxidative stress, redox signaling, systems medicine

Identifiers

Local EPrints ID: 456384
URI: http://eprints.soton.ac.uk/id/eprint/456384
ISSN: 1611-2156
PURE UUID: 43d1cef4-cec6-4570-8263-528c379e30ba
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 27 Apr 2022 15:30
Last modified: 31 May 2022 01:43

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Contributors

Author: Martin Feelisch ORCID iD
Author: Miriam M. Cortese-Krott
Author: Jerome Santolini
Author: Stephen Wootton
Author: Alan Jackson

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