Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection
The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data from a randomized efficacy trial of the ChAdOx1 nCoV-19 (AZD1222) vaccine in the United Kingdom was analyzed to determine the antibody levels associated with protection against SARS-CoV-2. Binding and neutralizing antibodies at 28 days after the second dose were measured in infected and noninfected vaccine recipients. Higher levels of all immune markers were correlated with a reduced risk of symptomatic infection. A vaccine efficacy of 80% against symptomatic infection with majority Alpha (B.1.1.7) variant of SARS-CoV-2 was achieved with 264 (95% CI: 108, 806) binding antibody units (BAU)/ml: and 506 (95% CI: 135, not computed (beyond data range) (NC)) BAU/ml for anti-spike and anti-RBD antibodies, and 26 (95% CI: NC, NC) international unit (IU)/ml and 247 (95% CI: 101, NC) normalized neutralization titers (NF50) for pseudovirus and live-virus neutralization, respectively. Immune markers were not correlated with asymptomatic infections at the 5% significance level. These data can be used to bridge to new populations using validated assays, and allow extrapolation of efficacy estimates to new COVID-19 vaccines.
2032-2040
Feng, Shuo
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Phillips, Daniel J.
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White, Thomas
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Sayal, Homesh
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Aley, Parvinder K.
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Bibi, Sagida
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Dold, Christina
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Fuskova, Michelle
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Gilbert, Sarah C.
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Hirsch, Ian
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Humphries, Holly E.
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Jepson, Brett
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Kelly, Elizabeth J.
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Plested, Emma
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Shoemaker, Kathryn
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Thomas, Kelly M.
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Villafana, Tonya L.
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Lambe, Teresa
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Pollard, Andrew J.
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Voysey, Merryn
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Adlou, Syed
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Allen, Lauren
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Angus, Brian
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Anslow, Rachel
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Asselin, Marie Claude
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Baker, Natalie
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Baker, Philip
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Brown, Phillip
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Brunt, Emily
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Buttigieg, Karen R.
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Camara, Susana
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Charlton, Sue
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Chiplin, Emily
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Cicconi, Paola
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Collins, Andrea M.
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Coombes, Naomi S.
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Clemens, Sue Ann Costa
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Davison, Melanie
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Demissie, Tesfaye
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Dinesh, Tanya
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Douglas, Alexander D.
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Smith, Andrew
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Turner, David P.J.
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Williams, Christopher J.
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the Oxford COVID Vaccine Trial Group
29 September 2021
Feng, Shuo
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Phillips, Daniel J.
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White, Thomas
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Sayal, Homesh
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Aley, Parvinder K.
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Bibi, Sagida
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Dold, Christina
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Fuskova, Michelle
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Gilbert, Sarah C.
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Hirsch, Ian
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Humphries, Holly E.
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Jepson, Brett
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Kelly, Elizabeth J.
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Plested, Emma
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Shoemaker, Kathryn
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Thomas, Kelly M.
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Vekemans, Johan
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Villafana, Tonya L.
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Lambe, Teresa
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Pollard, Andrew J.
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Voysey, Merryn
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Adlou, Syed
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Allen, Lauren
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Angus, Brian
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Anslow, Rachel
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Asselin, Marie Claude
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Baker, Natalie
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Baker, Philip
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Barlow, Thomas
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Beveridge, Amy
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Bewley, Kevin R.
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Brown, Phillip
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Brunt, Emily
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Buttigieg, Karen R.
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Camara, Susana
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Charlton, Sue
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Chiplin, Emily
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Cicconi, Paola
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Clutterbuck, Elizabeth A.
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Collins, Andrea M.
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Coombes, Naomi S.
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Davison, Melanie
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Demissie, Tesfaye
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Dinesh, Tanya
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Douglas, Alexander D.
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Green, Christopher A.
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Smith, Andrew
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Turner, David P.J.
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Williams, Christopher J.
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